6-Acetamido-2-oxohexanoate (BioCAD00000005121)

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Metabolite Card

Formula: C8H13NO4 (187.0845)
SMILES: CC(=O)NCCCCC(=O)C(O)=O

Synonyms [en]

2-oxo-6-Acetamidocaproate; 2-Keto-6-acetamidohexanoic acid; 6-acetamido-2-Oxohexanoic acid; 2-Keto-6-acetamidocaproate; 2-oxo-6-Acetamidocaproic acid; 2-Keto-6-acetamidocaproic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

6-Acetamido-2-oxohexanoate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000005121). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

2-Keto-6-acetamidocaproate is an intermediate in lysine degradation. It can be generated from N6-acetyl-L-lysine. N-acetyl-lysine is an acetylated amino acid. Post-translational lysine-acetylation is one of two major modifications of lysine residues in various proteins. Acetylation of specific lysine residues in the N-terminal domains of core histones is a biochemical marker of active genes. Acetylation is now known to play a major role in eukaryotic transcription. Specifically, acetyltransferase enzymes that act on particular lysine side chains of histones and other proteins are intimately involved in transcriptional activation. N6-acetyl-L-lysine can be converted to 2-Keto-6-acetamidocaproate via the enzyme N6-acetyllysine aminotransferase and then 2-keto-6-acetamidocaproate can be reduced enzymatically to 5-acetamidovalerate.

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 59403-50-8
  • PubChem: 194080
  • ChEBI: ChEBI:28376
  • HMDB: HMDB0012150
  • HMDB: HMDB12150
  • KEGG: C05548
  • BioCyc: 2-KETO-6-ACETAMIDOCAPROATE
  • NCBI MeSH: 3-keto-6-acetamidohexanoate
  • RefMet: RM0118181
  • Metlin: METLIN_62815
  • Coconut NaturalProduct: CNP0373135.0

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R04029 2.6.1.65 N6-acetyl-L-lysine:2-oxoglutarate aminotransferase
KEGG:R04142 1.2.4.- C03087 + C00004 + C00080 + C00011<=>C05548 + C00003 + C00001
KEGG:R04174 3.5.1.17 6-acetamido-2-oxohexanoate amidohydrolase
BioCyc:ACETCAPR-RXN 2.6.1.- CPD-567 + 2-KETOGLUTARATE<=>GLT + 2-KETO-6-ACETAMIDOCAPROATE
BioCyc:KETAMID-RXN 1.1.1.- WATER + 2-KETO-6-ACETAMIDOCAPROATE + NAD --> PROTON + 5-ACETAMIDOVALERATE + NADH + CARBON-DIOXIDE
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
WikiPathways:WP3604 Biochemical pathways: part I
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