Metabolite Card
Formula: C6H13O9P (260.0297)
SMILES: O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O
Synonyms [en]
D-Mannose 6-phosphate; alpha-D-mannose-6-P; mannose-6-phosphate; D-mannopyranose 6-phosphate; Mannose 6-phosphate; Man-6-p
Last reviewed on 2024-06-28.
Cite this Page
D-Mannose 6-phosphate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000009407). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
Mannose 6-phosphate, also known as alpha-D-mannose-6-p or man-6-p, belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. Mannose 6-phosphate exists in all eukaryotes, ranging from yeast to humans. Within humans, mannose 6-phosphate participates in a number of enzymatic reactions. In particular, mannose 6-phosphate can be converted into fructose 6-phosphate through its interaction with the enzyme mannose-6-phosphate isomerase. In addition, mannose 6-phosphate can be biosynthesized from D-mannose through the action of the enzyme hexokinase-1. Mannose 6-phosphate is a potent competitive inhibitor of pinocytosis of human platelet beta-glucuronidase and it is a necessary component of the recognition marker on the enzyme for pinocytosis by human fibroblasts as well (PMID 908752). In humans, mannose 6-phosphate is involved in fructose intolerance, hereditary.
DBLinks
- CAS Registry Number: 3672-15-9
- PubChem CID: 439198
- ChEBI: 17369
- HMDB: HMDB0001078
- LipidMaps:
- KEGG: C00275
- BioCyc:
- NCBI MeSH: mannose-6-phosphate
- Wikipedia: Mannose 6-phosphate
Other DBLinks
- CAS Registry Number: 104872-94-8
- CAS Registry Number: 3672-15-9
- CAS Registry Number: 40436-58-6
- CAS Registry Number: 40436-61-1
- CAS Registry Number: 723729-16-6
- CAS Registry Number: NA
- PubChem: 439198
- PubChem: 65127
- ChEBI: ChEBI:17369
- ChEBI: ChEBI:48066
- ChEBI: ChEBI:49728
- HMDB: HMDB0001078
- HMDB: HMDB01078
- HMDB: HMDB0304312
- KEGG: C00275
- NCBI MeSH: mannose-6-phosphate
- Wikipedia: Mannose 6-phosphate
- Wikipedia: Mannose_6-phosphate
- RefMet: RM0157550
- MoNA: BAF_UVA_POS000461
- MoNA: BAF_UVA_POS000462
- MoNA: BAF_UVA_POS000463
- MoNA: BAF_UVA_POS000464
- MoNA: BAF_UVA_POS001376
- MoNA: BAF_UVA_POS001377
- MoNA: BAF_UVA_POS001378
- MoNA: CCMSLIB00005464423
- MoNA: CCMSLIB00005720717
- MoNA: EMBL-MCF_spec119996
- MoNA: EMBL-MCF_spec119997
- MoNA: EMBL-MCF_spec48515
- MoNA: EMBL_MCF_2_0_HRMS_Library000246
- MoNA: HMDB0001078_ms_ms_1418
- MoNA: HMDB0001078_ms_ms_1419
- MoNA: HMDB0001078_ms_ms_1420
- MoNA: KO001324
- MoNA: KO001325
- MoNA: KO001326
- MoNA: KO001327
- MoNA: MoNA024049
- MoNA: MoNA024081
- MoNA: MoNA032060
- MoNA: MoNA032061
- MoNA: MoNA032062
- MoNA: MoNA034000
- MoNA: MoNA034002
- MoNA: MoNA034003
- MoNA: MoNA037154
- MoNA: MoNA037863
- MoNA: PR100335
- MoNA: PR100551
- MoNA: PR100776
- MoNA: PS022101
- MoNA: PS022107
- MoNA: PS022108
- MoNA: PS022109
- MoNA: PS022110
- MoNA: PS022111
- MoNA: PS022112
- MoNA: PS078501
- MoNA: PS078507
- MoNA: PS078508
- MoNA: PS078509
- MoNA: PS078510
- Metlin: METLIN_5987
- Coconut NaturalProduct: CNP0209092.3
- Coconut NaturalProduct: CNP0209092.5
Class / Ontology
- WishartLab ClassyFire: [Carbohydrates and carbohydrate conjugates] Carbohydrates and carbohydrate conjugates
- RefMet: [Hexose phosphates] Hexose phosphates
- ChEBI: [CHEBI:17369] D-mannose 6-phosphate
- ChEBI: [CHEBI:48066] D-mannopyranose 6-phosphate
- Coconut NaturalProduct: [Monosaccharides] Monosaccharides
| ID | EC Number | Name |
|---|---|---|
| KEGG:R00772 | 5.3.1.8 | D-mannose-6-phosphate aldose-ketose-isomerase |
| KEGG:R01326 | 2.7.1.1 | ATP:D-mannose 6-phosphotransferase |
| KEGG:R01327 | 2.7.1.1 | ITP:D-mannose 6-phosphotransferase |
| KEGG:R01330 | 2.7.1.1 | dATP:D-mannose 6-phosphotransferase |
| KEGG:R01817 | 1.1.1.224 | D-mannitol-1-phosphate:NADP+ 6-oxidoreductase |
| KEGG:R01818 | 5.4.2.8 | D-mannose 6-phosphate 1,6-phosphomutase |
| KEGG:R01819 | 5.3.1.8 | D-mannose-6-phosphate aldose-ketose-isomerase |
| KEGG:R02630 | 2.7.1.191 | protein-N(pi)-phosphohistidine:D-mannose 6-phosphotransferase |
| KEGG:R08405 | 2.7.1.61 | acyl-phosphate:D-mannose phosphotransferase |
| KEGG:R09645 | 3.2.1.- | C16699 + C00001<=>C00275 + C00258 |
| KEGG:R11439 | 2.5.1.132 | phosphoenolpyruvate:D-mannose-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase |
| KEGG:R13490 | 4.2.3.230 | D-mannose-6-phosphate phosphate-lyase (2-deoxy-4-epi-scyllo-inosose-forming) |
Taxonomy Source
Pathway Synthetic
| pathway id | name |
|---|---|
| PathBank:SMP0002108 | 2-O-alpha-Mannosyl-D-glycerate Degradation |
| WikiPathways:WP5153 | N-glycan biosynthesis |
| WikiPathways:WP3604 | Biochemical pathways: part I |
| PathBank:SMP0120625 | Fructosuria |
| PathBank:SMP0000064 | Fructose and Mannose Degradation |
| PathBank:SMP0002331 | Amino Sugar and Nucleotide Sugar Metabolism |
| PathBank:SMP0087197 | Fructose and Mannose Degradation |
| PathBank:SMP0120657 | Fructose Intolerance, Hereditary |
| PathBank:SMP0000725 | Fructose Intolerance, Hereditary |
| PathBank:SMP0012444 | Mannose Metabolism |
| PathBank:SMP0120844 | Fructosuria |
| PathBank:SMP0120876 | Fructose Intolerance, Hereditary |
| PathBank:SMP0000561 | Fructosuria |
| PathBank:SMP0087296 | Fructose and Mannose Degradation |
| PathBank:SMP0063614 | Fructose and Mannose Degradation |
| PathBank:SMP0002315 | Mannose Metabolism |