superpathway of heme biosynthesis

Camadro J, Labbe P. Cloning and Characterization of the Yeast HEM14 Gene Coding for Protoporphyrinogen Oxidase, the Molecular Target of Diphenyl Ether-type Herbicides. Journal of Biological Chemistry. 1996 Apr;271(15):9120–8. doi: 10.1074/jbc.271.15.9120.; Abbas A, Labbe-Bois R. Structure-function studies of yeast ferrochelatase. Identification and functional analysis of amino acid substitutions that increase Vmax and the KM for both substrates. Journal of Biological Chemistry. 1993 Apr;268(12):8541–6. doi: 10.1016/s0021-9258(18)52909-4.; Felix F, Brouillet N. Purification and properties of uroporphyrinogen decarboxylase from Saccharomyces cerevisiae. Yeast uroporphyrinogen decarboxylase. Eur J Biochem. 1990 Mar 10;188(2):393–403. doi: 10.1111/j.1432-1033.1990.tb15416.x. PMID: 2180703.; Zagorec M, Buhler JM, Treich I, Keng T, Guarente L, Labbe-Bois R. Isolation, sequence, and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase. Journal of Biological Chemistry. 1988 Jul;263(20):9718–24. doi: 10.1016/s0021-9258(19)81577-6.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7



Enzyme

EC Number name full name note
1.3.3.3 coproporphyrinogen oxidase coproporphyrinogen:oxygen oxidoreductase (decarboxylating)
1.3.3.4 protoporphyrinogen oxidase protoporphyrinogen-IX:oxygen oxidoreductase
2.3.1.37 5-aminolevulinate synthase succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
2.5.1.61 hydroxymethylbilane synthase porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
4.1.1.37 uroporphyrinogen decarboxylase uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)
4.2.1.24 porphobilinogen synthase 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)
4.2.1.75 uroporphyrinogen-III synthase hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)
4.98.1.1 protoporphyrin ferrochelatase protoheme ferro-lyase (protoporphyrin-forming)


Proteins

Protein ID name full name
P05373 HEM2 Delta-aminolevulinic acid dehydratase
P06174 HEM4 Uroporphyrinogen-III synthase
P09950 HEM1 5-aminolevulinate synthase, mitochondrial
P11353 HEM13 Oxygen-dependent coproporphyrinogen-III oxidase
P16622 HEM15 Ferrochelatase, mitochondrial
P28789 HEM3 Porphobilinogen deaminase
P32347 HEM12 Uroporphyrinogen decarboxylase
P40012 HEM14 Protoporphyrinogen oxidase