vancomycin resistance II

Dutta I, Reynolds PE. The vanC-3 vancomycin resistance gene cluster of Enterococcus flavescens CCM 439. J Antimicrob Chemother. 2003 Mar;51(3):703–6. doi: 10.1093/jac/dkg131. PMID: 12615874.; Dutka-Malen S, Molinas C, Arthur M, Courvalin P. Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance. Gene. 1992 Mar 01;112(1):53–8. doi: 10.1016/0378-1119(92)90302-6. PMID: 1551598.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

pyridoxal 5'-phosphate(2-)

Formula: C8H8NO6P (245.0089238)

CAS ID:



Enzyme

EC Number name full name note
3.4.17.-
3.4.13.22 D-Ala-D-Ala dipeptidase
5.1.1.1 alanine racemase alanine racemase
6.3.2.35 D-alanine-D-serine ligase D-alanine:D-serine ligase (ADP-forming)


Proteins

Protein ID name full name
P29753 vanC1 Vancomycin C-type resistance protein VanC1
Q47720 vanC2 Vancomycin C-type resistance protein VanC2
Q9JN36 vanXYC Bifunctional D-Ala-D-Ala dipeptidase and D-Ala-D-Ala carboxypeptidase VanXYC
Q9X3P3 vanT Serine/alanine racemase