2-Methylhippuric acid (BioCAD00000024806)

blood urine

Metabolite Card

Formula: C10H11NO3 (193.0739)
SMILES: CC1=C(C=CC=C1)C(=O)NCC(O)=O

Synonyms [en]

2-methylhippuric acid; N-(2-Methylbenzoyl)glycine; o-Toluric acid; o-methylhippuric acid; ortho-methylhippuric acid; N-(o-Toluoyl)glycine

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

2-Methylhippuric acid. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000024806). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

2-Methylhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases, the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine <--> CoA + N-acylglycine. 2-Methylhippuric acid is a metabolite of xylene which is an aromatic hydrocarbon widely used as a solvant. Its level can be measured in the urine of workers exposed to xylene (PMID:8689499). 2-Methylhippuric acid is an endogenous phenolic acid metabolite detected after the consumption of whole grain.

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 42013-20-7
  • PubChem: 91637
  • ChEBI: ChEBI:68455
  • HMDB: HMDB0011723
  • KEGG: C01586
  • NCBI MeSH: 2-methylhippuric acid
  • Wikipedia: Methylhippuric acid
  • RefMet: RM0136358
  • MoNA: GLS00079
  • MoNA: GLS00080
  • MoNA: HMDB0011723_c_ms_99972
  • MoNA: HMDB0011723_c_ms_99973
  • MoNA: HMDB0011723_c_ms_99974
  • MoNA: HMDB0011723_c_ms_99975
  • MoNA: HMDB0011723_c_ms_99976
  • MoNA: JP002236
  • MoNA: MoNA033172
  • MoNA: MoNA033173
  • MoNA: MoNA033177
  • MoNA: MoNA035357
  • MoNA: MoNA035358
  • MoNA: MoNA035359
  • MoNA: MoNA037536
  • MoNA: MoNA038288
  • Metlin: METLIN_24085
  • Coconut NaturalProduct: CNP0079825.0

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

  1. Homo sapiens [ncbi taxid: 9606]

Pathway Synthetic

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