L-cysteine biosynthesis VI (from L-methionine)

Doherty NC, Shen F, Halliday NM, Barrett DA, Hardie KR, Winzer K, Atherton JC. In Helicobacter pylori, LuxS is a key enzyme in cysteine provision through a reverse transsulfuration pathway. J Bacteriol. 2010 Mar;192(5):1184–92. PMID: 20061483; PMCID: PMC2820867.

Metabolites

(S)-4,5-Dihydroxypentane-2,3-dione

Formula: C5H8O4 (132.0422568)

CAS ID: 710324-30-4

Adenine

Formula: C5H5N5 (135.054493)

CAS ID: 73-24-5

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

succinate(2-)

Formula: C4H4O4 (116.01095839999999)

CAS ID: 56-14-4

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:



Enzyme

EC Number name full name note
2.5.1.47 cysteine synthase O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
2.5.1.48 cystathionine gamma-synthase O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
2.5.1.6 methionine adenosyltransferase ATP:L-methionine S-adenosyltransferase
3.2.2.30 aminodeoxyfutalosine nucleosidase 6-amino-6-deoxyfutalosine ribohydrolase
3.2.2.9 adenosylhomocysteine nucleosidase S-adenosyl-L-homocysteine homocysteinylribohydrolase
4.4.1.21 S-ribosylhomocysteine lyase S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]


Proteins

Protein ID name full name
O24915 mtnN Aminodeoxyfutalosine nucleosidase
O24931 luxS S-ribosylhomocysteine lyase
P56067 cysM Cysteine synthase
P56069 metB Cystathionine gamma-synthase
P56460 metK S-adenosylmethionine synthase