Lewis blood group biosynthesis

Blanas A, Sahasrabudhe NM, Rodríguez E, van Kooyk Y, van Vliet SJ. Corrigendum: Fucosylated Antigens in Cancer: An Alliance Toward Tumor Progression, Metastasis, and Resistance to Chemotherapy. Front Oncol. 2018;8():150. PMID: 29795807; PMCID: PMC5958677.; Trinchera M, Aronica A, Dall'Olio F. Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal Cancers. Biology (Basel). 2017 Feb 23;6(1). PMID: 28241499; PMCID: PMC5372009.; Ewald DR, Sumner SC. Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med. 2016 Nov;8(6):517–35. PMID: 27599872; PMCID: PMC5061611.; Natoni A, Macauley MS, O’Dwyer ME. Targeting Selectins and Their Ligands in Cancer. Front. Oncol. 2016 Apr 18;6(). doi: 10.3389/fonc.2016.00093.; Cheung LS, Raman PS, Balzer EM, Wirtz D, Konstantopoulos K. Biophysics of selectin-ligand interactions in inflammation and cancer. Phys Biol. 2011 Feb;8(1):015013. doi: 10.1088/1478-3975/8/1/015013. PMID: 21301059.; Läubli H, Borsig L. Selectins promote tumor metastasis. Semin Cancer Biol. 2010 Jun;20(3):169–77. doi: 10.1016/j.semcancer.2010.04.005. PMID: 20452433.; MAGNANI J. The discovery, biology, and drug development of sialyl Lea and sialyl Lex. Archives of Biochemistry and Biophysics. 2004 Jun;426(2):122–31. doi: 10.1016/s0003-9861(04)00214-0.; Ley K. The role of selectins in inflammation and disease. Trends Mol Med. 2003 Jun;9(6):263–8. doi: 10.1016/s1471-4914(03)00071-6. PMID: 12829015.

Metabolites

UDP-N-acetyl-D-galactosamine(2-)

Formula: C17H25N3O17P2 (605.0659180000001)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc

Formula: C31H52N2O23 (820.2960722)

CAS ID:

alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-D-GlcNAc

Formula: C26H45NO19 (675.258566)

CAS ID:



Enzyme

EC Number name full name note
2.4.1.-
2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase (configuration-inverting)
2.4.1.344 type 2 galactoside alpha-(1,2)-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase
2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
2.4.3.6 N-acetyllactosaminide alpha-2,3-sialyltransferase CMP-N-acetyl-beta-neuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R (2->3)-N-acetyl-alpha-neuraminyltransferase (configuration-inverting)


Proteins

Protein ID name full name