Daidzein (BioCAD00000009485)

blood feces urine plant natural products microbial natural products

Metabolite Card

Formula: C15H10O4 (254.0579)
SMILES: OC1=CC=C(C=C1)C1=COC2=C(C=CC(O)=C2)C1=O

Synonyms [en]

daidzein; 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 4',7-Dihydroxyisoflavone; 7,4'-Dihydroxyisoflavone; Daidzeol; 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Daidzein. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000009485). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Daidzein is one of several known isoflavones. Isoflavones compounds are found in a number of plants, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Up until recently, daidzein was considered to be one of the most important and most studied isoflavones, however more recently attention has shifted to isoflavone metabolites. Equol represents the main active product of daidzein metabolism, produced via specific microflora in the gut. The clinical effectiveness of soy isoflavones may be a function of the ability to biotransform soy isoflavones to the more potent estrogenic metabolite, equol, which may enhance the actions of soy isoflavones, owing to its greater affinity for estrogen receptors, unique antiandrogenic properties, and superior antioxidant activity. However, not all individuals consuming daidzein produce equol. Only approximately one-third to one-half of the population is able to metabolize daidzein to equol. This high variability in equol production is presumably attributable to interindividual differences in the composition of the intestinal microflora, which may play an important role in the mechanisms of action of isoflavones. But, the specific bacterial species in the colon involved in the production of equol are yet to be discovered. (PMID:18045128, 17579894). Daidzein is a biomarker for the consumption of soy beans and other soy products.

Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 486-66-8
  • PubChem: 5281708
  • ChEBI: ChEBI:28197
  • HMDB: HMDB0003312
  • LipidMaps: LMPK12050038
  • KEGG: C10208
  • BioCyc: DAIDZEIN
  • NCBI MeSH: daidzein
  • Wikipedia: Daidzein
  • DrugBank: DB13182
  • RefMet: RM0040198
  • MoNA: AU287401
  • MoNA: AU287402
  • MoNA: AU287403
  • MoNA: AU287404
  • MoNA: AU287405
  • MoNA: AU287406
  • MoNA: CCMSLIB00000078314
  • MoNA: CCMSLIB00000078858
  • MoNA: CCMSLIB00000078891
  • MoNA: FFF00070
  • MoNA: FFF00071
  • MoNA: FFF00072
  • MoNA: FFF00073
  • MoNA: FFF00074
  • MoNA: FFF00075
  • MoNA: FFF00076
  • MoNA: FiehnHILIC000296
  • MoNA: FiehnHILIC001140
  • MoNA: FiehnHILIC001867
  • MoNA: FiehnHILIC002657
  • MoNA: FiehnLib000799
  • MoNA: HMDB0003312_c_ms_2166
  • MoNA: HMDB0003312_ms_ms_2236
  • MoNA: HMDB0003312_ms_ms_2237
  • MoNA: HMDB0003312_ms_ms_2238
  • MoNA: HMDB0003312_ms_ms_285596
  • MoNA: HMDB0003312_ms_ms_285597
  • MoNA: LU093701
  • MoNA: LU093702
  • MoNA: LU093703
  • MoNA: LU093704
  • MoNA: LU093705
  • MoNA: LU093706
  • MoNA: LU093751
  • MoNA: LU093752
  • MoNA: LU093753
  • MoNA: LU093754
  • MoNA: LU093755
  • MoNA: LU093756
  • MoNA: MetaboBASE0043
  • MoNA: MetaboBASE0044
  • MoNA: MoNA003269
  • MoNA: NA000031
  • MoNA: NA000032
  • MoNA: NA000033
  • MoNA: NA000034
  • MoNA: NA000035
  • MoNA: NA002496
  • MoNA: NA002497
  • MoNA: NA002498
  • MoNA: NA002499
  • MoNA: NA002500
  • MoNA: NA002889
  • MoNA: NA002890
  • MoNA: NA002891
  • MoNA: NA002892
  • MoNA: NA002893
  • MoNA: NA003264
  • MoNA: NA003265
  • MoNA: NA003266
  • MoNA: NA003267
  • MoNA: NA003268
  • MoNA: NA003634
  • MoNA: NA003635
  • MoNA: NA003636
  • MoNA: NA003637
  • MoNA: NA003638
  • MoNA: OUF00155
  • MoNA: PB000821
  • MoNA: PB000841
  • MoNA: PB000842
  • MoNA: PB000861
  • MoNA: PB002425
  • MoNA: PB002426
  • MoNA: PB002427
  • MoNA: PB002428
  • MoNA: PM013601
  • MoNA: PM015808
  • MoNA: PR020020
  • MoNA: PR040007
  • MoNA: PR040008
  • MoNA: PR040009
  • MoNA: PR040010
  • MoNA: PR100225
  • MoNA: PR100637
  • MoNA: PR100638
  • MoNA: PR309180
  • MoNA: PR310855
  • MoNA: PS039701
  • MoNA: PS039702
  • MoNA: PS039703
  • MoNA: PS039704
  • MoNA: PT103970
  • MoNA: PT203970
  • MoNA: PT203973
  • MoNA: RIKENPlaSMA002625
  • MoNA: RIKENPlaSMA002631
  • MoNA: RIKENPlaSMA002637
  • MoNA: RIKENPlaSMA002643
  • MoNA: RIKENPlaSMA002649
  • MoNA: RIKENPlaSMA002655
  • MoNA: RIKENPlaSMA002661
  • MoNA: RIKENPlaSMA002667
  • MoNA: RIKENPlaSMA002673
  • MoNA: RIKENPlaSMA002679
  • MoNA: RIKENPlaSMA002685
  • MoNA: RIKENPlaSMA002691
  • MoNA: RIKENPlaSMA006284
  • MoNA: RIKENPlaSMA006291
  • MoNA: RIKENPlaSMA006298
  • MoNA: RIKENPlaSMA006305
  • MoNA: RIKENPlaSMA006311
  • MoNA: RIKENPlaSMA006318
  • MoNA: RIKENPlaSMA006324
  • MoNA: RIKENPlaSMA006331
  • MoNA: RIKENPlaSMA006338
  • MoNA: RIKENPlaSMA006345
  • MoNA: RIKENPlaSMA006352
  • MoNA: RIKENPlaSMA006359
  • MoNA: RP018101
  • MoNA: RP018102
  • MoNA: RP018103
  • MoNA: RP018111
  • MoNA: RP018112
  • MoNA: RP018113
  • MoNA: SM882802
  • MoNA: SM882851
  • MoNA: UF416301
  • MoNA: UF416302
  • MoNA: UF416303
  • MoNA: UF416304
  • MoNA: UF416351
  • MoNA: UF416352
  • MoNA: UF416353
  • MoNA: UF416354
  • MoNA: UF423901
  • MoNA: UF423902
  • MoNA: UF423903
  • MoNA: UF423904
  • MoNA: UF423951
  • MoNA: UF423952
  • MoNA: UF423953
  • MoNA: UF423954
  • MoNA: VF-NPL-LTQ000391
  • MoNA: VF-NPL-LTQ000392
  • MoNA: VF-NPL-LTQ003699
  • MoNA: VF-NPL-LTQ003700
  • MoNA: VF-NPL-LTQ003701
  • MoNA: VF-NPL-LTQ003702
  • MoNA: VF-NPL-QEHF013303
  • MoNA: VF-NPL-QEHF013304
  • MoNA: VF-NPL-QEHF013305
  • MoNA: VF-NPL-QEHF013306
  • MoNA: VF-NPL-QEHF013307
  • MoNA: VF-NPL-QEHF013308
  • MoNA: VF-NPL-QTOF007268
  • MoNA: VF-NPL-QTOF007269
  • MoNA: VF-NPL-QTOF007270
  • MoNA: VF-NPL-QTOF007271
  • MoNA: VF-NPL-QTOF007272
  • MoNA: VF-NPL-QTOF007273
  • MoNA: VF-NPL-QTOF007274
  • MoNA: VF-NPL-QTOF007275
  • MoNA: VF-NPL-QTOF007276
  • MoNA: VF-NPL-QTOF007277
  • MoNA: VF-NPL-QTOF007278
  • MoNA: VF-NPL-QTOF007279
  • Metlin: METLIN_43572
  • Coconut NaturalProduct: CNP0190002.0
  • Coconut NaturalProduct: CNP0199599.0
  • Coconut NaturalProduct: CNP0213051.0

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R06554 C09762<=>C10208
KEGG:R06564 2.1.1.46 S-adenosyl-L-methionine:daidzein 4'-O-methyltransferase
KEGG:R06606 1.14.14.90 daidzein,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2'-hydroxylating)
KEGG:R07317 4.2.1.105 2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
KEGG:R07720 2.4.1.170 UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase
KEGG:R07724 2.1.1.150 S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase
KEGG:R07725 C10208<=>C10200
KEGG:R13051 3.2.1.21 daidzein 7-O-glucoside glucohydrolase
KEGG:R13053 C10524<=>C10208 + C22562
KEGG:R13054 1.3.1.- C10208 + C00005 + C00080<=>C22556 + C00006
BioCyc:RXN-3542 2.1.1.46 diadzein 4'-O-methyltransferase
BioCyc:RXN-4501 1.14.14.90 DAIDZEIN + Red-NADPH-Hemoprotein-Reductases + OXYGEN-MOLECULE --> 2-HYDROXYDAIDZEIN + Ox-NADPH-Hemoprotein-Reductases + WATER
BioCyc:RXN-11640 1.3.1.- DAIDZEIN + NADPH + PROTON --> CPD-24413 + NADP
BioCyc:RXN-3481 2.1.1.150 S-ADENOSYLMETHIONINE + DAIDZEIN --> PROTON + CPD-3343 + ADENOSYL-HOMO-CYS
BioCyc:RXN-3584 2.4.1.170 CPD-12575 + DAIDZEIN --> PROTON + CPD-3424 + UDP
BioCyc:RXN-3284 4.2.1.105 2-HYDROXYISOFLAVANONE --> DAIDZEIN + WATER
BioCyc:RXN-3591 3.2.1.- CPD-3424 + WATER --> DAIDZEIN + Glucopyranose
View More
Organism Source

Taxonomy Source

  1. Aaptos ciliata [ncbi taxid: ]
  2. Abies excelsa [ncbi taxid: ]
  3. Abies pinsapo var. marocana [ncbi taxid: 928731]
  4. Achlya heterosexualis [ncbi taxid: 112030]
  5. Aeschrion excelsa [ncbi taxid: ]
  6. aged korean fermented soybean paste [ncbi taxid: ]
  7. Albizia procera [ncbi taxid: 384949]
  8. Alternaria macrospora [ncbi taxid: 119921]
  9. Amorphinopsis foetida [ncbi taxid: 555053]
  10. Ampelocera edentula [ncbi taxid: 1568982]
  11. Angelica acutiloba [ncbi taxid: 55605]
  12. Arachis hypogaea [ncbi taxid: 3818]
  13. Arnica mollis [ncbi taxid: 4247]
  14. Arum maximum [ncbi taxid: ]
  15. Ascochyta viciae [ncbi taxid: 1677696]
  16. Asterias rathbuni [ncbi taxid: ]
  17. Astragalus membranaceus [ncbi taxid: 649199]
  18. Astragalus mongholicus [ncbi taxid: 119829]
  19. Astragalus wiedemannianus [ncbi taxid: ]
  20. Baphicacanthus cusia [ncbi taxid: ]
  21. Bertya dimerostigma [ncbi taxid: ]
  22. Botrytis cinerea [ncbi taxid: 40559]
  23. Brachymeris montana [ncbi taxid: ]
  24. Brassica carinata [ncbi taxid: 52824]
  25. Brazilian Red Propolis [ncbi taxid: ]
  26. Bryocaulon pseudosatoanum [ncbi taxid: 1709429]
  27. Bryonia alba [ncbi taxid: 243967]
  28. Cacospongia scalaris [ncbi taxid: ]
  29. Cajanus cajan [ncbi taxid: 3821]
  30. Calicotome villosa [ncbi taxid: 49799]
  31. Camellia sinensis [ncbi taxid: 4442]
  32. Candida albicans [ncbi taxid: 5476]
  33. Carpha glomerata [ncbi taxid: 224675]
  34. Caulis millettiae [ncbi taxid: ]
  35. Caulis spatholobi [ncbi taxid: ]
  36. Chamomilla recutita [ncbi taxid: ]
  37. Chrysosporum ovalisporum [ncbi taxid: ]
  38. Cistanche salsa [ncbi taxid: 161396]
  39. Coniochaeta saccardoi [ncbi taxid: ]
  40. Cordyceps sinensis [ncbi taxid: ]
  41. Crotalaria assamica [ncbi taxid: 671522]
  42. Crotalaria pallida [ncbi taxid: 3830]
  43. Croton gratissimus [ncbi taxid: 316784]
  44. Croton megistocarpus [ncbi taxid: 425923]
  45. Croton zehntneri [ncbi taxid: ]
  46. Cullen corylifolium [ncbi taxid: 429560]
  47. Cyanostegia angustifolia [ncbi taxid: 664348]
  48. Dactylorhiza viridis [ncbi taxid: 230577]
  49. Dalbergia frutescens [ncbi taxid: 450026]
  50. Dalbergia obtusa [ncbi taxid: 2805526]
  51. Dalbergia odorifera [ncbi taxid: 499988]
  52. Davidsoniella virescens [ncbi taxid: 1580837]
  53. Delphinium barbeyi [ncbi taxid: 136316]
  54. Diplopterygium glaucum [ncbi taxid: 397682]
  55. Dorstenia dinklagei [ncbi taxid: 2604986]
  56. Epimedium brevicornu [ncbi taxid: 253618]
  57. Epimedium grandiflorum [ncbi taxid: 244027]
  58. Epimedium koreanum [ncbi taxid: 63351]
  59. Epimedium pubescens [ncbi taxid: 153729]
  60. Epimedium sagittatum [ncbi taxid: 253616]
  61. Epimedium sempervirens [ncbi taxid: 253615]
  62. Epimedium wushanense [ncbi taxid: 253611]
  63. Eriocephalus punctulatus [ncbi taxid: ]
  64. Eucalyptus resinifera [ncbi taxid: 1711506]
  65. Euphrasia genargentea [ncbi taxid: ]
  66. Eurycoma harmandiana [ncbi taxid: ]
  67. Fomes fastuosus [ncbi taxid: ]
  68. Garcinia oblongifolia [ncbi taxid: 1009475]
  69. Geranium sibiricum [ncbi taxid: 345237]
  70. Glycine max [ncbi taxid: 3847]
  71. Glycine max (L.) Merr. [ncbi taxid: ]
  72. Glycine soja [ncbi taxid: 3848]
  73. Glycyrrhiza uralensis [ncbi taxid: 74613]
  74. Halobacillus litoralis [ncbi taxid: 45668]
  75. Heliotropium hirsutissimum [ncbi taxid: 168347]
  76. Hericium erinaceum [ncbi taxid: ]
  77. Homo sapiens [ncbi taxid: 9606]
  78. Inulanthera calva [ncbi taxid: 127985]
  79. Ipomoea muricata [ncbi taxid: 231710]
  80. Ips cembrae [ncbi taxid: 55982]
  81. Ixeris debilis [ncbi taxid: ]
  82. Junceella gemmacea [ncbi taxid: ]
  83. Lagerstroemia indica [ncbi taxid: 141186]
  84. Lecanora kukunorensis [ncbi taxid: ]
  85. Leguminosae [ncbi taxid: ]
  86. Lentinus tigrinus [ncbi taxid: 5365]
  87. Lippia integrifolia [ncbi taxid: 925356]
  88. Lobophytum durum [ncbi taxid: ]
  89. Lysimachia fordiana [ncbi taxid: 213266]
  90. Marasmiellus troyanus [ncbi taxid: ]
  91. Maximowiczia sonorae [ncbi taxid: ]
  92. Maytenus chuchuhuasha [ncbi taxid: ]
  93. Medicago sativa [ncbi taxid: 3879]
  94. Melaleuca viminea [ncbi taxid: 73768]
  95. Melia azedarach [ncbi taxid: 155640]
  96. Melia azedarach var. toosendan [ncbi taxid: 71608]
  97. Mirabilis jalapa [ncbi taxid: 3538]
  98. Mitracarpus scaber [ncbi taxid: ]
  99. Munchausia speciosa [ncbi taxid: ]
  100. Murraya exotica [ncbi taxid: 2901850]
  101. Murraya paniculata [ncbi taxid: 43711]
  102. Neomeris annulata [ncbi taxid: ]
  103. Neurymenia fraxinifolia [ncbi taxid: 89212]
  104. Nicotiana raimondii [ncbi taxid: 200312]
  105. Ophiorrhiza kunstleri [ncbi taxid: ]
  106. Orthosiphon spicatus [ncbi taxid: ]
  107. Oxytropis falcata [ncbi taxid: 1479707]
  108. Penstemon teucrioides [ncbi taxid: 388213]
  109. Persea kusanoi [ncbi taxid: ]
  110. Phaseolus vulgaris [ncbi taxid: 3885]
  111. phoma glomerata [ncbi taxid: ]
  112. Pinus koraiensis [ncbi taxid: 88728]
  113. Piper wightii [ncbi taxid: 1508052]
  114. Piptanthus nepalensis [ncbi taxid: 70606]
  115. Pisolithus tinctorius [ncbi taxid: 37468]
  116. Pongamia pinnata [ncbi taxid: 56065]
  117. Pterolobium hexapetalum [ncbi taxid: 1905003]
  118. Pueraria lobata [ncbi taxid: ]
  119. Pueraria lobata (Willd.) Ohwi [ncbi taxid: ]
  120. Pueraria montana var. lobata [ncbi taxid: 3893]
  121. Pueraria montana var. thomsonii [ncbi taxid: 174648]
  122. Pueraria peduncularis [ncbi taxid: ]
  123. Pueraria phaseoloides [ncbi taxid: ]
  124. Ranunculus asiaticus [ncbi taxid: 529701]
  125. Remirea maritima [ncbi taxid: ]
  126. Sapium haematospermum [ncbi taxid: 316852]
  127. Schizophyllum lobatum [ncbi taxid: ]
  128. Scolopia chinensis [ncbi taxid: 1603833]
  129. Senecio isatideus [ncbi taxid: ]
  130. Setosphaeria holmii [ncbi taxid: ]
  131. Sinapis alba [ncbi taxid: 3728]
  132. Sisymbrium officinale [ncbi taxid: 203582]
  133. Solanum lanceolatum [ncbi taxid: 329782]
  134. Sophora japonica [ncbi taxid: ]
  135. Sophora subprostrata [ncbi taxid: ]
  136. Sophora tonkinensis [ncbi taxid: 714503]
  137. Spatholobus suberectus [ncbi taxid: 455371]
  138. Stachys chrysantha [ncbi taxid: 193336]
  139. Streptomyces cavourensis YBQ59 [ncbi taxid: ]
  140. Streptomyces DGC1 [ncbi taxid: ]
  141. Streptomyces filamentosus [ncbi taxid: 67294]
  142. Streptomyces globisporus 1912 [ncbi taxid: ]
  143. Streptomyces matensis [ncbi taxid: 67325]
  144. Streptomyces mirabilis [ncbi taxid: 68239]
  145. Streptomyces olivaceus Tü 4018 [ncbi taxid: ]
  146. Streptomyces sp. AC35 [ncbi taxid: 555738]
  147. Streptomyces sp. RB1 [ncbi taxid: 1855955]
  148. Streptomyces sp. SS52 [ncbi taxid: 2563602]
  149. Streptomyces sp. TPU1401A [ncbi taxid: ]
  150. Streptomyces xanthophaeus [ncbi taxid: 67385]
  151. Streptomyces xanthophaeus MD865-C3 [ncbi taxid: ]
  152. Streptomyces YIM 65408 [ncbi taxid: ]
  153. Tabebuia chrysantha [ncbi taxid: ]
  154. Tephrosia elata [ncbi taxid: ]
  155. Teucrium betonicum [ncbi taxid: 1209843]
  156. Trididemnum cyanophorum [ncbi taxid: 1079458]
  157. Trifolium pratense [ncbi taxid: 57577]
  158. Trifolium pratense L. [ncbi taxid: ]
  159. Trifolium repens [ncbi taxid: 3899]
  160. Trifolium repens L. [ncbi taxid: ]
  161. Trifolium resupinatum [ncbi taxid: 97036]
  162. Trigonella foenum-graecum [ncbi taxid: 78534]
  163. Trollius europaeus [ncbi taxid: 212754]
  164. Viburnum erubescens [ncbi taxid: 237938]
  165. Wikstroemia viridiflora [ncbi taxid: ]
  166. Xanthorhiza simplicissima [ncbi taxid: 13762]
  167. Zanthoxylum decaryi [ncbi taxid: 3411585]
  168. Thermobifida alba [ncbi taxid: 53522]
  169. Thermomonospora alba [ncbi taxid: ]
  170. Dalbergia odorifera [ncbi taxid: 499988]
  171. Dalbergia parviflora [ncbi taxid: 1353466]
  172. Leguminosae [ncbi taxid: ]

Pathway Synthetic

pathway id name
BioCyc:META_PWY-2343 daidzein conjugates interconversion
BioCyc:META_PWY-6996 daidzin and daidzein degradation
BioCyc:META_PWY-2229 superpathway of pterocarpan biosynthesis (via formononetin)
BioCyc:META_PWY-2002 isoflavonoid biosynthesis I
BioCyc:META_PWY-2761 (-)-glycinol biosynthesis
BioCyc:META_PWY-6332 coumestrol biosynthesis
BioCyc:META_PWY-2055 superpathway of pterocarpan biosynthesis (via daidzein)
BioCyc:META_PWY-2321 formononetin biosynthesis
Plant Reactome:R-OSA-2744345 Metabolism and regulation
Plant Reactome:R-OSA-2744344 Secondary metabolism
Plant Reactome:R-OSA-1119398 Pterocarpan biosynthesis
PlantCyc:CARIETINUM_ICC4958_PWY-2002 isoflavonoid biosynthesis I
PlantCyc:CARIETINUM_ICC4958_PWY-2321 formononetin biosynthesis
PlantCyc:COMMONBEAN_PWY-2321 formononetin biosynthesis
PlantCyc:COMMONBEAN_PWY-2761 (-)-glycinol biosynthesis
PlantCyc:LJAPONICUS_PWY-2321 formononetin biosynthesis
PlantCyc:STORA_PWY-2002 isoflavonoid biosynthesis I
PlantCyc:PLANT_PWY-6332 coumestrol biosynthesis
PlantCyc:PLANT_PWY-2321 formononetin biosynthesis
PlantCyc:REDCLOVER_PWY-2002 isoflavonoid biosynthesis I
View All Pathways