Corticosterone (BioCAD00000008899)
blood urine adipose tissue adrenal cortex adrenal gland brain epidermis fibroblasts intestine kidney liver neuron ovary placenta platelet spleen testis plant natural products
Metabolite Card
Formula: C21H30O4 (346.2144)
SMILES: [H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@]([H])(O)C[C@]12C)C(=O)CO
Synonyms [en]
Corticosterone; Kendall's compound B; Reichstein's substance H; 17-Deoxycortisol; 11beta,21-Dihydroxy-4-pregnene-3,20-dione; 11beta,21-Dihydroxyprogesterone
Last reviewed on 2024-06-28.
Cite this Page
Corticosterone. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000008899). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
Corticosterone, also known as 17-deoxycortisol, belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. Thus, corticosterone is considered to be a steroid lipid molecule. Corticosterone is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. In many species, including amphibians, reptiles, rodents and birds, corticosterone is a main glucocorticoid,[3] involved in regulation of energy, immune reactions, and stress responses. Corticosterone is the precursor molecule to the mineralocorticoid aldosterone, one of the major homeostatic modulators of sodium and potassium levels in vivo.
DBLinks
- CAS Registry Number: 50-22-6
- PubChem CID: 5753
- ChEBI: 16827
- HMDB: HMDB0001547
- LipidMaps: LMST02030186
- KEGG: C02140
- BioCyc: CORTICOSTERONE
- NCBI MeSH: Corticosterone
- Wikipedia: Corticosterone
Other DBLinks
- CAS Registry Number: 50-22-6
- CAS Registry Number: 600-70-4
- PubChem: 5753
- ChEBI: ChEBI:16827
- HMDB: HMDB0001547
- HMDB: HMDB01547
- LipidMaps: LMST02030186
- KEGG: C02140
- BioCyc: CORTICOSTERONE
- NCBI MeSH: Corticosterone
- Wikipedia: Corticosterone
- DrugBank: DB04652
- RefMet: RM0126032
- MoNA: AU218301
- MoNA: AU218302
- MoNA: AU218303
- MoNA: AU218304
- MoNA: AU218305
- MoNA: BAF_UVA_POS000664
- MoNA: BAF_UVA_POS000665
- MoNA: BAF_UVA_POS001328
- MoNA: CCMSLIB00005463890
- MoNA: CCMSLIB00005463891
- MoNA: CCMSLIB00005463892
- MoNA: CCMSLIB00005463893
- MoNA: CCMSLIB00005463894
- MoNA: CCMSLIB00005463895
- MoNA: CCMSLIB00005720593
- MoNA: EQ319801
- MoNA: EQ319802
- MoNA: EQ319803
- MoNA: EQ319804
- MoNA: EQ319805
- MoNA: EQ319806
- MoNA: EQ319807
- MoNA: EQ319808
- MoNA: EQ319809
- MoNA: FiehnHILIC000275
- MoNA: FiehnHILIC001849
- MoNA: HMDB0001547_c_ms_2274
- MoNA: HMDB0001547_c_ms_2276
- MoNA: HMDB0001547_ms_ms_1646
- MoNA: HMDB0001547_ms_ms_1647
- MoNA: HMDB0001547_ms_ms_1648
- MoNA: JP009695
- MoNA: LU131101
- MoNA: LU131102
- MoNA: LU131103
- MoNA: LU131105
- MoNA: LU131106
- MoNA: MoNA016599
- MoNA: MoNA016676
- MoNA: MoNA016851
- MoNA: MoNA032506
- MoNA: MoNA032507
- MoNA: MoNA032511
- MoNA: MoNA034617
- MoNA: MoNA034618
- MoNA: MoNA034623
- MoNA: MoNA036349
- MoNA: MoNA036351
- MoNA: MoNA036354
- MoNA: MoNA037331
- MoNA: MoNA038079
- MoNA: MoNA038674
- MoNA: VF-NPL-LTQ000425
- MoNA: VF-NPL-LTQ000426
- MoNA: WA001124
- MoNA: WA001125
- MoNA: WA001126
- MoNA: WA001127
- MoNA: WA001128
- Metlin: METLIN_41868
- Metlin: METLIN_6314
- Coconut NaturalProduct: CNP0221293.2
- Coconut NaturalProduct: CNP0377638.1
Class / Ontology
- WishartLab ClassyFire: [Hydroxysteroids] Hydroxysteroids
- RefMet: [C21 steroids] C21 steroids
- LipidMaps: [C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives [ST0203]] C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives [ST0203]
- ChEBI: [CHEBI:16827] corticosterone
- Coconut NaturalProduct: [Pregnane steroids] Pregnane steroids
| ID | EC Number | Name |
|---|---|---|
| KEGG:R03262 | 1.14.15.4 | corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating) |
| KEGG:R03847 | 1.1.1.- | corticosterone:NAD+ 11-oxidoreductase |
| KEGG:R03848 | 1.1.1.146 | corticosterone:NADP+ 11-oxidoreductase |
| KEGG:R03849 | 1.14.14.16 | 11beta-hydroxyprogesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating) |
| KEGG:R03850 | 1.3.1.3 | 11beta,21-dihydroxy-5beta-pregnane-3,20-dione:NADP+ 4,5-oxidoreductase |
| KEGG:R03851 | 1.14.15.4 | 11-deoxycorticosterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating) |
| Rhea:RHEA:11873 | 1.14.15.5 | corticosterone + 2 reduced [adrenodoxin] + O2 + 2 H+ => 18-hydroxycorticosterone + 2 oxidized [adrenodoxin] + H2O |
| Rhea:RHEA:11874 | 1.14.15.5 | 18-hydroxycorticosterone + 2 oxidized [adrenodoxin] + H2O => corticosterone + 2 reduced [adrenodoxin] + O2 + 2 H+ |
| Rhea:RHEA:11875 | 1.14.15.5 | corticosterone + 2 reduced [adrenodoxin] + O2 + 2 H+ <=> 18-hydroxycorticosterone + 2 oxidized [adrenodoxin] + H2O |
| Rhea:RHEA:42201 | corticosterone + NADP+ => 11-dehydrocorticosterone + NADPH + H+ | |
| Rhea:RHEA:42202 | 11-dehydrocorticosterone + NADPH + H+ => corticosterone + NADP+ | |
| Rhea:RHEA:42203 | corticosterone + NADP+ <=> 11-dehydrocorticosterone + NADPH + H+ | |
| Rhea:RHEA:42205 | corticosterone + NAD+ => 11-dehydrocorticosterone + NADH + H+ | |
| Rhea:RHEA:42206 | 11-dehydrocorticosterone + NADH + H+ => corticosterone + NAD+ | |
| Rhea:RHEA:42207 | corticosterone + NAD+ <=> 11-dehydrocorticosterone + NADH + H+ | |
| Rhea:RHEA:46105 | 21-hydroxyprogesterone + 2 reduced [adrenodoxin] + O2 + 2 H+ => corticosterone + 2 oxidized [adrenodoxin] + H2O | |
| Rhea:RHEA:46106 | corticosterone + 2 oxidized [adrenodoxin] + H2O => 21-hydroxyprogesterone + 2 reduced [adrenodoxin] + O2 + 2 H+ | |
| Rhea:RHEA:46107 | 21-hydroxyprogesterone + 2 reduced [adrenodoxin] + O2 + 2 H+ <=> corticosterone + 2 oxidized [adrenodoxin] + H2O | |
| Rhea:RHEA:46665 | corticosterone + NADPH + H+ => 5β-dihydrocorticosterone + NADP+ | |
| Rhea:RHEA:46666 | 5β-dihydrocorticosterone + NADP+ => corticosterone + NADPH + H+ |
Taxonomy Source
- Homo sapiens [ncbi taxid: 9606]
- Hypericum monogynum [ncbi taxid: 684760]
- Mus musculus [ncbi taxid: 10090]
Pathway Synthetic
| pathway id | name |
|---|---|
| Reactome:R-BTA-1430728 | Metabolism |
| Reactome:R-BTA-556833 | Metabolism of lipids |
| Reactome:R-BTA-211945 | Phase I - Functionalization of compounds |
| Reactome:R-CFA-1430728 | Metabolism |
| Reactome:R-CFA-556833 | Metabolism of lipids |
| Reactome:R-CFA-211976 | Endogenous sterols |
| Reactome:R-HSA-211859 | Biological oxidations |
| Reactome:R-HSA-1643685 | Disease |
| Reactome:R-MMU-1430728 | Metabolism |
| Reactome:R-MMU-556833 | Metabolism of lipids |
| Reactome:R-MMU-8957322 | Metabolism of steroids |
| Reactome:R-MMU-211859 | Biological oxidations |
| Reactome:R-RNO-196071 | Metabolism of steroid hormones |
| Reactome:R-RNO-211945 | Phase I - Functionalization of compounds |
| Reactome:R-SSC-196071 | Metabolism of steroid hormones |
| Reactome:R-SSC-211945 | Phase I - Functionalization of compounds |
| Reactome:R-XTR-211897 | Cytochrome P450 - arranged by substrate type |
| Reactome:R-BTA-8957322 | Metabolism of steroids |
| Reactome:R-BTA-211859 | Biological oxidations |
| Reactome:R-CFA-8957322 | Metabolism of steroids |