tetrapyrrole biosynthesis I (from glutamate)

Von Wettstein D, Gough S, Kannangara CG. Chlorophyll Biosynthesis. Plant Cell. 1995 Jul;7(7):1039–57. PMID: 12242396; PMCID: PMC160907.; Warren MJ, Scott AI. Tetrapyrrole assembly and modification into the ligands of biologically functional cofactors. Trends Biochem Sci. 1990 Dec;15(12):486–91. doi: 10.1016/0968-0004(90)90304-t. PMID: 2077690.

Metabolites

Cadmium

Formula: Cd (113.903361)

CAS ID: 7440-43-9

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydroxylamine

Formula: NH3O (33.0214628)

CAS ID: 7803-49-8

Mercury(2+)

Formula: Hg (201.970632)

CAS ID: 14302-87-5

Silver

Formula: Ag (106.905095)

CAS ID: 7440-22-4

Sodium cation

Formula: Na (22.98977)

CAS ID: 17341-25-2

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.2.1.70 glutamyl-tRNA reductase L-glutamate-semialdehyde:NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)
2.5.1.61 hydroxymethylbilane synthase porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
4.2.1.24 porphobilinogen synthase 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)
4.2.1.75 uroporphyrinogen-III synthase hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)
5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase (S)-4-amino-5-oxopentanoate 4,5-aminomutase


Proteins

Protein ID name full name