N6-Methyl-L-lysine (BioCAD00000014957)
Metabolite Card
Formula: C7H16N2O2 (160.1212)
SMILES: CNCCCC[C@H](N)C(O)=O
Synonyms [en]
N6-Methyl-L-lysine; N(6)-methyllysine; MeLys; epsilon-N-methyllysine; N(6)-methyl-L-lysine; (2S)-2-amino-6-(methylamino)hexanoic acid
Last reviewed on 2024-06-28.
Cite this Page
N6-Methyl-L-lysine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000014957). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
N(6)-Methyllysine is a naturally occurring amino acid found in human biofluids. N-monomethyl-lysine is generated by metabolic transmethylation of endogenous lysine. Lysine methylation displays the highest degree of complexity among known covalent histone modifications, with each site of methylation regulating the association of different effector molecules. The versatility of lysine methylation marks is perhaps best exemplified by modifications implicated in transcriptional regulation as well as being required for double-strand break repair in several organisms. Identification of the numerous biological functions encoded by histone lysine methylation is a major area of research interest, as these mechanisms are intimately associated with cellular senescence, genomic instability, and leukemogenesis. While multiple sites of lysine methylation have been linked with gene activation, each modification is distributed to unique positions across the active gene. (PMID: 17030614, 1122639, 15756599, 3111294).
DBLinks
- CAS Registry Number: 1188-07-4
- PubChem CID: 164795
- ChEBI: 17604
- HMDB: HMDB0002038
- LipidMaps:
- KEGG: C02728
- BioCyc:
- NCBI MeSH: epsilon-N-methyllysine
- Wikipedia:
Other DBLinks
- CAS Registry Number: 118021-34-4
- CAS Registry Number: 1188-07-4
- CAS Registry Number: 647823-69-6
- CAS Registry Number: 7622-29-9
- PubChem: 164795
- ChEBI: ChEBI:17604
- ChEBI: ChEBI:64349
- HMDB: HMDB0002038
- KEGG: C02728
- NCBI MeSH: epsilon-N-methyllysine
- DrugBank: DB01714
- RefMet: RM0020527
- MoNA: MoNA019877
- Metlin: METLIN_49
- Coconut NaturalProduct: CNP0107109.1
- Coconut NaturalProduct: CNP0253438.1
Class / Ontology
- WishartLab ClassyFire: [Amino acids, peptides, and analogues] Amino acids, peptides, and analogues
- RefMet: [Amino acids] Amino acids
- ChEBI: [CHEBI:17604] N(6)-methyl-L-lysine
- Coconut NaturalProduct: [Aminoacids] Aminoacids
| ID | EC Number | Name |
|---|---|---|
| KEGG:R00612 | 1.5.3.4 | N6-methyl-L-lysine:oxygen oxidoreductase (demethylating) |