1D-myo-Inositol 1,4,5,6-tetrakisphosphate (BioCAD00000002198)

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Metabolite Card

Formula: C6H16O18P4 (499.9287)
SMILES: O[C@H]1[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O

Synonyms [en]

1D-myo-Inositol 1,4,5,6-tetrakisphosphate; D-myo-Inositol 1,4,5,6-tetrakisphosphate; Inositol 1,4,5,6-tetrakisphosphate; {[(1S,2R,3S,4R,5R,6S)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid; 1D-myo-inositol 1,4,5,6-tetrakis(dihydrogen phosphate); 6-triphosphonooxycyclohexyl dihydrogen phosphate

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

1D-myo-Inositol 1,4,5,6-tetrakisphosphate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000002198). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Inositol phosphates are a family of water-soluble intracellular signalling molecules derived from membrane inositol phospholipids. They undergo a variety of complex interconversion pathways, and their levels are dynamically regulated within the cytosol in response to a variety of agonists. Their biological actions can be quite specific to particular inositol phosphates. D-myo-Inositol 3,4,5,6-tetrakisphosphate, also known as Ins(1,4,5,6)P4 is phosphorylated by inositolphosphate-multikinase (IMPK). Ins(1,4,5,6)P4 has been shown to regulate Cl- transport, to be a phosphoinositide 3-kinase antagonist, and to bind tightly to some pleckstrin homology domains. It may also contribute to transcriptional regulation (PMID: 16376887, 10720331, 8809047, 9405634).

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 109837-24-3
  • CAS Registry Number: 121010-58-0
  • CAS Registry Number: NA
  • PubChem: 443266
  • ChEBI: ChEBI:16067
  • HMDB: HMDB0004527
  • KEGG: C11555
  • NCBI MeSH: inositol-1,4,5,6-tetrakisphosphate
  • Metlin: METLIN_45090
  • Coconut NaturalProduct: CNP0044726.1
  • Coconut NaturalProduct: CNP0044726.2
  • Coconut NaturalProduct: CNP0290577.3

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R05800 2.7.1.151 ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase
KEGG:R05801 2.7.1.151 ATP:1D-myo-inositol-1,4,5,6-tetrakisphosphate 3-phosphotransferase
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Organism Source

Taxonomy Source

  1. Mus musculus [ncbi taxid: 10090]

Pathway Synthetic

pathway id name
PathBank:SMP0002397 Inositol Metabolism
PathBank:SMP0087242 Inositol Metabolism
PathBank:SMP0063630 Inositol Phosphate Metabolism
PathBank:SMP0000011 Inositol Metabolism
PathBank:SMP0000462 Inositol Phosphate Metabolism
PathBank:SMP0002394 Inositol Phosphate Metabolism
PathBank:SMP0087349 Inositol Phosphate Metabolism
PathBank:SMP0063629 Inositol Metabolism
PathBank:SMP0087256 Inositol Phosphate Metabolism
PathBank:SMP0087396 Inositol Metabolism
PathBank:SMP0087408 Inositol Phosphate Metabolism
PathBank:SMP0087496 Inositol Phosphate Metabolism
PathBank:SMP0087335 Inositol Metabolism
PathBank:SMP0087459 Inositol Metabolism
View All Pathways