Noca_0157 - Nocardioides sp. JS614
DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase
> Noca_0157 - Nocardioides sp. JS614 [DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase]
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统计信息
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疏水性残基
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Legend
Metadata
Organism Source: 196162 - Nocardioides sp. JS614
EC Number: 3.2.2.23 / 4.2.99.18
Cluster:
Registry Model:
Reactions
| reaction id | name | note |
|---|---|---|
| BioCyc:4.2.99.18-RXN | DNA-containing-abasic-Sites --> 3-terminal-unsaturated-sugars + 5-Phospho-terminated-DNAs + PROTON | |
| BioCyc:RXN-20478 | a-thymine-glycol-in-DNA + WATER --> a-DNA-3-alpha-beta-unsaturated-aldehyde + 5-Phospho-DNA + CPD-18012 + PROTON | |
| BioCyc:RXN0-2601 | Damaged-DNA-Pyrimidine + WATER --> a-DNA-3-alpha-beta-unsaturated-aldehyde + 5-Phospho-terminated-DNAs + Modified-Bases + PROTON | Excision of the nucleobase lesion is a two-step process and involves formation of an enzyme-substrate Schiff base intermediate; subsequent DNA strand nicking occurs via a β-elimination leaving a 3'-terminal α,β-unsaturated aldehyde and a 5'-terminal phosphate. This reaction is catalysed by the Nth (HhH) family of bifunctional DNA glycosylases. |
| BioCyc:RXN-18435 | DNA-With-GO + WATER --> CPD-12427 + 5-Phospho-terminated-DNAs + 3-Prime-Phosphate-Terminated-DNAs + CPD-21221 + 2 PROTON | |
| BioCyc:RXN-21261 | a-uracil-in-DNA-I + WATER --> a-DNA-3-alpha-beta-unsaturated-aldehyde + 5-Phospho-terminated-DNAs + URACIL + PROTON | |
| BioCyc:RXN-21266 | a-purine-base-lesion-in-DNA + WATER --> 3-Prime-Phosphate-Terminated-DNAs + 5-Phospho-terminated-DNAs + CPD-21221 + Modified-Bases | Excision of the nucleobase lesion is a two-step process and involves formation of an enzyme-substrate Schiff base intermediate; subsequent DNA strand nicking occurs via a β,δ-elimination leaving a 3'-terminal phosphate and a 5'-terminal phosphate. This reaction is catalysed by the Fpg (MutM) family of bifunctional DNA glycosylases. |
| BioCyc:3.2.2.23-RXN | DNA-containing-diamino-hydro-formamidops + WATER --> CPD-16491 + 5-Phospho-terminated-DNAs + 3-Prime-Phosphate-Terminated-DNAs + CPD-21221 + 2 PROTON | |
| Rhea:RHEA:66593 | 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA => a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H+ | |
| Rhea:RHEA:66594 | a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H+ => 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA | |
| Rhea:RHEA:66595 | 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA <=> a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H+ |
Pathways
| pathway id | name |
|---|