Yohimbine (BioCAD00000019507)
blood urine plant natural products microbial natural products
Metabolite Card
Formula: C21H26N2O3 (354.1943)
SMILES: [H][C@@]12CC[C@H](O)[C@H](C(=O)OC)[C@@]1([H])C[C@]1([H])N(CCC3=C1NC1=CC=CC=C31)C2
Synonyms [en]
Yohimbine; (+)-Yohimbine; APHRODINE; Johimbin; Corynine; Yohimbin
Last reviewed on 2024-06-28.
Cite this Page
Yohimbine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000019507). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
Yohimbine is only found in individuals that have used or taken this drug. It is a plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. [PubChem]Yohimbine is a pre-synaptic alpha 2-adrenergic blocking agent. The exact mechanism for its use in impotence has not been fully elucidated. However, yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei. Yohimbine-mediated norepinephrine release at the level of the corporeal tissues may also be involved. In addition, beneficial effects may involve other neurotransmitters such as dopamine and serotonin and cholinergic receptors.
DBLinks
- CAS Registry Number: 146-48-5
- PubChem CID: 8969
- ChEBI: 10093
- HMDB: HMDB0015464
- LipidMaps:
- KEGG: C09256
- BioCyc: CPD-21567
- NCBI MeSH: Yohimbine
- Wikipedia: Yohimbine
Other DBLinks
- CAS Registry Number: 103834-06-6
- CAS Registry Number: 112350-93-3
- CAS Registry Number: 1169-60-4
- CAS Registry Number: 131-03-3
- CAS Registry Number: 146-48-5
- CAS Registry Number: 182509-57-5
- CAS Registry Number: 37247-87-3
- CAS Registry Number: 483-10-3
- PubChem: 643606
- PubChem: 8969
- PubChem: 92766
- ChEBI: ChEBI:10093
- ChEBI: ChEBI:48562
- ChEBI: ChEBI:92122
- HMDB: HMDB0015464
- KEGG: C09256
- KEGG: D08685
- BioCyc: CPD-21567
- NCBI MeSH: Yohimbine
- Wikipedia: Corynanthine
- Wikipedia: Rauwolscine
- Wikipedia: Yohimbine
- DrugBank: DB01392
- RefMet: RM0204157
- MoNA: Alkaloids000049
- MoNA: CCMSLIB00000424794
- MoNA: CCMSLIB00004680087
- MoNA: NA002379
- MoNA: NA002380
- MoNA: NA002381
- MoNA: NA002382
- MoNA: NA002383
- MoNA: NA002774
- MoNA: NA002775
- MoNA: NA002776
- MoNA: NA002777
- MoNA: NA002778
- MoNA: NA003154
- MoNA: NA003155
- MoNA: NA003156
- MoNA: NA003157
- MoNA: NA003158
- MoNA: NA003519
- MoNA: NA003520
- MoNA: NA003521
- MoNA: NA003522
- MoNA: NA003523
- MoNA: PM005501
- MoNA: TOF_alkaloids_neg000018
- MoNA: TOF_alkaloids_neg000019
- MoNA: TOF_alkaloids_pos000039
- MoNA: TOF_alkaloids_pos000040
- MoNA: VF-NPL-QEHF011479
- MoNA: VF-NPL-QEHF011480
- MoNA: VF-NPL-QEHF011481
- MoNA: WA002417
- MoNA: WA002418
- MoNA: WA002419
- MoNA: WA002420
- MoNA: WA002421
- Metlin: METLIN_3043
- Metlin: METLIN_85115
- Coconut NaturalProduct: CNP0162441.3
- Coconut NaturalProduct: CNP0249975.0
- Coconut NaturalProduct: CNP0305326.1
- Coconut NaturalProduct: CNP0305326.12
- Coconut NaturalProduct: CNP0314383.1
- Coconut NaturalProduct: CNP0334582.0
- Coconut NaturalProduct: CNP0528441.0
- Coconut NaturalProduct: CNP0604632.0
Class / Ontology
- WishartLab ClassyFire: [Yohimbine alkaloids] Yohimbine alkaloids
- RefMet: [Yohimbine-like alkaloids] Yohimbine-like alkaloids
- ChEBI: [CHEBI:10093] yohimbine
- Coconut NaturalProduct: [Corynanthe type] Corynanthe type
- Coconut NaturalProduct: [Aspidosperma type] Aspidosperma type
- Coconut NaturalProduct: [Yohimbine-like alkaloids] Yohimbine-like alkaloids
- Coconut NaturalProduct: [Aporphine alkaloids] Aporphine alkaloids
- Coconut NaturalProduct: [Chromones] Chromones
Taxonomy Source
- Catharanthus roseus [ncbi taxid: 4058]
- Rhazya stricta [ncbi taxid: 396313]
- Corynanthe johimbe [ncbi taxid: 170026]
- Eremophila oppositifolia [ncbi taxid: 2652586]
- Haplophyton crooksii L.Benson [ncbi taxid: ]
- Homo sapiens [ncbi taxid: 9606]
- Pausinylstalia yohimbe [ncbi taxid: ]
- Pausinystalia macroceras [ncbi taxid: ]
- Pausinystalia paniculata [ncbi taxid: ]
- Pausinystalia yohimbe [ncbi taxid: ]
- Pausinystalia yomhinbe [ncbi taxid: ]
- Rauvolfia nitida [ncbi taxid: 947893]
- Rauvolfia serpentina [ncbi taxid: 4060]
- Rauvolfia vomitoria [ncbi taxid: 403115]
- Rauvolfia yunnanensis [ncbi taxid: 1217299]
- Rauwolfia serpentina [ncbi taxid: ]
- Sonchus erzincanicus [ncbi taxid: 2874835]
- Actinostemma lobatum [ncbi taxid: 1635145]
- Ardisia pusilla [ncbi taxid: 587403]
- Dendrobium lohohense [ncbi taxid: 161870]
- Excoecaria cochinchinensis [ncbi taxid: 179682]
- Glossocarya calcicola [ncbi taxid: ]
- Monochaetia dimorphospora [ncbi taxid: 1835169]
- Rosa gallica [ncbi taxid: 74632]
- Stenocarpus salignus [ncbi taxid: 83741]
- Stephanitis pyri [ncbi taxid: 1400073]
- Ulmus davidiana [ncbi taxid: 1297873]
- Aristolochia curcurbitifolia [ncbi taxid: ]
- Aristolochia manshuriensis [ncbi taxid: 158555]
- Aristolochia rotunda [ncbi taxid: 360044]
- Couepia polyandra [ncbi taxid: 1856781]
- Dysophylla verticillata [ncbi taxid: ]
- Lavandula hybrida [ncbi taxid: ]
- Spatoglossum schmittii [ncbi taxid: ]
Pathway Synthetic
| pathway id | name |
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