(aminomethyl)phosphonate degradation
Hove-Jensen B, Zechel DL, Jochimsen B. Utilization of glyphosate as phosphate source: biochemistry and genetics of bacterial carbon-phosphorus lyase. Microbiol Mol Biol Rev. 2014 Mar;78(1):176–97. PMID: 24600043; PMCID: PMC3957732.; Kamat SS, Williams HJ, Raushel FM. Intermediates in the transformation of phosphonates to phosphate by bacteria. Nature. 2011 Nov 16;480(7378):570–3. doi: 10.1038/nature10622.; He SM, Wathier M, Podzelinska K, Wong M, McSorley FR, Asfaw A, Hove-Jensen B, Jia Z, Zechel DL. Structure and mechanism of PhnP, a phosphodiesterase of the carbon-phosphorus lyase pathway. Biochemistry. 2011 Oct 11;50(40):8603–15. doi: 10.1021/bi2005398. PMID: 21830807.; Hove-Jensen B, McSorley FR, Zechel DL. Physiological role of phnP-specified phosphoribosyl cyclic phosphodiesterase in catabolism of organophosphonic acids by the carbon-phosphorus lyase pathway. J Am Chem Soc. 2011 Mar 16;133(10):3617–24. doi: 10.1021/ja1102713. PMID: 21341651.; Podzelinska K, He S, Wathier M, Yakunin A, Proudfoot M, Hove-Jensen B, Zechel DL, Jia Z. Structure of PhnP, a Phosphodiesterase of the Carbon-Phosphorus Lyase Pathway for Phosphonate Degradation. Journal of Biological Chemistry. 2009 Jun;284(25):17216–26. doi: 10.1074/jbc.m808392200.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.3.1.- | |||
| 2.3.1.280 | (aminoalkyl)phosphonate N-acetyltransferase | acetyl-CoA:(aminomethyl)phosphonate N-acetyltransferase | |
| 2.4.2.7 | adenine phosphoribosyltransferase | AMP:diphosphate phospho-D-ribosyltransferase | |
| 2.7.4.23 | ribose 1,5-bisphosphate phosphokinase | ATP:ribose-1,5-bisphosphate phosphotransferase | |
| 2.7.8.37 | alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase | ATP:methylphosphonate 5-triphosphoribosyltransferase | |
| 3.1.3.1 | alkaline phosphatase | phosphate-monoester phosphohydrolase (alkaline optimum) | |
| 3.1.4.55 | phosphoribosyl 1,2-cyclic phosphate phosphodiesterase | 5-phospho-alpha-D-ribose 1,2-cyclic phosphate 2-phosphohydrolase (alpha-D-ribose 1,5-bisphosphate-forming) | |
| 3.6.1.1 | inorganic diphosphatase | diphosphate phosphohydrolase | |
| 3.6.1.63 | alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase | alpha-D-ribose-1-methylphosphonate-5-triphosphate diphosphohydrolase | |
| 4.7.1.1 | alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase | alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane forming) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P00634 | phoA | Alkaline phosphatase |
| P0A7A9 | ppa | Inorganic pyrophosphatase |
| P16679 | phnL | Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL |
| P16685 | phnG | Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG |
| P16686 | phnH | Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH |
| P16687 | phnI | Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI |
| P16688 | phnJ | Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase |
| P16689 | phnM | Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase |
| P16690 | phnN | Ribose 1,5-bisphosphate phosphokinase PhnN |
| P16691 | phnO | Aminoalkylphosphonate N-acetyltransferase |
| P16692 | phnP | Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase |
| P69503 | apt | Adenine phosphoribosyltransferase |