5(S)-HETE (BioCAD00000005042)

blood cerebrospinal fluid (csf) placenta

Metabolite Card

Formula: C20H32O3 (320.2351)
SMILES: CCCCC\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCCC(O)=O

Synonyms [en]

5(S)-HETE; 5-Hete; 5-Hydroxyeicosatetraenoate; 5S-HETE; (6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid; (5S,6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

5(S)-HETE. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000005042). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

5-hydroxyeicosatetraenoic acid (5-HETE) is an endogenous eicosanoid. 5-HETE is an intermediate in arachidonic acid metabolism. It is converted from 5(S)-HPETE via the enzyme glutathione peroxidase (EC 1.11.1.9)and then converted to 5-OxoETE. It is also involved in the pathway of leukotriene synthesis. In addition, it is a modulator of tubuloglomerular feedback.

Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 330796-62-8
  • CAS Registry Number: 70608-72-9
  • CAS Registry Number: 71030-39-2
  • CAS Registry Number: 72255-35-7
  • CAS Registry Number: 73307-52-5
  • PubChem: 1771
  • PubChem: 5280733
  • PubChem: 5283165
  • PubChem: 5353348
  • PubChem: 9862886
  • ChEBI: ChEBI:165284
  • ChEBI: ChEBI:28209
  • ChEBI: ChEBI:60943
  • HMDB: HMDB0011134
  • HMDB: HMDB02218
  • HMDB: HMDB11134
  • LipidMaps: LMFA03060002
  • LipidMaps: LMFA03060024
  • LipidMaps: LMFA03060084
  • KEGG: C04805
  • NCBI MeSH: 5-hydroxy-6,8,11,14-eicosatetraenoic acid
  • Wikipedia: 5-Hydroxyeicosatetraenoic_acid
  • RefMet: RM0150780
  • RefMet: RM0152610
  • RefMet: RM0158210
  • MoNA: IA000076
  • MoNA: IA000077
  • MoNA: IA000078
  • MoNA: IA000250
  • MoNA: IA000251
  • MoNA: IA000252
  • MoNA: IA000388
  • MoNA: IA000389
  • MoNA: IA000390
  • MoNA: UT000172
  • MoNA: UT000173
  • MoNA: UT000174
  • MoNA: UT000175
  • MoNA: UT000176
  • MoNA: UT000177
  • MoNA: UT000178
  • MoNA: UT000179
  • MoNA: UT000180
  • Metlin: METLIN_36336
  • Metlin: METLIN_45684
  • Coconut NaturalProduct: CNP0115304.1

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R07034 1.11.1.12 glutathione: 5-HPETE oxidoreductase
KEGG:R13040 1.1.1.- C04805 + C00006<=>C14732 + C00005 + C00080
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Organism Source

Taxonomy Source

  1. Homo sapiens [ncbi taxid: 9606]
  2. Mus musculus [ncbi taxid: 10090]

Pathway Synthetic

pathway id name
WikiPathways:WP1311 Folic acid network
WikiPathways:WP1272 Selenium micronutrient network
WikiPathways:WP15 Selenium micronutrient network
WikiPathways:WP1310 Selenium micronutrient network
WikiPathways:WP5155 Arachidonic acid (AA, ARA) oxylipin metabolism
WikiPathways:WP1273 Folic acid network
WikiPathways:WP3257 Selenium micronutrient network
WikiPathways:WP167 Eicosanoid synthesis
PathBank:SMP0120730 Leukotriene C4 Synthesis Deficiency
PathBank:SMP0000083 Acetylsalicylic Acid Action Pathway
PathBank:SMP0000087 Rofecoxib Action Pathway
PathBank:SMP0000094 Sulindac Action Pathway
PathBank:SMP0000104 Indomethacin Action Pathway
PathBank:SMP0000120 Naproxen Action Pathway
PathBank:SMP0000106 Meloxicam Action Pathway
PathBank:SMP0000693 Antrafenine Action Pathway
PathBank:SMP0000697 Flurbiprofen Action Pathway
PathBank:SMP0000701 Phenylbutazone Action Pathway
PathBank:SMP0000705 Tiaprofenic Acid Action Pathway
PathBank:SMP0000709 Salicylic Acid Action Pathway
View All Pathways