enterobactin biosynthesis

Crosa JH, Walsh CT. Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria. Microbiol Mol Biol Rev. 2002 Jun;66(2):223–49. doi: 10.1128/mmbr.66.2.223-249.2002.; Keating TA, Marshall CG, Walsh CT. Reconstitution and characterization of the Vibrio cholerae vibriobactin synthetase from VibB, VibE, VibF, and VibH. Biochemistry. 2000 Dec 19;39(50):15522–30. doi: 10.1021/bi0016523. PMID: 11112538.

Metabolites

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

Enterochelin

Formula: C30H27N3O15 (669.1442112000001)

CAS ID: 28384-96-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

2,3-dihydroxybenzoate

Formula: C7H5O4 (153.018783)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
2.7.8.-
1.3.1.28 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (2S,3S)-2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase
3.3.2.1 isochorismatase isochorismate pyruvate-hydrolase
5.4.4.2 isochorismate synthase isochorismate hydroxymutase
6.2.1.72 L-serine-[L-seryl-carrier protein] ligase L-serine:[L-seryl-carrier protein] ligase (AMP-forming)
6.3.2.14 enterobactin synthase 2,3-dihydroxybenzoate:L-serine ligase


Proteins

Protein ID name full name
P0ADI4 entB Enterobactin synthase component B
P0AEJ2 entC Isochorismate synthase EntC
P11454 entF Enterobactin synthase component F
P15047 entA 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
P19925 entD Enterobactin synthase component D