mepS - Escherichia coli K-12
Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase
> mepS - Escherichia coli K-12 [Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase]
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Metadata
Organism Source: 83333 - Escherichia coli K-12
EC Number: 3.4.-.- / 3.4.17.13
Cluster:
Registry Model:
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R04313 | C03793 + 2 C00017<=>C05546 + 2 C00001 | multi-step reaction |
| KEGG:R04869 | C05552 + 2 C00012<=>C06250 + 2 C00001 | Biocytin + 2 Peptide <=> Holo-[carboxylase] + 2 H2O |
| KEGG:R10891 | C20917 + C00001<=>C20918 + C00188 | putative tabtoxin peptidase |
| BioCyc:RXN-22576 | CPD-24805 + WATER --> A-PEPTIDOGLYCAN-MDAP-TRIPEPTIDE + GLY | |
| BioCyc:RXN-16664 | CPD-17926 + WATER --> CPD-17968 + D-ALANINE | This reaction may also be catalysed by the L,D-transpeptidases LdtA, LdtB, LdtC and LdtE |CITS: [18456808]|. |
| BioCyc:RXN0-5407 | CPD0-1185 + WATER --> A-PEPTIDOGLYCAN-MDAP-TRIPEPTIDE + CPD-24859 | This reaction represents hydrolysis of meso-DAP-meso-DAP (3 → 3) cross-links in peptidoglycan (see |CITS: [23066944]| for nomenclature of endopeptidase activity in E. coli K-12). |
| BioCyc:RXN0-5227 | CPD0-1082 + WATER --> L-ALA-GAMMA-D-GLU-DAP + D-ALANINE | |
| BioCyc:RXN-22575 | CPD0-1171 + WATER --> a-murein-lipoprotein + A-PEPTIDOGLYCAN-MDAP-TRIPEPTIDE | |
| BioCyc:RXN0-3461 | CPD0-2579 + WATER --> CPD-17931 + CPD-17986 | This reaction represents DD endopeptidase activity - hydrolysis of the meso-diaminopimelyl-D-alanyl bond in cross-linked peptidoglycan (see |CITS: [23066944]| for nomenclature of endopeptidase activity in E. coli K-12). |
| BioCyc:RXN0-2061 | UDP-MURNAC-TETRAPEPTIDE + WATER --> D-ALANINE + UDP-AAGM-DIAMINOHEPTANEDIOATE | |
| Rhea:RHEA:48689 | N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-meso-2,6-diaminoheptanedioyl-D-alanine + H2O => N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-meso-2,6-diaminoheptanedioate + D-alanine | |
| Rhea:RHEA:48690 | N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-meso-2,6-diaminoheptanedioate + D-alanine => N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-meso-2,6-diaminoheptanedioyl-D-alanine + H2O | |
| Rhea:RHEA:48691 | N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-meso-2,6-diaminoheptanedioyl-D-alanine + H2O <=> N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-meso-2,6-diaminoheptanedioate + D-alanine | |
| Rhea:RHEA:83268 | UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine + H2O => UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate + D-alanine | |
| Rhea:RHEA:83269 | UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate + D-alanine => UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine + H2O | |
| Rhea:RHEA:83270 | UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine + H2O <=> UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate + D-alanine | |
| Rhea:RHEA:83272 | N-acetyl-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine + H2O => N-acetyl-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanine | |
| Rhea:RHEA:83273 | N-acetyl-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanine => N-acetyl-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine + H2O | |
| Rhea:RHEA:83274 | N-acetyl-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine + H2O <=> N-acetyl-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanine | |
| BioCyc:3.4.17.13-RXN | CPD-13359 + WATER --> CPD-13360 + D-ALANINE | This enzyme catalyzes hydrolysis of the bond: N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-Ala-D-glutamyl-6-carboxy-L-lysyl-|-D-alanine.Variants are known from various microorganisms. Involved in peptidoglycan synthesis, catalysing both decarboxylation and transpeptidation. Stimulated by divalent cations such as Mg2+ and Ca2+, but not by Zn2+. Inhibited by thiol-blocking reagents, but unaffected by penicillin |
Pathways
| pathway id | name |
|---|---|
| BioCyc:META_PWY0-1261 | anhydromuropeptides recycling I |
| BioCyc:META_PWY0-1546 | muropeptide degradation |
| BioCyc:ECO_PWY0-1546 | muropeptide degradation |
| BioCyc:ECOL316407_PWY0-1261 | anhydromuropeptides recycling |
| BioCyc:ECO_PWY0-1261 | anhydromuropeptides recycling I |