histidine biosynthesis

Metabolites

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.1.1.23 histidinol dehydrogenase L-histidinol:NAD+ oxidoreductase
2.4.2.17 ATP phosphoribosyltransferase 1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase
2.6.1.9 histidinol-phosphate transaminase L-histidinol-phosphate:2-oxoglutarate aminotransferase
3.5.4.19 phosphoribosyl-AMP cyclohydrolase 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase
3.6.1.31 phosphoribosyl-ATP diphosphatase 1-(5-phosphoribosyl)-ATP diphosphohydrolase
4.3.2.10 imidazole glycerol-phosphate synthase 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate-lyase (L-glutamine-hydrolysing; 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide-forming)


Proteins

Protein ID name full name
P60665 hisF Imidazole glycerol phosphate synthase subunit HisF
Q8X8T3 hisD Histidinol dehydrogenase
Q8X8T4 hisG ATP phosphoribosyltransferase
Q9S5G3 hisI Histidine biosynthesis bifunctional protein HisIE
Q9S5G6 hisC Histidinol-phosphate aminotransferase