L-threonine degradation III (to methylglyoxal)
Epperly BR, Dekker EE. Inactivation of Escherichia coli L-threonine dehydrogenase by 2,3-butanedione. Evidence for a catalytically essential arginine residue. J Biol Chem. 1989 Nov 05;264(31):18296–301. PMID: 2681195.; Boylan SA, Dekker EE. Growth, enzyme levels, and some metabolic properties of an Escherichia coli mutant grown on L-threonine as the sole carbon source. J Bacteriol. 1983 Oct;156(1):273–80. doi: 10.1128/jb.156.1.273-280.1983.; Boylan SA, Dekker EE. L-threonine dehydrogenase. Purification and properties of the homogeneous enzyme from Escherichia coli K-12. Journal of Biological Chemistry. 1981 Feb;256(4):1809–15. doi: 10.1016/s0021-9258(19)69880-7.; Komatsubara S, Murata K, Kisumi M, Chibata I. Threonine degradation by Serratia marcescens. J Bacteriol. 1978 Aug;135(2):318–23. doi: 10.1128/jb.135.2.318-323.1978.; Higgins IJ, Turner JM, Willetts AJ. Enzyme mechanism of aminoacetone metabolism by micro-organisms. Nature. 1967 Aug 19;215(5103):887–8. doi: 10.1038/215887a0. PMID: 4292865.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.1 | alcohol dehydrogenase | alcohol:NAD+ oxidoreductase | |
| 1.1.1.103 | L-threonine 3-dehydrogenase | L-threonine:NAD+ oxidoreductase | |
| 1.4.3.21 | primary-amine oxidase | primary-amine:oxygen oxidoreductase (deaminating) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P07913 | tdh | L-threonine 3-dehydrogenase |
| P37686 | yiaY | Probable alcohol dehydrogenase |
| P46883 | tynA | Primary amine oxidase |