peptidoglycan maturation (meso-diaminopimelate containing)
Turner RD, Mesnage S, Hobbs JK, Foster SJ. Molecular imaging of glycan chains couples cell-wall polysaccharide architecture to bacterial cell morphology. Nat Commun. 2018 Mar 28;9(1). doi: 10.1038/s41467-018-03551-y.; Pazos M, Peters K, Vollmer W. Robust peptidoglycan growth by dynamic and variable multi-protein complexes. Current Opinion in Microbiology. 2017 Apr;36():55–61. doi: 10.1016/j.mib.2017.01.006.; van Heijenoort J. Peptidoglycan hydrolases of Escherichia coli. Microbiol Mol Biol Rev. 2011 Dec;75(4):636–63. PMID: 22126997; PMCID: PMC3232740.; Vollmer W, Bertsche U. Murein (peptidoglycan) structure, architecture and biosynthesis in Escherichia coli. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2008 Sep;1778(9):1714–34. doi: 10.1016/j.bbamem.2007.06.007.
Metabolites
[(2S,3R,4R,6S)-6-[[(1S,2R,18R,19R,22R,34S,37R,40R,52S)-22-azaniumyl-64-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxy-6-[[(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-18,26,31,44,49-pentahydroxy-52-methoxycarbonyl-30-methyl-21,35,38,54,56,59-hexaoxo-47-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3(66),4,6(65),8,10,12(64),14(63),15,17(62),23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49-henicosaen-2-yl]oxy]-3-hydroxy-2-methyloxan-4-yl]azanium
Formula: C95H112N8O44+2 (2068.6772072)
CAS ID: 1404-55-3
2-[2-[[2-[[2-[[2-[[2-[[7-[[2-[[2-[[4-amino-2-[[21-[[6-azaniumyl-2-[[3-[[15-[[(Z)-2-[(2-azaniumyl-3-methylpentanoyl)amino]but-2-enoyl]amino]-12-butan-2-yl-9-methylidene-6-(2-methylpropyl)-5,8,11,14-tetraoxo-1-thia-4,7,10,13-tetrazacyclohexadecane-3-carbonyl]amino]-4-methyl-2,9,12-trioxo-5-thia-1,8,11-triazabicyclo[11.3.0]hexadecane-7-carbonyl]amino]hexanoyl]amino]-15,22-dimethyl-12-(2-methylpropyl)-9-(2-methylsulfanylethyl)-5,8,11,14,17,20-hexaoxo-1-thia-4,7,10,13,16,19-hexazacyclodocosane-3-carbonyl]amino]-4-oxobutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-6-azaniumylhexanoyl]amino]-14-(1H-imidazol-3-ium-5-ylmethyl)-4,8,20-trimethyl-3,6,12,15,21-pentaoxo-9,19-dithia-2,5,13,16,22-pentazabicyclo[9.9.2]docosane-17-carbonyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylbutanoyl]amino]prop-2-enoylamino]-6-azaniumylhexanoate
Formula: C143H234N42O37S7+4 (3355.5764234000003)
CAS ID:
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.-.-.- | |||
| 2.4.99.28 | peptidoglycan glycosyltransferase | [poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase | |
| 3.4.16.4 | serine-type D-Ala-D-Ala carboxypeptidase | ||
| 3.5.2.6 | beta-lactamase | beta-lactam hydrolase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P02918 | mrcA | Penicillin-binding protein 1A |
| P02919 | mrcB | Penicillin-binding protein 1B |
| P08506 | dacC | D-alanyl-D-alanine carboxypeptidase DacC |
| P0AAX8 | ybiS | Probable L,D-transpeptidase YbiS |
| P0AD65 | mrdA | Peptidoglycan D,D-transpeptidase MrdA |
| P0AD68 | ftsI | Peptidoglycan D,D-transpeptidase FtsI |
| P0AD70 | ampH | D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH |
| P0AEB2 | dacA | D-alanyl-D-alanine carboxypeptidase DacA |
| P22525 | ycbB | Probable L,D-transpeptidase YcbB |
| P33013 | dacD | D-alanyl-D-alanine carboxypeptidase DacD |
| P39176 | erfK | Probable L,D-transpeptidase ErfK/SrfK |
| P46022 | mtgA | Biosynthetic peptidoglycan transglycosylase |
| P75954 | ycfS | Probable L,D-transpeptidase YcfS |
| P76193 | ynhG | Probable L,D-transpeptidase YnhG |
| P76577 | pbpC | Penicillin-binding protein 1C |
| P77619 | yfeW | Putative D-alanyl-D-alanine carboxypeptidase |