EC: 3.6.1.9

nucleotide diphosphatase (dinucleotide nucleotidohydrolase)

enzyme lambda metabolic reaction experiment
uniprot:Q9NV35 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype NUDT15]

dGTP + H2O -> dGMP + Diphosphate
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 0.1 M Tris-acetate, 40 mM NaCl, 10 mM MgAc, 1 mM dithiothreitol, 0.005% Tween-20
PH: 7.5
Temperature: 22
uniprot:Q9NV35 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype NUDT15]

H2O + 8_oxo_dGTP -> 8_oxo_dGMP + Diphosphate
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 0.1 M Tris-acetate, 40 mM NaCl, 10 mM MgAc, 1 mM dithiothreitol, 0.005% Tween-20
PH: 7.5
Temperature: 22
uniprot:P36639 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype MTH1]

dGTP + H2O -> dGMP + Diphosphate
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 0.1 M Tris-acetate, 40 mM NaCl, 10 mM MgAc, 1 mM dithiothreitol, 0.005% Tween-20
PH: 7.5
Temperature: 22
uniprot:P36639 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype MTH1]

H2O + 8_oxo_dGTP -> Diphosphate + 8_oxo_dGMP
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 0.1 M Tris-acetate, 40 mM NaCl, 10 mM MgAc, 1 mM dithiothreitol, 0.005% Tween-20
PH: 7.5
Temperature: 22
uniprot:Q8BG93 [Mg2+]

H2O + dGTP -> Diphosphate + dGMP
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml bovine serum albumin, 40 mM NaCl, 5 mM DTT, 2 % glycerol
PH: 8
Temperature: 30
uniprot:Q8BG93 [Mg2+]

H2O + 8_oxo_dGTP -> Diphosphate + 8_oxo_dGMP
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml bovine serum albumin, 40 mM NaCl, 5 mM DTT, 2 % glycerol
PH: 8
Temperature: 30
uniprot:Q9BY32 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype]

XTP + H2O -> Diphosphate + XMP
(( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 50 mM MgCl2, 1 mM Dithiothreitol, 1.25 U/ml Inorganic Pyrophosphatase
PH: 8.5
Temperature: 37
uniprot:Q9BY32 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype]

ITP + H2O -> IMP + Diphosphate
(( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 50 mM MgCl2, 1 mM Dithiothreitol, 1.25 U/ml Inorganic Pyrophosphatase
PH: 8.5
Temperature: 37
uniprot:Q9BY32 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype]

dITP + H2O -> dIMP + Diphosphate
(( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 50 mM MgCl2, 1 mM Dithiothreitol, 1.25 U/ml Inorganic Pyrophosphatase
PH: 8.5
Temperature: 37
uniprot:Q924C3 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype isoenzyme Enpp1]

H2O + UDPglucose -> UMP + D_Glucose_1_phosphate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl, 10 mM MgCl2, 8 µg/ml membrane protein
PH: 8.9
Temperature: 25
uniprot:Q924C3 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype isoenzyme Enpp1]

UTP + H2O -> Diphosphate + UMP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl, 10 mM MgCl2, 8 µg/ml membrane protein
PH: 8.9
Temperature: 25
uniprot:Q924C3 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype isoenzyme Enpp1]

p_Nitrophenylthymidine_phosphate + H2O -> p_Nitrophenol + dTMP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl, 10 mM MgCl2, 0.2 µg/ml membrane protein
PH: 8.9
Temperature: 25
- [nucleoside-triphosphate diphosphatase(Enzyme) wildtype]

H2O + p_Nitrophenylthymidine_phosphate -> dTMP + p_Nitrophenol
(( (V * S) ) / (Km + S)) buffer: 100 mM glycine-NaOH, 5 mM MgCl2, 100 µM ZnCl2
PH: 9.6
Temperature: 20
- [nucleoside-triphosphate diphosphatase(Enzyme) wildtype]

H2O + p_Nitrophenylthymidine_phosphate -> p_Nitrophenol + dTMP
(( (V * S) ) / (Km + S)) buffer: 100 mM glycine-NaOH, 5 mM MgCl2, 100 µM ZnCl2
PH: 9.6
Temperature: 20
uniprot:P97675 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype]

H2O + NAD+ -> AMP + Nicotinamide_nucleotide
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M triethanolamine, 0.1 mM ATP, 0.2 mM NADH, 10 mM MgCl2, 1 mM phosphoenol pyruvate, 0.1 M potassium chloride, 3.5 U/ml myokinase, 1.5 U/ml pyruvate kinase, 3.5 U/ml lactate dehydrogenase
PH: 7.6
Temperature: 37
uniprot:P97675 [ADPribose]

NADH + H2O -> AMP + Reduced_nicotinamide_nucleotide
(( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 0.1 M Tris, 10 mM MgCl2
PH: 9
Temperature: 37
uniprot:P97675 [UDPglucose]

NADH + H2O -> Reduced_nicotinamide_nucleotide + AMP
(( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 0.1 M Tris, 10 mM MgCl2
PH: 9
Temperature: 37
uniprot:P97675 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype]

UDPglucose + H2O -> UMP + D_Glucose_1_phosphate
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M triethanolamine, 0.1 mM ATP, 0.2 mM NADH, 10 mM MgCl2, 1 mM phosphoenol pyruvate, 0.1 M potassium chloride, 3.5 U/ml myokinase, 1.5 U/ml pyruvate kinase, 3.5 U/ml lactate dehydrogenase
PH: 7.6
Temperature: 37
uniprot:P97675 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype]

NADH + H2O -> AMP + Reduced_nicotinamide_nucleotide
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Tris, 10 mM MgCl2
PH: 9
Temperature: 37
uniprot:P97675 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype]

ADPribose + H2O -> AMP + D_Ribose_1_phosphate
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M triethanolamine, 0.1 mM ATP, 0.2 mM NADH, 10 mM MgCl2, 1 mM phosphoenol pyruvate, 0.1 M potassium chloride, 3.5 U/ml myokinase, 1.5 U/ml pyruvate kinase, 3.5 U/ml lactate dehydrogenase
PH: 7.6
Temperature: 37
uniprot:Q924C3 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype isoenzyme Enpp1]

H2O + ATP -> AMP + Diphosphate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl, 10 mM MgCl2, 8 µg/ml membrane protein
PH: 8.9
Temperature: 25
uniprot:Q924C3 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype isoenzyme Enpp1]

H2O + ADP -> AMP + Phosphate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl, 10 mM MgCl2, 8 µg/ml membrane protein
PH: 8.9
Temperature: 25
uniprot:Q924C3 [UMP]

p_Nitrophenylthymidine_phosphate + H2O -> p_Nitrophenol + dTMP
(( (Vmax * S) ) / (( (Km * (1 + (I / Ki))) ) + S)) buffer: 100 mM Tris-HCl, 10 mM MgCl2, 0.2 µg/ml membrane protein
PH: 8.9
Temperature: 25
uniprot:Q924C3 [alpha,beta-Methylene ATP]

H2O + p_Nitrophenylthymidine_phosphate -> p_Nitrophenol + dTMP
(( (Vmax * S) ) / (( (Km * (1 + (I / Ki))) ) + S)) buffer: 100 mM Tris-HCl, 10 mM MgCl2, 0.2 µg/ml membrane protein
PH: 8.9
Temperature: 25
uniprot:Q924C3 [UDPglucose]

p_Nitrophenylthymidine_phosphate + H2O -> dTMP + p_Nitrophenol
(( (Vmax * S) ) / (( (Km * (1 + (I / Ki))) ) + S)) buffer: 100 mM Tris-HCl, 10 mM MgCl2, 0.2 µg/ml membrane protein
PH: 8.9
Temperature: 25
uniprot:Q924C3 [Adenosine 5'-phosphoramidate]

H2O + p_Nitrophenylthymidine_phosphate -> dTMP + p_Nitrophenol
(( (Vmax * S) ) / (( (Km * (1 + (I / Ki))) ) + S)) buffer: 100 mM Tris-HCl, 10 mM MgCl2, 0.2 µg/ml membrane protein
PH: 8.9
Temperature: 25
uniprot:Q924C3 [nucleoside-triphosphate diphosphatase(Enzyme) wildtype isoenzyme Enpp1]

H2O + UDP -> Phosphate + UMP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl, 10 mM MgCl2, 8 µg/ml membrane protein
PH: 8.9
Temperature: 25

Pathways

pathway id name
BioCyc:META_PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
BioCyc:ECO_PWY-7206 pyrimidine deoxyribonucleotides dephosphorylation
BioCyc:ECO_PWY-7187 pyrimidine deoxyribonucleotides de novo biosynthesis II
BioCyc:MOUSE_PWY3DJ-81 riboflavin, FMN and FAD transformations
BioCyc:ECOL316407_PWY-7187 pyrimidine deoxyribonucleotides de novo biosynthesis II
BioCyc:ECOL316407_PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis I
BioCyc:META_PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis I
BioCyc:META_PWY-7206 pyrimidine deoxyribonucleotides dephosphorylation
BioCyc:ECO_PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis I
BioCyc:META_PWY-7187 pyrimidine deoxyribonucleotides de novo biosynthesis II
BioCyc:ECO_PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
PathBank:SMP0000959 Pyrimidine Metabolism
Reactome:R-HSA-9748787 Azathioprine ADME
Reactome:R-MMU-9748784 Drug ADME
Reactome:R-HSA-9748784 Drug ADME
Reactome:R-MMU-9748787 Azathioprine ADME
Reactome:R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins
Reactome:R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-HSA-199220 Vitamin B5 (pantothenate) metabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-2393930 Phosphate bond hydrolysis by NUDT proteins
Reactome:R-MMU-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-RNO-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-HSA-74259 Purine catabolism
Reactome:R-HSA-196854 Metabolism of vitamins and cofactors
Reactome:R-HSA-196843 Vitamin B2 (riboflavin) metabolism
Reactome:R-MMU-74259 Purine catabolism
Reactome:R-MMU-196854 Metabolism of vitamins and cofactors
Reactome:R-MMU-196843 Vitamin B2 (riboflavin) metabolism
Reactome:R-RNO-196854 Metabolism of vitamins and cofactors
Reactome:R-RNO-196843 Vitamin B2 (riboflavin) metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-15869 Nucleotide metabolism
Reactome:R-HSA-8956319 Nucleotide catabolism
Reactome:R-MMU-15869 Nucleotide metabolism
Reactome:R-MMU-8956319 Nucleotide catabolism
PathBank:SMP0000070 Riboflavin Metabolism
PathBank:SMP0000027 Pantothenate and CoA Biosynthesis
PathBank:SMP0000048 Nicotinate and Nicotinamide Metabolism