Hypothiocyanite (BioCAD00000025504)

{$topic}

Metabolite Card

Formula: CHNOS (74.9779)
SMILES: OSC#N

Synonyms [en]

Hypothiocyanite; Cyanosulfoxylic acid; hypothiocyanous acid; Hypocyanous acid; (hydroxysulfanyl)formonitrile; Nitrilomethane-SO-thioperoxol

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Hypothiocyanite. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000025504). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

As it is an organic compound, hypothiocyanite occurs naturally in the antimicrobial immune system of the human respiratory tract in a redox reaction catalyzed by the enzyme lactoperoxidase. It has been researched extensively for its capabilities as an alternative antibiotic as it is harmless to human body cells while being cytotoxic to bacteria. Of late, the exact processes for making hypothiocyanite have been patented as such an effective antimicrobial has many commercial applications. Whether or not this antimicrobial compound comprises the entirety of the immune system of the respiratory tract remains to be seen. Hypothiocyanite is the anion [OSCN]- and the conjugate base of hypothiocyanous acid. It is an organic compound part of the thiocyanates as it contains the functional group SCN. It is formed when an oxygen is singly bonded to the thiocyanate group. Hypothiocyanous acid (HOSCN) is a fairly weak acid as its acid dissociation constant is 5.3.

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 63296-34-4
  • CAS Registry Number: 64253-39-0
  • PubChem: 124985
  • ChEBI: ChEBI:133907
  • HMDB: HMDB0012974
  • BioCyc: CPD-26678
  • NCBI MeSH: hypothiocyanite ion
  • Wikipedia: Hypothiocyanite
  • Coconut NaturalProduct: CNP0569271.0

Class / Ontology

Metabolic Network
ID EC Number Name
BioCyc:RXN-24132 1.6.99.- hypothiocyanous acid reductase
Rhea:RHEA:69417 thiocyanate + H2O2 + H+ => hypothiocyanous acid + H2O
Rhea:RHEA:69418 hypothiocyanous acid + H2O => thiocyanate + H2O2 + H+
Rhea:RHEA:69419 thiocyanate + H2O2 + H+ <=> hypothiocyanous acid + H2O
View More
Organism Source

Taxonomy Source

  1. Homo sapiens [ncbi taxid: 9606]
  2. Rattus norvegicus [ncbi taxid: 10116]

Pathway Synthetic

pathway id name
Reactome:R-GGA-8941413 Events associated with phagocytolytic activity of PMN cells
Reactome:R-DDI-8941413 Events associated with phagocytolytic activity of PMN cells
Reactome:R-CEL-8941413 Events associated with phagocytolytic activity of PMN cells
Reactome:R-SSC-8941413 Events associated with phagocytolytic activity of PMN cells
Reactome:R-RNO-8941413 Events associated with phagocytolytic activity of PMN cells
Reactome:R-CFA-8941413 Events associated with phagocytolytic activity of PMN cells
Reactome:R-DME-8941413 Events associated with phagocytolytic activity of PMN cells
Reactome:R-MMU-8941413 Events associated with phagocytolytic activity of PMN cells
Reactome:R-HSA-8941413 Events associated with phagocytolytic activity of PMN cells
Reactome:R-XTR-8941413 Events associated with phagocytolytic activity of PMN cells
Reactome:R-BTA-8941413 Events associated with phagocytolytic activity of PMN cells
Reactome:R-BTA-168256 Immune System
Reactome:R-DDI-168256 Immune System
Reactome:R-DDI-1222556 ROS and RNS production in phagocytes
Reactome:R-DME-168256 Immune System
Reactome:R-MMU-168256 Immune System
Reactome:R-MMU-168249 Innate Immune System
Reactome:R-SSC-168256 Immune System
Reactome:R-XTR-168249 Innate Immune System
Reactome:R-BTA-168249 Innate Immune System
View All Pathways