EC: 3.1.6.13

iduronate-2-sulfatase (L-iduronate-2-sulfate 2-sulfohydrolase)

enzyme lambda metabolic reaction experiment
uniprot:P22304 [iduronate-2-sulfatase(Enzyme) wildtype formA]

O_(alpha_L_Idopyranosyluronic_acid_2_sulfate)_(1_>4)_2,5_anhydro_D_mannitol_6_sulfate + H2O -> Sulfate + O_(alpha_L_Idopyranosyluronic_acid)_(1_>4)_2,5_anhydro_D_mannitol_6_sulfate		 (( (Vmax * S) ) / (S + Km)) buffer: 0.1 M Sodium acetate
PH: 5
Temperature: 37
uniprot:P22304 [iduronate-2-sulfatase(Enzyme) wildtype formB]

O_(alpha_L_Idopyranosyluronic_acid_2_sulfate)_(1_>4)_2,5_anhydro_D_mannitol_6_sulfate + H2O -> O_(alpha_L_Idopyranosyluronic_acid)_(1_>4)_2,5_anhydro_D_mannitol_6_sulfate + Sulfate		 (( (Vmax * S) ) / (S + Km)) buffer: 0.1 M Sodium acetate
PH: 5
Temperature: 37

Pathways

pathway id name
Reactome:R-HSA-1630316 Glycosaminoglycan metabolism
Reactome:R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism
Reactome:R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-1630316 Glycosaminoglycan metabolism
Reactome:R-MMU-1638091 Heparan sulfate/heparin (HS-GAG) metabolism
Reactome:R-MMU-1793185 Chondroitin sulfate/dermatan sulfate metabolism
Reactome:R-HSA-71387 Carbohydrate metabolism
Reactome:R-HSA-2024096 HS-GAG degradation
Reactome:R-HSA-2024101 CS/DS degradation
Reactome:R-MMU-2024096 HS-GAG degradation
Reactome:R-MMU-2024101 CS/DS degradation
Reactome:R-MMU-71387 Carbohydrate metabolism
Reactome:R-HSA-1430728 Metabolism