GABA synthesis, release, reuptake and degradation

Buddhala C, Hsu CC, Wu JY. A novel mechanism for GABA synthesis and packaging into synaptic vesicles. Neurochem Int. 2009 Jul;55(1-3):9–12. doi: 10.1016/j.neuint.2009.01.020. PMID: 19428801.; Bak LK, Schousboe A, Waagepetersen HS. The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer. Journal of Neurochemistry. 2006 Jun 19;98(3):641–53. doi: 10.1111/j.1471-4159.2006.03913.x.

Metabolites

Cl-

Formula: Cl (34.968853)

CAS ID: 16887-00-6

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Sodium cation

Formula: Na (22.98977)

CAS ID: 17341-25-2

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

succinate(2-)

Formula: C4H4O4 (116.01095839999999)

CAS ID: 56-14-4

4-oxobutanoate

Formula: C4H5O3 (101.02386800000001)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
4.1.1.15 glutamate decarboxylase L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)


Proteins

Protein ID name full name