Metformin (BioCAD00000013922)

blood feces urine erythrocyte liver skeletal muscle plant natural products

Metabolite Card

Formula: C4H11N5 (129.1014)
SMILES: CN(C)C(=N)NC(N)=N

Synonyms [en]

metformin; 1,1-Dimethylbiguanide; Dimethylbiguanide; Metformine; Metforminum; Metformina

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Metformin. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000013922). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

1,1-Dimethylbiguanide, commonly known as metformin, is a member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1. It has a role as a hypoglycemic agent, a xenobiotic and an environmental contaminant. It derives from a biguanide. It is a conjugate base of a metformin(1+). Metformin is a biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. Metformin is the most popular anti-diabetic drug in the United States and one of the most prescribed drugs in the country overall, with nearly 35 million prescriptions filled in 2006 for generic metformin alone. It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain and is taken by mouth. It is sometimes used as an off-label augment to attenuate the risk of weight gain in people who take antipsychotics as well as phenelzine.

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 1115-70-4
  • CAS Registry Number: 657-24-9
  • PubChem: 4091
  • ChEBI: ChEBI:6801
  • HMDB: HMDB0001921
  • HMDB: HMDB01921
  • KEGG: C07151
  • NCBI MeSH: Metformin
  • Wikipedia: Metformin
  • DrugBank: DB00331
  • RefMet: RM0020588
  • MoNA: AU112701
  • MoNA: AU112702
  • MoNA: AU112703
  • MoNA: EA255001
  • MoNA: EA255002
  • MoNA: EA255003
  • MoNA: EA255004
  • MoNA: EA255005
  • MoNA: EA255006
  • MoNA: EA255007
  • MoNA: EA255008
  • MoNA: EA255009
  • MoNA: EA255010
  • MoNA: EA255011
  • MoNA: EA255012
  • MoNA: EA255013
  • MoNA: EA255014
  • MoNA: FiehnHILIC000513
  • MoNA: HMDB0001921_ms_ms_1843
  • MoNA: HMDB0001921_ms_ms_1844
  • MoNA: HMDB0001921_ms_ms_1845
  • MoNA: KO003372
  • MoNA: KO003373
  • MoNA: KO003374
  • MoNA: KO003375
  • MoNA: KO003376
  • MoNA: MoNA011155
  • MoNA: MoNA011156
  • MoNA: MoNA011157
  • MoNA: MoNA011158
  • MoNA: MoNA037601
  • MoNA: MoNA038842
  • MoNA: PS002201
  • MoNA: PS002202
  • MoNA: PS002203
  • MoNA: PS002204
  • MoNA: PS002205
  • MoNA: SM867803
  • MoNA: TUE00511
  • MoNA: TUE00512
  • MoNA: TUE00513
  • MoNA: UF412401
  • MoNA: UF412402
  • MoNA: UF412403
  • MoNA: UF412404
  • MoNA: WA000492
  • MoNA: WA000493
  • MoNA: WA000494
  • MoNA: WA000495
  • Metlin: METLIN_1180
  • Coconut NaturalProduct: CNP0126469.0
  • Coconut NaturalProduct: CNP0499713.0

Class / Ontology

Metabolic Network
ID EC Number Name
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