ethanol degradation I

Membrillo-Hernandez J, Echave P, Cabiscol E, Tamarit J, Ros J, Lin EC. Evolution of the adhE gene product of Escherichia coli from a functional reductase to a dehydrogenase. Genetic and biochemical studies of the mutant proteins. J Biol Chem. 2000 Oct 27;275(43):33869–75. doi: 10.1074/jbc.m005464200. PMID: 10922373.

Metabolites

Acetaldehyde

Formula: C2H4O (44.0262134)

CAS ID: 75-07-0

Aromatic aldehyde

Formula: C7H6O (106.0418626)

CAS ID: 100-52-7

Ethanol

Formula: C2H6O (46.0418626)

CAS ID: 64-17-5

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Fomepizole

Formula: C4H6N2 (82.05309559999999)

CAS ID: 7554-65-6

Guaiacol

Formula: C7H8O2 (124.05242679999999)

CAS ID: 90-05-1

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Pyrazole

Formula: C3H4N2 (68.0374464)

CAS ID: 288-13-1

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.1.1.1 alcohol dehydrogenase alcohol:NAD+ oxidoreductase
1.2.1.10 acetaldehyde dehydrogenase (acetylating) acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)
1.2.1.3 aldehyde dehydrogenase (NAD+) aldehyde:NAD+ oxidoreductase


Proteins

Protein ID name full name
P0A9Q7 adhE Bifunctional aldehyde-alcohol dehydrogenase AdhE
P33744 adhe1 Aldehyde dehydrogenase (NAD+)
P39451 adhP Alcohol dehydrogenase, propanol-preferring
P77580 mhpF Acetaldehyde dehydrogenase