D-galactose degradation IV

Mojzita D, Herold S, Metz B, Seiboth B, Richard P. l-xylo-3-Hexulose Reductase Is the Missing Link in the Oxidoreductive Pathway for d-Galactose Catabolism in Filamentous Fungi. Journal of Biological Chemistry. 2012 Jul;287(31):26010–8. doi: 10.1074/jbc.m112.372755.; Mojzita D, Koivistoinen OM, Maaheimo H, Penttilä M, Ruohonen L, Richard P. Identification of the galactitol dehydrogenase, LadB, that is part of the oxido-reductive D-galactose catabolic pathway in Aspergillus niger. Fungal Genet Biol. 2012 Feb;49(2):152–9. doi: 10.1016/j.fgb.2011.11.005. PMID: 22155165.; Koivistoinen OM, Richard P, Penttilä M, Ruohonen L, Mojzita D. Sorbitol dehydrogenase of Aspergillus niger, SdhA, is part of the oxido-reductive d-galactose pathway and essential for d-sorbitol catabolism. FEBS Letters. 2012 Jan 10;586(4):378–83. doi: 10.1016/j.febslet.2012.01.004.; Seiboth B, Metz B. Fungal arabinan and l-arabinose metabolism. Applied Microbiology and Biotechnology. 2011 Jan 07;89(6):1665–73. doi: 10.1007/s00253-010-3071-8.; Kubicek CP, Mikus M, Schuster A, Schmoll M, Seiboth B. Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina. Biotechnology for Biofuels and Bioproducts. 2009 Sep 01;2(1):19. doi: 10.1186/1754-6834-2-19.

Metabolites

D-Galactose

Formula: C6H12O6 (180.0633852)

CAS ID: 59-23-4

D-Sorbitol

Formula: C6H14O6 (182.0790344)

CAS ID: 50-70-4

Galactitol

Formula: C6H14O6 (182.0790344)

CAS ID: 608-66-2

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.-
1.1.1.12 L-arabinitol 4-dehydrogenase L-arabinitol:NAD+ 4-oxidoreductase (L-xylulose-forming)


Proteins

Protein ID name full name
A2R6Y6 A2R6Y6_ASPNC Contig An16c0060, genomic contig
A2R6Z2 A2R6Z2_ASPNC D-xylulose reductase
G0RNA2 lxr4 L-xylo-3-hexulose reductase
Q876L8 xyl1 NAD(P)H-dependent D-xylose reductase xyl1
Q96V44 lad1 L-arabinitol 4-dehydrogenase