Bile acid and bile salt metabolism
Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology. 2004 Jan;126(1):322–42. doi: 10.1053/j.gastro.2003.06.005. PMID: 14699511.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 2003 Apr;83(2):633–71. doi: 10.1152/physrev.00027.2002. PMID: 12663868.; Javitt NB. Cholesterol, Hydroxycholesterols, and Bile Acids. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1147–53. doi: 10.1006/bbrc.2001.2013.
Metabolites
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane
Formula: C27H48O3 (420.36032579999994)
CAS ID: 547-96-6
3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane
Formula: C27H48O4 (436.3552408)
CAS ID: 862-53-3
7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one
Formula: C27H46O3 (418.34467659999996)
CAS ID: 547-97-7
7alpha,12alpha,26-Trihydroxy-5beta-cholestan-3-one
Formula: C27H46O4 (434.3395916)
CAS ID: 78094-12-9
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.14.18.- | |||
| 3.1.2.2 | palmitoyl-CoA hydrolase | palmitoyl-CoA hydrolase | |
| 7.2.2.2 | ABC-type Cd2+ transporter | ATP phosphohydrolase (ABC-type, heavy-metal-exporting) | |
| 7.6.2.3 | ABC-type glutathione-S-conjugate transporter | ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2] |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P39109 | YCF1 | Metal resistance protein YCF1 |
| P41903 | TES1 | Peroxisomal acyl-coenzyme A thioester hydrolase 1 |
| P53045 | ERG25 | C-4 methylsterol oxidase ERG25 |