Cortisone (BioCAD00000008906)
blood saliva urine adipose tissue adrenal cortex adrenal gland epidermis fibroblasts intestine kidney neuron placenta skeletal muscle testis thyroid gland plant natural products
Metabolite Card
Formula: C21H28O5 (360.1937)
SMILES: [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Synonyms [en]
cortisone; Reichstein's substance FA; Kendall's compound E; Wintersteiner's compound F; Cortison; Kortison
Reviewed
Last reviewed on 2024-06-28.
Cite this Page
Cortisone. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000008906). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
Cortisone is a naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver into the active metabolite cortisol. Cortisone is a corticosteroid hormone released by the adrenal gland in response to stress. One of cortisone's effects on the body, and a potentially harmful side effect when administered clinically, is the suppression of the immune system. This is an explanation for the apparent correlation between high stress and sickness.
Entity Information
DBLinks
- CAS Registry Number: 53-06-5
- PubChem CID: 222786
- ChEBI: 16962
- HMDB: HMDB0002802
- LipidMaps: LMST02030090
- KEGG: C00762
- BioCyc: CORTISONE
- NCBI MeSH: Cortisone
- Wikipedia: Cortisone
Other DBLinks
- CAS Registry Number: 17736-16-2
- CAS Registry Number: 53-06-5
- CAS Registry Number: ?53-06-5
- PubChem: 222786
- PubChem: 56625892
- PubChem: 6708812
- ChEBI: ChEBI:16962
- HMDB: HMDB0002802
- LipidMaps: LMST02030090
- KEGG: C00762
- BioCyc: CORTISONE
- NCBI MeSH: Cortisone
- Wikipedia: Cortisone
- DrugBank: DB14681
- RefMet: RM0128363
- MoNA: AU239301
- MoNA: AU239302
- MoNA: AU239303
- MoNA: AU239304
- MoNA: AU239305
- MoNA: AU239306
- MoNA: AU239357
- MoNA: AU239358
- MoNA: AU239359
- MoNA: AU239360
- MoNA: BAF_UVA_POS000550
- MoNA: BAF_UVA_POS000551
- MoNA: BAF_UVA_POS000552
- MoNA: CB000366
- MoNA: CCMSLIB00000077194
- MoNA: CCMSLIB00005463901
- MoNA: CCMSLIB00005463902
- MoNA: CCMSLIB00005463903
- MoNA: CCMSLIB00005720592
- MoNA: CCMSLIB00005720898
- MoNA: EQ319901
- MoNA: EQ319902
- MoNA: EQ319903
- MoNA: EQ319904
- MoNA: EQ319905
- MoNA: EQ319906
- MoNA: EQ319907
- MoNA: EQ319908
- MoNA: EQ319909
- MoNA: EQ319951
- MoNA: EQ319952
- MoNA: EQ319953
- MoNA: EQ319954
- MoNA: EQ319955
- MoNA: EQ319956
- MoNA: EQ319957
- MoNA: EQ319958
- MoNA: EQ319959
- MoNA: FiehnHILIC000277
- MoNA: FiehnHILIC001130
- MoNA: FiehnHILIC001850
- MoNA: FiehnHILIC002650
- MoNA: FiehnLib001002
- MoNA: HMDB0002802_c_ms_99784
- MoNA: HMDB0002802_ms_ms_2134
- MoNA: HMDB0002802_ms_ms_2135
- MoNA: HMDB0002802_ms_ms_2136
- MoNA: LU112001
- MoNA: LU112002
- MoNA: LU112003
- MoNA: LU112004
- MoNA: LU112006
- MoNA: LU112051
- MoNA: LU112052
- MoNA: LU112053
- MoNA: LU112054
- MoNA: LU112055
- MoNA: LU112056
- MoNA: MoNA016677
- MoNA: MoNA016855
- MoNA: MoNA032561
- MoNA: MoNA032566
- MoNA: MoNA032567
- MoNA: MoNA034692
- MoNA: MoNA034695
- MoNA: MoNA034699
- MoNA: MoNA036396
- MoNA: MoNA036397
- MoNA: MoNA036401
- MoNA: MoNA037355
- MoNA: MoNA038106
- MoNA: MoNA038691
- MoNA: NA000001
- MoNA: NA000002
- MoNA: NA000003
- MoNA: NA000004
- MoNA: NA000005
- MoNA: NA000006
- MoNA: NA000007
- MoNA: NA000008
- MoNA: NA000009
- MoNA: NA000010
- MoNA: NA000011
- MoNA: NA000012
- MoNA: NA000013
- MoNA: NA000014
- MoNA: NA000015
- MoNA: NA000016
- MoNA: NA000017
- MoNA: NA000018
- MoNA: NA000019
- MoNA: NA000020
- MoNA: NA000021
- MoNA: NA000022
- MoNA: NA000023
- MoNA: NA000024
- MoNA: NA000025
- MoNA: NGA00753
- MoNA: NGA00754
- MoNA: NGA00755
- MoNA: NGA00756
- MoNA: UF415401
- MoNA: UF415402
- MoNA: UF415403
- MoNA: UF415404
- MoNA: UF415701
- MoNA: UF415702
- MoNA: UF415703
- MoNA: UF415704
- MoNA: UF423101
- MoNA: UF423102
- MoNA: UF423103
- MoNA: UF423104
- MoNA: VF-NPL-LTQ000254
- MoNA: VF-NPL-LTQ007121
- MoNA: VF-NPL-LTQ007122
- MoNA: VF-NPL-LTQ007123
- MoNA: VF-NPL-LTQ007124
- MoNA: VF-NPL-QEHF000526
- MoNA: VF-NPL-QEHF000527
- MoNA: VF-NPL-QEHF000528
- MoNA: VF-NPL-QEHF000529
- MoNA: VF-NPL-QEHF000530
- MoNA: VF-NPL-QEHF000531
- MoNA: VF-NPL-QEHF013894
- MoNA: VF-NPL-QEHF013895
- MoNA: VF-NPL-QEHF013896
- MoNA: VF-NPL-QEHF013897
- MoNA: VF-NPL-QEHF013898
- MoNA: VF-NPL-QEHF013899
- MoNA: VF-NPL-QTOF007147
- MoNA: VF-NPL-QTOF007148
- MoNA: VF-NPL-QTOF007149
- MoNA: VF-NPL-QTOF007150
- MoNA: VF-NPL-QTOF007151
- MoNA: VF-NPL-QTOF007152
- MoNA: VF-NPL-QTOF007153
- MoNA: VF-NPL-QTOF007154
- MoNA: VF-NPL-QTOF007155
- MoNA: VF-NPL-QTOF007156
- MoNA: VF-NPL-QTOF007157
- MoNA: VF-NPL-QTOF007158
- MoNA: WA000374
- MoNA: WA000375
- MoNA: WA000376
- MoNA: WA000377
- MoNA: WA000378
- MoNA: WA000385
- MoNA: WA000386
- MoNA: WA000387
- MoNA: WA000388
- MoNA: WA000389
- MoNA: WA000390
- Metlin: METLIN_271
- Coconut NaturalProduct: CNP0233309.2
- Coconut NaturalProduct: CNP0233309.3
- Coconut NaturalProduct: CNP0233309.6
- Coconut NaturalProduct: CNP0321174.1
- Coconut NaturalProduct: CNP0585917.0
Class / Ontology
- WishartLab ClassyFire: [Hydroxysteroids] Hydroxysteroids
- RefMet: [C21 steroids] C21 steroids
- LipidMaps: [C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives [ST0203]] C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives [ST0203]
- ChEBI: [CHEBI:16962] cortisone
- Coconut NaturalProduct: [Pregnane steroids] Pregnane steroids
- Coconut NaturalProduct: [Meroterpenoids] Meroterpenoids
Metabolic Network
| ID | EC Number | Name |
|---|---|---|
| KEGG:R02834 | 1.1.1.- | cortisol:NAD+ 11-oxidoreductase |
| KEGG:R02836 | 1.1.1.146 | cortisol:NADP+ 11-oxidoreductase |
| KEGG:R02892 | 1.3.1.22 | 4,5alpha-dihydrocortisone:NADP+ delta4-oxidoreductase |
| KEGG:R02893 | 1.3.1.3 | 17alpha,21-dihydroxy-5beta-pregnane-3,11,20-trione:NADP+ delta4-oxidoreductase |
| Rhea:RHEA:14038 | 1.3.1.3 | 4,5β-dihydrocortisone + NADP+ => cortisone + NADPH + H+ |
| Rhea:RHEA:14039 | 1.3.1.3 | cortisone + NADPH + H+ => 4,5β-dihydrocortisone + NADP+ |
| Rhea:RHEA:14040 | 1.3.1.3 | 4,5β-dihydrocortisone + NADP+ <=> cortisone + NADPH + H+ |
| Rhea:RHEA:42017 | cortisone + NAD+ => 17α-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H+ | |
| Rhea:RHEA:42018 | 17α-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H+ => cortisone + NAD+ | |
| Rhea:RHEA:42019 | cortisone + NAD+ <=> 17α-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H+ | |
| Rhea:RHEA:50209 | cortisol + NAD+ => cortisone + NADH + H+ | |
| Rhea:RHEA:50210 | cortisone + NADH + H+ => cortisol + NAD+ | |
| Rhea:RHEA:50211 | cortisol + NAD+ <=> cortisone + NADH + H+ | |
| Rhea:RHEA:55833 | cortisone + reduced [NADPH—hemoprotein reductase] + O2 => 6β-hydroxycortisone + oxidized [NADPH—hemoprotein reductase] + H2O + H+ | |
| Rhea:RHEA:55834 | 6β-hydroxycortisone + oxidized [NADPH—hemoprotein reductase] + H2O + H+ => cortisone + reduced [NADPH—hemoprotein reductase] + O2 | |
| Rhea:RHEA:55835 | cortisone + reduced [NADPH—hemoprotein reductase] + O2 <=> 6β-hydroxycortisone + oxidized [NADPH—hemoprotein reductase] + H2O + H+ | |
| Rhea:RHEA:68617 | cortisone + NADPH + H+ => cortisol + NADP+ | |
| Rhea:RHEA:68618 | cortisol + NADP+ => cortisone + NADPH + H+ | |
| Rhea:RHEA:68619 | cortisone + NADPH + H+ <=> cortisol + NADP+ | |
| Rhea:RHEA:68621 | cortisone + NADPH + H+ => 20β-dihydrocortisone + NADP+ |
Mass Spectrum
Organism Source
Taxonomy Source
- Homo sapiens [ncbi taxid: 9606]
- Mus musculus [ncbi taxid: 10090]
- Phytolacca acinosa [ncbi taxid: 3528]
Pathway Synthetic
| pathway id | name |
|---|---|
| Reactome:R-SPO-194002 | Glucocorticoid biosynthesis |
| Reactome:R-BTA-1430728 | Metabolism |
| Reactome:R-BTA-556833 | Metabolism of lipids |
| Reactome:R-BTA-194002 | Glucocorticoid biosynthesis |
| Reactome:R-CFA-1430728 | Metabolism |
| Reactome:R-CFA-556833 | Metabolism of lipids |
| Reactome:R-CFA-194002 | Glucocorticoid biosynthesis |
| Reactome:R-DRE-196071 | Metabolism of steroid hormones |
| Reactome:R-DME-194002 | Glucocorticoid biosynthesis |
| Reactome:R-GGA-194002 | Glucocorticoid biosynthesis |
| Reactome:R-HSA-194002 | Glucocorticoid biosynthesis |
| Reactome:R-MMU-1430728 | Metabolism |
| Reactome:R-MMU-556833 | Metabolism of lipids |
| Reactome:R-MMU-8957322 | Metabolism of steroids |
| Reactome:R-RNO-196071 | Metabolism of steroid hormones |
| Reactome:R-SPO-1430728 | Metabolism |
| Reactome:R-SSC-196071 | Metabolism of steroid hormones |
| Reactome:R-XTR-194002 | Glucocorticoid biosynthesis |
| Reactome:R-BTA-8957322 | Metabolism of steroids |
| Reactome:R-CFA-8957322 | Metabolism of steroids |