8(S)-HPETE (BioCAD00000005590)

{$topic}

Metabolite Card

Formula: C20H32O4 (336.23)
SMILES: CCCCC\C=C/C\C=C/C=C/[C@H](C\C=C/CCCC(O)=O)OO

Synonyms [en]

8(S)-HPETE; 8S-HpETE; (5Z,9E,11Z,14Z)-(8S)-8-Hydroperoxyeicosa-5,9,11,14-tetraenoic acid; 8S-hydoperoxy-5Z,9E,11Z,14Z-eicosatetraenoic acid; (5Z,9E,11Z,14Z)-(8S)-8-Hydroperoxyicosa-5,9,11,14-tetraenoic acid; 8-HPETE

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

8(S)-HPETE. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000005590). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

8S-HPETE is metabolized from arachidonic acid by the enzyme 8S-lipoxygenase (8-LOX in mouse, ALOX15 and ALOX15B in human). 8S-HPETE will be readily reduced under physiological circumstances to 8S-hydroxyeicosatetraenoic acid (8S-HETE), a natural agonist of peroxisome proliferator-activated receptor alpha (PPAR alpha). (PMID: 16112079).

Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 100896-35-3
  • PubChem: 6438881
  • PubChem: 9548880
  • ChEBI: ChEBI:34487
  • HMDB: HMDB0004699
  • LipidMaps: LMFA03060073
  • KEGG: C14823
  • NCBI MeSH: 8-hydroperoxyeicosatetraenoic acid
  • RefMet: RM0073555
  • Metlin: METLIN_36325
  • Coconut NaturalProduct: CNP0085037.2
  • Coconut NaturalProduct: CNP0085037.3

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R07053 1.13.11.- arachidonate:oxygen 8-oxidoreductase
View More
Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
WikiPathways:WP4721 Eicosanoid metabolism via lipooxygenases (LOX)
WikiPathways:WP4348 Eicosanoid metabolism via lipoxygenases (LOX)
PathBank:SMP0120730 Leukotriene C4 Synthesis Deficiency
PathBank:SMP0000083 Acetylsalicylic Acid Action Pathway
PathBank:SMP0000087 Rofecoxib Action Pathway
PathBank:SMP0000094 Sulindac Action Pathway
PathBank:SMP0000104 Indomethacin Action Pathway
PathBank:SMP0000120 Naproxen Action Pathway
PathBank:SMP0000106 Meloxicam Action Pathway
PathBank:SMP0000693 Antrafenine Action Pathway
PathBank:SMP0000697 Flurbiprofen Action Pathway
PathBank:SMP0000701 Phenylbutazone Action Pathway
PathBank:SMP0000705 Tiaprofenic Acid Action Pathway
PathBank:SMP0000709 Salicylic Acid Action Pathway
PathBank:SMP0000075 Arachidonic Acid Metabolism
PathBank:SMP0000086 Ibuprofen Action Pathway
PathBank:SMP0000093 Diclofenac Action Pathway
PathBank:SMP0000098 Ketorolac Action Pathway
PathBank:SMP0000102 Bromfenac Action Pathway
PathBank:SMP0000114 Nabumetone Action Pathway
View All Pathways