Blood group systems biosynthesis

Ewald DR, Sumner SC. Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med. 2016 Nov;8(6):517–35. PMID: 27599872; PMCID: PMC5061611.; Storry JR, Castilho L, Chen Q, Daniels G, Denomme G, Flegel WA, Gassner C, de Haas M, Hyland C, Keller M, Lomas-Francis C, Moulds JM, Nogues N, Olsson ML, Peyrard T, van der Schoot CE, Tani Y, Thornton N, Wagner F, Wendel S, Westhoff C, Yahalom V. International society of blood transfusion working party on red cell immunogenetics and terminology: report of the Seoul and London meetings. ISBT Science Series. 2016 Jun 27;11(2):118–22. doi: 10.1111/voxs.12280.; Rummel SK, Ellsworth RE. The role of the histoblood ABO group in cancer. Future Sci OA. 2016 Jun;2(2):FSO107. PMID: 28031957; PMCID: PMC5137991.; Meo SA, Rouq FA, Suraya F, Zaidi SZ. Association of ABO and Rh blood groups with type 2 diabetes mellitus. Eur Rev Med Pharmacol Sci. 2016;20(2):237–42. PMID: 26875891.; McCullough J. RBCs as targets of infection. Hematology Am Soc Hematol Educ Program. 2014 Dec 05;2014(1):404–9. doi: 10.1182/asheducation-2014.1.404. PMID: 25696886.; Liumbruno GM, Franchini M. Beyond immunohaematology: the role of the ABO blood group in human diseases. Blood Transfus. 2013 Oct;11(4):491–9. PMID: 24120598; PMCID: PMC3827391.; Tan SY, Graham C. Karl Landsteiner (1868-1943): originator of ABO blood classification. Singapore Med J. 2013 May;54(5):243–4. doi: 10.11622/smedj.2013099. PMID: 23716146.; Anstee DJ. The relationship between blood groups and disease. Blood. 2010 Jun 10;115(23):4635–43. doi: 10.1182/blood-2010-01-261859. PMID: 20308598.; Owen R. Karl Landsteiner and the first human marker locus. Genetics. 2000 Jul;155(3):995–8. PMID: 10880463; PMCID: PMC1461144.; Rios M, Bianco C. The role of blood group antigens in infectious diseases. Semin Hematol. 2000 Apr;37(2):177–85. doi: 10.1016/s0037-1963(00)90042-8. PMID: 10791886.; Landsteiner K. INDIVIDUAL DIFFERENCES IN HUMAN BLOOD. Science. 1931 Apr 17;73(1894):403–9. doi: 10.1126/science.73.1894.403. PMID: 17755773.

Metabolites

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

UDP-N-acetyl-D-galactosamine(2-)

Formula: C17H25N3O17P2 (605.0659180000001)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc

Formula: C31H52N2O23 (820.2960722)

CAS ID:

alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-D-GlcNAc

Formula: C26H45NO19 (675.258566)

CAS ID:



Enzyme

EC Number name full name note
2.4.1.-
2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase (configuration-inverting)
2.4.1.344 type 2 galactoside alpha-(1,2)-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
2.4.1.37 fucosylgalactoside 3-alpha-galactosyltransferase UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
2.4.1.40 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase
2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase
2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
2.4.3.6 N-acetyllactosaminide alpha-2,3-sialyltransferase CMP-N-acetyl-beta-neuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R (2->3)-N-acetyl-alpha-neuraminyltransferase (configuration-inverting)


Proteins

Protein ID name full name