Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.

Metabolites

3alpha,7alpha-Dihydroxy-5beta-cholestane

Formula: C27H48O2 (404.36541079999995)

CAS ID: 3862-26-8

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane

Formula: C27H48O3 (420.36032579999994)

CAS ID: 547-96-6

4-Cholesten-7alpha,12alpha-diol-3-one

Formula: C27H44O3 (416.3290274)

CAS ID: 1254-03-1

7alpha-Hydroxycholest-4-en-3-one

Formula: C27H44O2 (400.3341124)

CAS ID: 3862-25-7

7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one

Formula: C27H46O3 (418.34467659999996)

CAS ID: 547-97-7

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

cholate

Formula: C24H39O5 (407.2797344)

CAS ID: 298-43-1

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
3.1.2.2 palmitoyl-CoA hydrolase palmitoyl-CoA hydrolase


Proteins

Protein ID name full name
P41903 TES1 Peroxisomal acyl-coenzyme A thioester hydrolase 1