gpgS - Mycobacterium tuberculosis H37Rv

Probable glucosyl-3-phosphoglycerate synthase GpgS

3D-structure Calcium Cobalt Glycosyltransferase Iron Magnesium Manganese Metal-binding Reference proteome Transferase

> gpgS - Mycobacterium tuberculosis H37Rv [Probable glucosyl-3-phosphoglycerate synthase GpgS]
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统计信息
序列长度 0
疏水性残基 0
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Metadata

Organism Source: 83332 - Mycobacterium tuberculosis H37Rv
EC Number: 2.4.1.266
Cluster:
Registry Model:

Reactions

reaction id name note
KEGG:R09663 NDP-glucose:3-phospho-D-glycerate 2-alpha-D-glucosyltransferase NDP-glucose + 3-Phospho-D-glycerate <=> NDP + 2-O-(alpha-D-Glucopyranosyl)-3-phospho-D-glycerate
Rhea:RHEA:31312 ADP-α-D-glucose + (2R)-3-phosphoglycerate => (2R)-2-O-(α-D-glucopyranosyl)-3-phospho-glycerate + ADP + H+
Rhea:RHEA:31313 (2R)-2-O-(α-D-glucopyranosyl)-3-phospho-glycerate + ADP + H+ => ADP-α-D-glucose + (2R)-3-phosphoglycerate
Rhea:RHEA:31314 ADP-α-D-glucose + (2R)-3-phosphoglycerate <=> (2R)-2-O-(α-D-glucopyranosyl)-3-phospho-glycerate + ADP + H+
Rhea:RHEA:31316 GDP-D-glucose + (2R)-3-phosphoglycerate => (2R)-2-O-(α-D-glucopyranosyl)-3-phospho-glycerate + GDP + H+
Rhea:RHEA:31317 (2R)-2-O-(α-D-glucopyranosyl)-3-phospho-glycerate + GDP + H+ => GDP-D-glucose + (2R)-3-phosphoglycerate
Rhea:RHEA:31318 GDP-D-glucose + (2R)-3-phosphoglycerate <=> (2R)-2-O-(α-D-glucopyranosyl)-3-phospho-glycerate + GDP + H+
Rhea:RHEA:31320 (2R)-3-phosphoglycerate + UDP-α-D-glucose => (2R)-2-O-(α-D-glucopyranosyl)-3-phospho-glycerate + UDP + H+
Rhea:RHEA:31321 (2R)-2-O-(α-D-glucopyranosyl)-3-phospho-glycerate + UDP + H+ => (2R)-3-phosphoglycerate + UDP-α-D-glucose
Rhea:RHEA:31322 (2R)-3-phosphoglycerate + UDP-α-D-glucose <=> (2R)-2-O-(α-D-glucopyranosyl)-3-phospho-glycerate + UDP + H+
Rhea:RHEA:47245 an NDP-α-D-glucose + (2R)-3-phosphoglycerate => (2R)-2-O-(α-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H+
Rhea:RHEA:47246 (2R)-2-O-(α-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H+ => an NDP-α-D-glucose + (2R)-3-phosphoglycerate
Rhea:RHEA:47247 an NDP-α-D-glucose + (2R)-3-phosphoglycerate <=> (2R)-2-O-(α-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H+
BioCyc:RXN-8851 a NDP-glucose glucosyl-3-phosphoglycerate synthase
BioCyc:RXN-21298 ADP-D-GLUCOSE + G3P --> CPD-9189 + ADP + PROTON The enzyme is involved in biosynthesis of 2-(α-D-glucopyranosyl)-D-glycerate via the two-step pathway in which glucosyl-3-phosphoglycerate synthase catalyses the conversion of |FRAME: GDP-D-GLUCOSE| and |FRAME: G3P| into |FRAME: CPD-9189|, which is then converted to |FRAME: CPD-9190| by (|FRAME: RXN-8852 "EC 3.1.3.-"|), glucosyl-3-phosphoglycerate phosphatase. The activity is dependent on divalent cations (Mn2+, Co2+, or Mg2+). The enzyme from |FRAME: TAX-309805| shows moderate flexibility on the sugar donor concerning the nucleotide moiety (UDP-glucose, ADP-glucose, GDP-glucose) but is strictly specific for glucose. The enzyme is also strictly specific for 3-phospho-D-glycerate as acceptor |CITS: [17189358]|. The enzyme from |FRAME: TAX-29291| is strictly specific for GDP-glucose and 3-phospho-D-glycerate |CITS: [16428406]|. This enzyme catalyses the first glucosylation step in methylglucose lipopolysaccharide biosynthesis in mycobacteria |CITS: [19015727][19052364]|.
BioCyc:RXN-12041 UDP-glucose glucosyl-3-phosphoglycerate synthase The enzyme is involved in biosynthesis of 2-(α-D-glucopyranosyl)-D-glycerate via the two-step pathway in which glucosyl-3-phosphoglycerate synthase catalyses the conversion of |FRAME: GDP-D-GLUCOSE| and |FRAME: G3P| into |FRAME: CPD-9189|, which is then converted to |FRAME: CPD-9190| by (|FRAME: RXN-8852 "EC 3.1.3.-"|), glucosyl-3-phosphoglycerate phosphatase. The activity is dependent on divalent cations (Mn2+, Co2+, or Mg2+). The enzyme from |FRAME: TAX-309805| shows moderate flexibility on the sugar donor concerning the nucleotide moiety (UDP-glucose, ADP-glucose, GDP-glucose) but is strictly specific for glucose. The enzyme is also strictly specific for 3-phospho-D-glycerate as acceptor |CITS: [17189358]|. The enzyme from |FRAME: TAX-29291| is strictly specific for GDP-glucose and 3-phospho-D-glycerate |CITS: [16428406]|. This enzyme catalyses the first glucosylation step in methylglucose lipopolysaccharide biosynthesis in mycobacteria |CITS: [19015727][19052364]|.
BioCyc:RXN-12038 GDP-glucose glycosyl-3-phosphoglycerater synthase The enzyme is involved in biosynthesis of 2-(α-D-glucopyranosyl)-D-glycerate via the two-step pathway in which glucosyl-3-phosphoglycerate synthase catalyses the conversion of |FRAME: GDP-D-GLUCOSE| and |FRAME: G3P| into |FRAME: CPD-9189|, which is then converted to |FRAME: CPD-9190| by (|FRAME: RXN-8852 "EC 3.1.3.-"|), glucosyl-3-phosphoglycerate phosphatase. The activity is dependent on divalent cations (Mn2+, Co2+, or Mg2+). The enzyme from |FRAME: TAX-309805| shows moderate flexibility on the sugar donor concerning the nucleotide moiety (UDP-glucose, ADP-glucose, GDP-glucose) but is strictly specific for glucose. The enzyme is also strictly specific for 3-phospho-D-glycerate as acceptor |CITS: [17189358]|. The enzyme from |FRAME: TAX-29291| is strictly specific for GDP-glucose and 3-phospho-D-glycerate |CITS: [16428406]|. This enzyme catalyses the first glucosylation step in methylglucose lipopolysaccharide biosynthesis in mycobacteria |CITS: [19015727][19052364]|.

Pathways

pathway id name
BioCyc:MTBH37RV_PWY-6686 mannosylglucosylglycerate biosynthesis I
BioCyc:MTBH37RV_PWY-5662 glucosylglycerate biosynthesis I