6-Phospho-D-gluconate (BioCAD00000005266)

blood cellular cytoplasm saliva adipose tissue epidermis fibroblasts placenta prostate

Metabolite Card

Formula: C6H13O10P (276.0246)
SMILES: O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O

Synonyms [en]

6-phospho-D-gluconate; 6-phosphogluconic acid; 6-phospho-D-gluconic acid; 6-PHOSPHOGLUCONATE; 6-p-Gluconate; D-Gluconic acid 6-(dihydrogen phosphate)

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

6-Phospho-D-gluconate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000005266). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

6-Phosphogluconic acid, also known as 6-phospho-D-gluconate or gluconic acid-6-phosphate, belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphated group linked to the carbohydrate unit. 6-Phosphogluconic acid exists in all living species, ranging from bacteria to humans. Within humans, 6-phosphogluconic acid participates in a number of enzymatic reactions. In particular, 6-phosphogluconic acid can be biosynthesized from gluconolactone; which is mediated by the enzyme 6-phosphogluconolactonase. In addition, 6-phosphogluconic acid can be converted into D-ribulose 5-phosphate through the action of the enzyme 6-phosphogluconate dehydrogenase, decarboxylating. In humans, 6-phosphogluconic acid is involved in the metabolic disorder called the transaldolase deficiency pathway. Outside of the human body, 6-Phosphogluconic acid has been detected, but not quantified in several different foods, such as cascade huckleberries, common chokecherries, half-highbush blueberries, american cranberries, and okra.

Endoplasmic reticulum
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 53411-70-4
  • CAS Registry Number: 921-62-0
  • PubChem: 3638
  • PubChem: 91493
  • ChEBI: ChEBI:16863
  • ChEBI: ChEBI:48928
  • HMDB: HMDB0001316
  • KEGG: C00345
  • BioCyc: CPD-2961
  • NCBI MeSH: 6-phosphogluconic acid
  • Wikipedia: 6-Phosphogluconic_acid
  • DrugBank: DB02076
  • RefMet: RM0155882
  • MoNA: BAF_UVA_POS000528
  • MoNA: BAF_UVA_POS001143
  • MoNA: BAF_UVA_POS001144
  • MoNA: CCMSLIB00000578211
  • MoNA: CCMSLIB00005464358
  • MoNA: CCMSLIB00005464487
  • MoNA: CCMSLIB00005720409
  • MoNA: CCMSLIB00005720709
  • MoNA: EMBL-MCF_spec118279
  • MoNA: EMBL-MCF_spec46735
  • MoNA: EMBL_MCF_2_0_HRMS_Library000269
  • MoNA: HMDB0001316_c_ms_1921
  • MoNA: HMDB0001316_c_ms_1967
  • MoNA: HMDB0001316_ms_ms_1516
  • MoNA: HMDB0001316_ms_ms_1517
  • MoNA: HMDB0001316_ms_ms_1518
  • MoNA: KNA00748
  • MoNA: KNA00749
  • MoNA: KNA00750
  • MoNA: KNA00751
  • MoNA: KO001600
  • MoNA: KO001601
  • MoNA: KO001602
  • MoNA: KO001603
  • MoNA: KO001604
  • MoNA: MoNA024147
  • MoNA: MoNA024179
  • MoNA: MoNA033956
  • MoNA: MoNA033960
  • MoNA: MoNA033961
  • MoNA: MoNA037847
  • MoNA: PS003807
  • Metlin: METLIN_367
  • Coconut NaturalProduct: CNP0360081.1
  • Coconut NaturalProduct: CNP0360081.2

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R01528 1.1.1.44 6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
KEGG:R01737 2.7.1.12 ATP:D-gluconate 6-phosphotransferase
KEGG:R02032 1.1.1.43 6-phospho-2-dehydro-D-gluconate:NAD+ 2-oxidoreductase
KEGG:R02034 1.1.1.43 6-phospho-D-gluconate:NADP+ 2-oxidoreductase
KEGG:R02035 3.1.1.31 6-phospho-D-glucono-1,5-lactone lactonohydrolase
KEGG:R02036 4.2.1.12 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)
KEGG:R10221 1.1.1.343 6-phospho-D-gluconate:NAD+ 2-oxidoreductase (decarboxylating)
BioCyc:GLUCONOKIN-RXN 2.7.1.12 ATP + GLUCONATE --> PROTON + CPD-2961 + ADP
BioCyc:PGLUCONDEHYDRAT-RXN 4.2.1.12 CPD-2961 --> 2-KETO-3-DEOXY-6-P-GLUCONATE + WATER
BioCyc:6PGLUCONOLACT-RXN 3.1.1.31 D-6-P-GLUCONO-DELTA-LACTONE + WATER --> PROTON + CPD-2961
BioCyc:RXN0-5185 3.1.3.- CPD-2961 + WATER --> GLUCONATE + Pi
BioCyc:RXN-9952 1.1.1.44 CPD-2961 + NADP --> RIBULOSE-5P + CARBON-DIOXIDE + NADPH
BioCyc:1.1.1.43-RXN 1.1.1.43 CPD-339 + NADH-P-OR-NOP + PROTON --> CPD-2961 + NAD-P-OR-NOP
BioCyc:RXN-3341 1.1.1.343 CPD-2961 + NAD --> RIBULOSE-5P + CARBON-DIOXIDE + NADH
BioCyc:6PGLUCONDEHYDROG-RXN 1.1.1.351 phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
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Organism Source

Taxonomy Source

  1. Arabidopsis thaliana [ncbi taxid: 3702]
  2. Escherichia coli [ncbi taxid: 562]

Pathway Synthetic

pathway id name
BioCyc:LEISH_PWY3IU-99 superpathway of central carbon metabolism
BioCyc:TRYPANO_GLUCONSUPER-PWY D-gluconate degradation
BioCyc:LEISH_OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch)
BioCyc:TRYPANO_IDNCAT-PWY L-idonate degradation
BioCyc:TRYPANO_RUMP-PWY formaldehyde oxidation I
BioCyc:TRYPANO_GLYCOLYSIS-E-D superpathway of glycolysis and Entner-Doudoroff
BioCyc:TRYPANO_P122-PWY heterolactic fermentation
BioCyc:TRYPANO_OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch)
BioCyc:LEISH_PENTOSE-P-PWY pentose phosphate pathway
BioCyc:TRYPANO_ENTNER-DOUDOROFF-PWY Entner-Doudoroff pathway I
BioCyc:TRYPANO_PENTOSE-P-PWY pentose phosphate pathway
WikiPathways:WP3583 Central carbon metabolism
WikiPathways:WP282 Pentose phosphate pathway
WikiPathways:WP134 Pentose phosphate metabolism
WikiPathways:WP1946 Cori cycle
WikiPathways:WP3604 Biochemical pathways: part I
WikiPathways:WP5043 Pentose phosphate pathway in senescent cells
WikiPathways:WP63 Pentose phosphate pathway
WikiPathways:WP3602 Metabolism overview
WikiPathways:WP2562 Relationship between glutathione and NADPH
View All Pathways