4-hydroxyproline degradation

Knight J, Holmes RP. Mitochondrial Hydroxyproline Metabolism: Implications for Primary Hyperoxaluria. Am J Nephrol. 2005;25(2):171–5. doi: 10.1159/000085409.; Takayama T, Fujita K, Suzuki K, Sakaguchi M, Fujie M, Nagai E, Watanabe S, Ichiyama A, Ogawa Y. Control of oxalate formation from L-hydroxyproline in liver mitochondria. J Am Soc Nephrol. 2003 Apr;14(4):939–46. doi: 10.1097/01.asn.0000059310.67812.4f. PMID: 12660328.; Adams E, Frank L. Metabolism of proline and the hydroxyprolines. Annu Rev Biochem. 1980;49():1005–61. doi: 10.1146/annurev.bi.49.070180.005041. PMID: 6250440.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

glyoxylate

Formula: C2HO3 (72.9925696)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase L-glutamate gamma-semialdehyde:NAD+ oxidoreductase
1.5.5.2 proline dehydrogenase L-proline:quinone oxidoreductase
1.5.5.3 hydroxyproline dehydrogenase trans-4-hydroxy-L-proline:quinone oxidoreductase
2.6.1.1 aspartate transaminase L-aspartate:2-oxoglutarate aminotransferase
2.6.1.7 kynurenine-oxoglutarate transaminase L-kynurenine:2-oxoglutarate aminotransferase
4.1.3.16 4-Hydroxy-2-oxoglutarate aldolase 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)


Proteins

Protein ID name full name