11,14,15-THETA (BioCAD00000001807)

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Metabolite Card

Formula: C20H34O5 (354.2406)
SMILES: CCCCCC(O)C(O)\C=C\C(O)C\C=C/C\C=C/CCCC(O)=O

Synonyms [en]

11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoic acid; 11,14,15-THETA; (5Z,8Z,12E)-11,14,15-trihydroxyicosa-5,8,12-trienoic acid; (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid; 11,14,15-Trihydroxyicosatrienoic acid; 11,14,15-trihydroxy-(5Z,8Z,12E)-eicosatrienoic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

11,14,15-THETA. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000001807). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

11,14,15-trihydroxyeicosatrienoic acid (11,14,15-THETA) is a metabolite of the 15-lipoxygenase (15-LO) pathway of arachidonic acid (AA). Increased amounts of 11,14,15-THETA are synthesized in subacute hypoxia. Prolonged exposure to reduced PO2 activates 15-LO in small pulmonary arteries (PA); activation of 15-LO is associated with translocation of the enzyme from the cytosol to membrane. 11,14,15-THETA is an endothelium-derived relaxing factor. (PMID: 12690037, 9812980, 15388505, 14622984).

Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 79595-81-6
  • PubChem: 11954059
  • PubChem: 6439531
  • ChEBI: ChEBI:34131
  • HMDB: HMDB0004694
  • HMDB: HMDB04694
  • LipidMaps: LMFA03050018
  • KEGG: C14814
  • NCBI MeSH: 11,14,15-trihydroxyeicosa-5,8,12-trienoic acid
  • Metlin: METLIN_36276

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R07045 1.14.14.1 C14813 + C00001<=>C14814
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
PathBank:SMP0120730 Leukotriene C4 Synthesis Deficiency
PathBank:SMP0000083 Acetylsalicylic Acid Action Pathway
PathBank:SMP0000087 Rofecoxib Action Pathway
PathBank:SMP0000094 Sulindac Action Pathway
PathBank:SMP0000104 Indomethacin Action Pathway
PathBank:SMP0000120 Naproxen Action Pathway
PathBank:SMP0000106 Meloxicam Action Pathway
PathBank:SMP0000693 Antrafenine Action Pathway
PathBank:SMP0000697 Flurbiprofen Action Pathway
PathBank:SMP0000701 Phenylbutazone Action Pathway
PathBank:SMP0000705 Tiaprofenic Acid Action Pathway
PathBank:SMP0000709 Salicylic Acid Action Pathway
PathBank:SMP0000075 Arachidonic Acid Metabolism
PathBank:SMP0000086 Ibuprofen Action Pathway
PathBank:SMP0000093 Diclofenac Action Pathway
PathBank:SMP0000098 Ketorolac Action Pathway
PathBank:SMP0000102 Bromfenac Action Pathway
PathBank:SMP0000114 Nabumetone Action Pathway
PathBank:SMP0000692 Antipyrine Action Pathway
PathBank:SMP0000696 Fenoprofen Action Pathway
View All Pathways