Dodecanedioic acid (BioCAD00000010285)

blood feces urine

Metabolite Card

Formula: C12H22O4 (230.1518)
SMILES: OC(=O)CCCCCCCCCCC(O)=O

Synonyms [en]

dodecanedioic acid; Decamethylenedicarboxylic acid; 1,10-decanedicarboxylic acid; dodecandioic acid; 1,12-Dodecanedioic acid; Corfree M 2

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Dodecanedioic acid. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000010285). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Dodecanedioic acid is an aliphatic dicarboxylic acid containing 12 carbon atoms. More formally it is an alpha,omega-dicarboxylic acid with both the first and last carbons of the aliphatic chain having carboxylic acids. Dodecanedioic acid is water soluble. It can be produced in yeast and fungi through the oxidation of dodecane via fungal peroxygenases (PMID: 27573441). High levels of dodecanedioic acid is an indicator of hepatic carnitine palmitoyltransferase I (CPT IA) deficiency (PMID: 16146704). CPT IA deficiency is characterized by hypoketotic dicarboxylic aciduria with high urinary levels of dodecanedioic acid. It is thought that carnitine palmitoyltransferase I may play a role in the uptake of long-chain dicarboxylic acids by mitochondria after their initial shortening by beta-oxidation in peroxisomes (PMID: 16146704). CPT IA deficiency is characterized by acute encephalopathy with hypoglycemia and hepatomegaly.

Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 53037-60-8
  • CAS Registry Number: 693-23-2
  • PubChem: 12736
  • ChEBI: ChEBI:4676
  • HMDB: HMDB0000623
  • HMDB: HMDB00623
  • LipidMaps: LMFA01170009
  • KEGG: C02678
  • BioCyc: CPD-10670
  • NCBI MeSH: dodecanedioic acid
  • Wikipedia: Dodecanedioic acid
  • Wikipedia: Dodecanedioic_acid
  • RefMet: RM0153694
  • MoNA: HMDB0000623_ms_ms_846
  • MoNA: HMDB0000623_ms_ms_847
  • MoNA: HMDB0000623_ms_ms_848
  • MoNA: KO000594
  • MoNA: KO000595
  • MoNA: KO000596
  • MoNA: KO000597
  • MoNA: KO000598
  • MoNA: LU027551
  • MoNA: LU027552
  • MoNA: LU027553
  • MoNA: LU027554
  • MoNA: LU027555
  • MoNA: LU027556
  • Metlin: METLIN_5596
  • Coconut NaturalProduct: CNP0293008.0

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

  1. Homo sapiens [ncbi taxid: 9606]

Pathway Synthetic

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