4-hydroxyproline degradation
Knight J, Holmes RP. Mitochondrial Hydroxyproline Metabolism: Implications for Primary Hyperoxaluria. Am J Nephrol. 2005;25(2):171–5. doi: 10.1159/000085409.; Takayama T, Fujita K, Suzuki K, Sakaguchi M, Fujie M, Nagai E, Watanabe S, Ichiyama A, Ogawa Y. Control of oxalate formation from L-hydroxyproline in liver mitochondria. J Am Soc Nephrol. 2003 Apr;14(4):939–46. doi: 10.1097/01.asn.0000059310.67812.4f. PMID: 12660328.; Adams E, Frank L. Metabolism of proline and the hydroxyprolines. Annu Rev Biochem. 1980;49():1005–61. doi: 10.1146/annurev.bi.49.070180.005041. PMID: 6250440.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.2.1.88 | L-glutamate gamma-semialdehyde dehydrogenase | L-glutamate gamma-semialdehyde:NAD+ oxidoreductase | |
| 1.5.5.2 | proline dehydrogenase | L-proline:quinone oxidoreductase | |
| 1.5.5.3 | hydroxyproline dehydrogenase | trans-4-hydroxy-L-proline:quinone oxidoreductase | |
| 2.6.1.1 | aspartate transaminase | L-aspartate:2-oxoglutarate aminotransferase | |
| 2.6.1.7 | kynurenine-oxoglutarate transaminase | L-kynurenine:2-oxoglutarate aminotransferase | |
| 4.1.3.16 | 4-Hydroxy-2-oxoglutarate aldolase | 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming) |
Proteins
| Protein ID | name | full name |
|---|