2-oxobutanoate degradation I

Paxton R, Scislowski PW, Davis EJ, Harris RA. Role of branched-chain 2-oxo acid dehydrogenase and pyruvate dehydrogenase in 2-oxobutyrate metabolism. Biochem J. 1986 Mar 01;234(2):295–303. PMID: 3718468; PMCID: PMC1146565.

Metabolites

Cadmium

Formula: Cd (113.903361)

CAS ID: 7440-43-9

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Cobalt ion

Formula: Co (58.933198)

CAS ID: 22541-53-3

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

2-oxobutanoate

Formula: C4H5O3 (101.02386800000001)

CAS ID:

biotinate

Formula: C10H15N2O3S (243.080334)

CAS ID:

octanoyl-CoA(4-)

Formula: C29H46N7O17P3S (889.1883656000001)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
1.8.1.4 dihydrolipoyl dehydrogenase protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2.3.1.168 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase 2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase
5.1.99.1 methylmalonyl-CoA epimerase methylmalonyl-CoA 2-epimerase
5.4.99.2 methylmalonyl-CoA mutase (R)-methylmalonyl-CoA CoA-carbonylmutase
6.4.1.3 propionyl-CoA carboxylase propanoyl-CoA:carbon-dioxide ligase (ADP-forming)


Proteins

Protein ID name full name