Nifedipine (BioCAD00000015194)
Metabolite Card
Formula: C17H18N2O6 (346.1165)
SMILES: COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1[N+]([O-])=O)C(=O)OC
Synonyms [en]
nifedipine; Nifedipres; Adapine; Adalat; Nifecard; Nifedipino
Last reviewed on 2024-06-28.
Cite this Page
Nifedipine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000015194). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nifedipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug's vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Nifedipine is used to treat hypertension and chronic stable angina.
DBLinks
- CAS Registry Number: 21829-25-4
- PubChem CID: 4485
- ChEBI: 7565
- HMDB: HMDB0015247
- LipidMaps:
- KEGG: C07266
- BioCyc: CPD-20503
- NCBI MeSH: Nifedipine
- Wikipedia: Nifedipine
Other DBLinks
- CAS Registry Number: 101539-70-2
- CAS Registry Number: 193689-82-6
- CAS Registry Number: 21829-25-4
- CAS Registry Number: 915092-63-6
- CAS Registry Number: Nifedipine - CAS 21829-25-4
- PubChem: 4485
- ChEBI: ChEBI:7565
- HMDB: HMDB0015247
- KEGG: C07266
- BioCyc: CPD-20503
- NCBI MeSH: Nifedipine
- Wikipedia: Nifedipine
- DrugBank: DB01115
- RefMet: RM0118019
- MoNA: CCMSLIB00000078299
- MoNA: FiehnHILIC000613
- MoNA: FiehnHILIC002180
- MoNA: MoNA033400
- MoNA: MoNA033402
- MoNA: MoNA033403
- MoNA: MoNA037626
- Metlin: METLIN_1535
- Coconut NaturalProduct: CNP0068780.0
- Coconut NaturalProduct: CNP0260111.1
- Coconut NaturalProduct: CNP0260111.2
- Coconut NaturalProduct: CNP0260111.3
- Coconut NaturalProduct: CNP0260111.4
- Coconut NaturalProduct: CNP0601416.0
Class / Ontology
- WishartLab ClassyFire: [Hydropyridines] Hydropyridines
- RefMet: [Dihydropyridine carboxylic acids] Dihydropyridine carboxylic acids
- ChEBI: [CHEBI:7565] nifedipine
Taxonomy Source
- Asarum heterotropoides [ncbi taxid: 366663]
- Asarum sieboldii [ncbi taxid: 76098]
- Asiasarum heterotropoides [ncbi taxid: ]
- Asiasarum sieboldii [ncbi taxid: ]
- Homo sapiens [ncbi taxid: 9606]
- Illigera luzonensis [ncbi taxid: 74946]
Pathway Synthetic
| pathway id | name |
|---|---|
| PathBank:SMP0000379 | Nifedipine Action Pathway |