12-OxoETE (BioCAD00000001882)
Metabolite Card
Formula: C20H30O3 (318.2195)
SMILES: CCCCC\C=C/CC(=O)\C=C\C=C/C\C=C/CCCC(O)=O
Synonyms [en]
12-OxoETE; 12-oxo-ETE; 12-KETE; (5Z,8Z,10E,14Z)-12-Oxoeicosa-5,8,10,14-tetraenoic acid; (5Z,8Z,10E,14Z)-12-Oxoicosa-5,8,10,14-tetraenoic acid; 12-oxo-5Z,8Z,10E,14Z-eicosatetraenoic acid
Last reviewed on 2024-06-28.
Cite this Page
12-OxoETE. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000001882). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
12-keto-eicosatetraenoic acid is a biologically active eicosanoid in the nervous system of Aplysia.It is a metabolite of 12-HPETE formed by Aplysia nervous tissue. 12-KETE was identified in incubations of the tissue with arachidonic acid using HPLC, UV spectrometry, and gas-chromatography/mass spectrometry. [3H]12-KETE is formed from endogenous lipid stores in nervous tissue, labeled with [3H]arachidonic acid upon stimulation by application of histamine. In L14 and L10 cells, identified neurons in the abdominal ganglion, applications of 12-KETE elicit changes in membrane potential similar to those evoked by histamine.[PMID:2774398].
DBLinks
- CAS Registry Number: 108437-64-5
- PubChem CID: 5283162
- ChEBI: 34151
- HMDB: HMDB0013633
- LipidMaps: LMFA03060019
- KEGG: C14807
- BioCyc:
- NCBI MeSH: 12-keto-5,8,11,13-eicosatetraenoic acid
- Wikipedia:
Other DBLinks
- CAS Registry Number: 108437-64-5
- PubChem: 5283162
- ChEBI: ChEBI:34151
- HMDB: HMDB0013633
- LipidMaps: LMFA03060019
- KEGG: C14807
- NCBI MeSH: 12-keto-5,8,11,13-eicosatetraenoic acid
- RefMet: RM0153430
- MoNA: IA000163
- MoNA: IA000164
- MoNA: IA000165
- MoNA: IA000337
- MoNA: IA000338
- MoNA: IA000339
- MoNA: IA000415
- MoNA: IA000416
- MoNA: IA000417
- Metlin: METLIN_35314
- Metlin: METLIN_36285
- Coconut NaturalProduct: CNP0285442.0
Class / Ontology
- WishartLab ClassyFire: [Fatty acids and conjugates] Fatty acids and conjugates
- RefMet: [HETE] HETE
- LipidMaps: [Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]] Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
- ChEBI: [CHEBI:34151] 12-oxo-ETE
- Coconut NaturalProduct: [Hydroxy-hydroperoxyeicosatetraenoic acids] Hydroxy-hydroperoxyeicosatetraenoic acids
| ID | EC Number | Name |
|---|---|---|
| KEGG:R13044 | 4.2.1.152 | 12(R)-HPETE hydro-lyase |
| KEGG:R13045 | 4.2.1.152 | 12(S)-HPETE hydro-lyase |
Taxonomy Source
Pathway Synthetic
| pathway id | name |
|---|---|
| WikiPathways:WP4721 | Eicosanoid metabolism via lipooxygenases (LOX) |
| WikiPathways:WP5155 | Arachidonic acid (AA, ARA) oxylipin metabolism |
| WikiPathways:WP4348 | Eicosanoid metabolism via lipoxygenases (LOX) |
| PathBank:SMP0120730 | Leukotriene C4 Synthesis Deficiency |
| PathBank:SMP0000083 | Acetylsalicylic Acid Action Pathway |
| PathBank:SMP0000087 | Rofecoxib Action Pathway |
| PathBank:SMP0000094 | Sulindac Action Pathway |
| PathBank:SMP0000104 | Indomethacin Action Pathway |
| PathBank:SMP0000120 | Naproxen Action Pathway |
| PathBank:SMP0000106 | Meloxicam Action Pathway |
| PathBank:SMP0000693 | Antrafenine Action Pathway |
| PathBank:SMP0000697 | Flurbiprofen Action Pathway |
| PathBank:SMP0000701 | Phenylbutazone Action Pathway |
| PathBank:SMP0000705 | Tiaprofenic Acid Action Pathway |
| PathBank:SMP0000709 | Salicylic Acid Action Pathway |
| PathBank:SMP0000075 | Arachidonic Acid Metabolism |
| PathBank:SMP0000086 | Ibuprofen Action Pathway |
| PathBank:SMP0000093 | Diclofenac Action Pathway |
| PathBank:SMP0000098 | Ketorolac Action Pathway |
| PathBank:SMP0000102 | Bromfenac Action Pathway |