Uroporphyrinogen I (BioCAD00000019223)

testis

Metabolite Card

Formula: C40H44N4O16 (836.2752)
SMILES: OC(=O)CCC1=C2CC3=C(CC(O)=O)C(CCC(O)=O)=C(CC4=C(CC(O)=O)C(CCC(O)=O)=C(CC5=C(CC(O)=O)C(CCC(O)=O)=C(CC(N2)=C1CC(O)=O)N5)N4)N3

Synonyms [en]

Uroporphyrinogen I; uroporphyrinogen-I; uro'gen I; 3,8,13,18-tetrakis(carboxymethyl)-5,10,15,20,22,24-hexahydroporphyrin-2,7,12,17-tetrapropionic acid; 3,8,13,18-tetrakis(carboxymethyl)-5,10,15,20,22,24-hexahydroporphyrin-2,7,12,17-tetrapropanoic acid; 3-[9,14,19-tris(2-carboxyethyl)-5,10,15,20-tetrakis(carboxymethyl)-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1(20),3,5,8,10,13,15,18-octaen-4-yl]propanoic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Uroporphyrinogen I. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000019223). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Uroporphyrinogens are porphyrinogen variants in which each pyrrole ring has one acetate side chain and one propionate side chain; it is formed by condensation 4 four molecules of porphobilinogen. 4 isomers are possible but only 2 commoly are found, types I and III. Uroporphyrinogen III is a functional intermediate in heme biosynthesis while Uroporphyrinogen I is produced in an abortive side reaction.

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 1867-62-5
  • PubChem: 440775
  • ChEBI: ChEBI:28766
  • HMDB: HMDB0002211
  • HMDB: HMDB02211
  • KEGG: C05766
  • BioCyc: CPD-11444
  • Wikipedia: Uroporphyrinogen I
  • Metlin: METLIN_6550
  • Coconut NaturalProduct: CNP0083512.0

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R03166 C01024<=>C05766 + C00001
KEGG:R04971 C05766 + C00030<=>C05767 + C00028 + 6 C00080
KEGG:R04972 4.1.1.37 uroporphyrinogen I carboxy-lyase
BioCyc:RXN-14396 HYDROXYMETHYLBILANE --> CPD-11444 + WATER
BioCyc:RXN-10642 4.1.1.37 CPD-11444 + 4 PROTON --> COPROPORPHYRINOGEN_I + 4 CARBON-DIOXIDE
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Organism Source

Taxonomy Source

  1. Homo sapiens [ncbi taxid: 9606]
  2. Mus musculus [ncbi taxid: 10090]

Pathway Synthetic

pathway id name
PathBank:SMP0000953 Porphyrin Metabolism
WikiPathways:WP3604 Biochemical pathways: part I
WikiPathways:WP5169 Hemesynthesis defects and porphyrias
PathBank:SMP0120492 Hereditary Coproporphyria (HCP)
PathBank:SMP0120544 Porphyria Variegata (PV)
PathBank:SMP0000024 Porphyrin Metabolism
PathBank:SMP0120689 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease
PathBank:SMP0120447 Acute Intermittent Porphyria
PathBank:SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease
PathBank:SMP0087397 Porphyrin Metabolism
PathBank:SMP0063655 Porphyrin Metabolism
PathBank:SMP0120668 Acute Intermittent Porphyria
PathBank:SMP0120712 Hereditary Coproporphyria (HCP)
PathBank:SMP0120764 Porphyria Variegata (PV)
PathBank:SMP0120469 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease
PathBank:SMP0121321 Porphyrin Metabolism
PathBank:SMP0000344 Acute Intermittent Porphyria
PathBank:SMP0002363 Porphyrin Metabolism
PathBank:SMP0087336 Porphyrin Metabolism
PathBank:SMP0000346 Porphyria Variegata (PV)
View All Pathways