O-linked glycosylation of mucins

Tarp MA, Clausen H. Mucin-type O-glycosylation and its potential use in drug and vaccine development. Biochimica et Biophysica Acta (BBA) - General Subjects. 2008 Mar;1780(3):546–63. doi: 10.1016/j.bbagen.2007.09.010.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

UDP-N-acetyl-D-galactosamine(2-)

Formula: C17H25N3O17P2 (605.0659180000001)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0



Enzyme

EC Number name full name note
2.4.1.-
2.4.1.102 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase UDP-N-acetyl-alpha-D-glucosamine:O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase UDP-alpha-D-galactose:N-acetyl-alpha-D-galactosaminyl-R beta-1,3-galactosyltransferase (configuration-inverting)
2.4.1.148 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R 6-beta-N-acetyl-D-glucosaminyltransferase
2.4.1.150 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminide 6-beta-N-acetylglucosaminyltransferase (configuration-inverting)
2.4.3.1 beta-galactoside alpha-(2,6)-sialyltransferase CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting)
2.4.3.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase


Proteins

Protein ID name full name