Glycochenodeoxycholate (BioCAD00000011748)

bile blood feces urine placenta prostate

Metabolite Card

Formula: C26H43NO5 (449.3141)
SMILES: [H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(=O)NCC(O)=O

Synonyms [en]

Glycochenodeoxycholic Acid; Glycochenodeoxycholate; Chenodeoxyglycocholate; GCDCA; Chenodeoxycholylglycine; Chenodeoxyglycocholic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Glycochenodeoxycholate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000011748). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Chenodeoxycholic acid glycine conjugate is an acyl glycine and a bile acid-glycine conugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environment. In hepatocytes, both primary and secondary bile acids undergo amino acid conjugation at the C-24 carboxylic acid on the side chain, and almost all bile acids in the bile duct therefore exist in a glycine conjugated form (PMID: 16949895). This compound usually exists as the sodium salt and acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.

Extracellular
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 16564-43-5
  • CAS Registry Number: 640-79-9
  • PubChem: 12544
  • PubChem: 440686
  • ChEBI: ChEBI:36274
  • HMDB: HMDB0000637
  • HMDB: HMDB0006898
  • HMDB: HMDB00708 HMDB00637
  • LipidMaps: LMST05030003
  • LipidMaps: LMST05030008
  • KEGG: C05462
  • KEGG: C05466
  • BioCyc: GLYCOCHENODEOXYCHOLIC_ACID
  • NCBI MeSH: Glycochenodeoxycholic Acid
  • Wikipedia: Glycochenodeoxycholic_acid
  • DrugBank: DB02123
  • RefMet: RM0135850
  • MoNA: CCMSLIB00001059061
  • MoNA: CCMSLIB00005435453
  • MoNA: CCMSLIB00005435454
  • MoNA: CCMSLIB00005435455
  • MoNA: CCMSLIB00005435510
  • MoNA: CCMSLIB00005435511
  • MoNA: CCMSLIB00005435512
  • MoNA: CCMSLIB00005464545
  • MoNA: CCMSLIB00005464546
  • MoNA: CCMSLIB00005464547
  • MoNA: CCMSLIB00005464571
  • MoNA: LipidBlast2022_199600
  • MoNA: LipidBlast2022_199801
  • MoNA: LipidBlast2022_199802
  • MoNA: MoNA023857
  • MoNA: MoNA023899
  • MoNA: MoNA032373
  • MoNA: MoNA032374
  • MoNA: MoNA032377
  • MoNA: MoNA033253
  • MoNA: MoNA033257
  • MoNA: MoNA033259
  • MoNA: MoNA034398
  • MoNA: MoNA034400
  • MoNA: MoNA034401
  • MoNA: MoNA035022
  • MoNA: MoNA035024
  • MoNA: MoNA035025
  • MoNA: MoNA035438
  • MoNA: MoNA035440
  • MoNA: MoNA035442
  • MoNA: MoNA037271
  • MoNA: MoNA037574
  • MoNA: MoNA038003
  • MoNA: MoNA038155
  • MoNA: MoNA038325
  • MoNA: MT000063
  • MoNA: RP005201
  • MoNA: RP005202
  • MoNA: RP005203
  • Metlin: METLIN_43193
  • Coconut NaturalProduct: CNP0240348.1
  • Coconut NaturalProduct: CNP0567109.1

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R03975 3.5.1.24 glycochenodeoxycholate amidohydrolase
KEGG:R07289 2.8.2.34 3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase
KEGG:R08744 2.3.1.65 3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:glycine N-choloyltransferase;
BioCyc:RXN-17388 3.5.1.24 GLYCOCHENODEOXYCHOLIC_ACID + WATER --> CPD-15189 + GLY
BioCyc:2.8.2.34-RXN 2.8.2.34 PAPS + GLYCOCHENODEOXYCHOLIC_ACID --> 3-5-ADP + GLYCOCHENODEOXYCHOLATE-7-SULFATE + PROTON
BioCyc:RXN-9851 2.3.1.65 CPD-10556 + GLY --> PROTON + GLYCOCHENODEOXYCHOLIC_ACID + CO-A
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Organism Source

Taxonomy Source

  1. Homo sapiens [ncbi taxid: 9606]

Pathway Synthetic

pathway id name
WikiPathways:WP5176 Disorders of bile acid synthesis and biliary transport
WikiPathways:WP661 Glucose homeostasis
View All Pathways