(aminomethyl)phosphonate degradation

Hove-Jensen B, McSorley FR, Zechel DL. Catabolism and Detoxification of 1-Aminoalkylphosphonic Acids: N-Acetylation by the phnO Gene Product. PLoS ONE. 2012 Oct 03;7(10):e46416. doi: 10.1371/journal.pone.0046416.

Metabolites

5'-Deoxyadenosine

Formula: C10H13N5O3 (251.10183480000003)

CAS ID: 4754-39-6

Adenine

Formula: C5H5N5 (135.054493)

CAS ID: 73-24-5

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

Fluoride

Formula: F (18.9984032)

CAS ID: 7782-41-4

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

N-METHYLACETAMIDE

Formula: C3H7NO (73.0527612)

CAS ID: 79-16-3

dithionite(2-)

Formula: O4S2 (127.923804)

CAS ID: 14844-07-6

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate(3-)

Formula: C5H7O10P2 (288.9514482)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.-
2.3.1.280 (aminoalkyl)phosphonate N-acetyltransferase acetyl-CoA:(aminomethyl)phosphonate N-acetyltransferase
2.4.2.7 adenine phosphoribosyltransferase AMP:diphosphate phospho-D-ribosyltransferase
2.7.4.23 ribose 1,5-bisphosphate phosphokinase ATP:ribose-1,5-bisphosphate phosphotransferase
2.7.8.37 alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase ATP:methylphosphonate 5-triphosphoribosyltransferase
3.1.3.1 alkaline phosphatase phosphate-monoester phosphohydrolase (alkaline optimum)
3.1.4.55 phosphoribosyl 1,2-cyclic phosphate phosphodiesterase 5-phospho-alpha-D-ribose 1,2-cyclic phosphate 2-phosphohydrolase (alpha-D-ribose 1,5-bisphosphate-forming)
3.6.1.1 inorganic diphosphatase diphosphate phosphohydrolase
3.6.1.63 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase alpha-D-ribose-1-methylphosphonate-5-triphosphate diphosphohydrolase
4.7.1.1 alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane forming)


Proteins

Protein ID name full name
P00634 phoA Alkaline phosphatase
P0A7A9 ppa Inorganic pyrophosphatase
P16679 phnL Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL
P16685 phnG Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG
P16686 phnH Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH
P16687 phnI Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI
P16688 phnJ Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase
P16689 phnM Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase
P16690 phnN Ribose 1,5-bisphosphate phosphokinase PhnN
P16691 phnO Aminoalkylphosphonate N-acetyltransferase
P16692 phnP Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase
P69503 apt Adenine phosphoribosyltransferase