17-HETE (BioCAD00000025431)

blood

Metabolite Card

Formula: C20H32O3 (320.2351)
SMILES: CCCC(O)C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

Synonyms [en]

17-HETE; 17-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid; (all-cis)-17-Hydroxy-5,8,11,14-eicosatetraenoic acid; (all-cis)-17-Hydroxy-5,8,11,14-icosatetraenoic acid; 17-hydroxyarachidonic acid; (5Z,8Z,11Z,14Z)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

17-HETE. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000025431). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 ¬µM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive.

Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 128914-47-6
  • PubChem: 6442740
  • ChEBI: ChEBI:63995
  • HMDB: HMDB0012598
  • LipidMaps: LMFA03060091
  • RefMet: RM0150735
  • Metlin: METLIN_75020
  • Coconut NaturalProduct: CNP0049536.0

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

  1. Homo sapiens [ncbi taxid: 9606]

Pathway Synthetic

pathway id name
WikiPathways:WP4720 Eicosanoid metabolism via cytochrome P450 monooxygenases pathway
WikiPathways:WP5155 Arachidonic acid (AA, ARA) oxylipin metabolism
WikiPathways:WP4349 Eicosanoid metabolism via cytochrome P450 monooxygenases
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