EC: 6.5.1.1

DNA ligase (ATP) (poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP))

enzyme lambda metabolic reaction experiment
uniprot:P9WNV5 [DNA ligase (ATP)(Enzyme) wildtype His10-LigB]

ATP + n+m_m_n_DNA + n+m_m_n_DNA -> n+m_m_n_DNA + Diphosphate + AMP
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 5 mM DTT, 10 mM MgCl2
PH: 7.5
Temperature: 37

Pathways

pathway id name
Reactome:R-HSA-9856651 MITF-M-dependent gene expression
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-HSA-9730414 MITF-M-regulated melanocyte development
Reactome:R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Reactome:R-SCE-110362 POLB-Dependent Long Patch Base Excision Repair
Reactome:R-CEL-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Reactome:R-CEL-5651801 PCNA-Dependent Long Patch Base Excision Repair
Reactome:R-CEL-69242 S Phase
Reactome:R-CEL-73894 DNA Repair
Reactome:R-DDI-73894 DNA Repair
Reactome:R-DDI-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Reactome:R-DDI-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Reactome:R-DDI-69239 Synthesis of DNA
Reactome:R-DDI-69190 DNA strand elongation
Reactome:R-DDI-69186 Lagging Strand Synthesis
Reactome:R-DME-69239 Synthesis of DNA
Reactome:R-DME-69278 Cell Cycle, Mitotic
Reactome:R-DME-73884 Base Excision Repair
Reactome:R-DME-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Reactome:R-DME-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Reactome:R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Reactome:R-HSA-5693532 DNA Double-Strand Break Repair
Reactome:R-HSA-5693538 Homology Directed Repair
Reactome:R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Reactome:R-HSA-69239 Synthesis of DNA
Reactome:R-HSA-73886 Chromosome Maintenance
Reactome:R-HSA-180786 Extension of Telomeres
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-162587 HIV Life Cycle
Reactome:R-MMU-1640170 Cell Cycle
Reactome:R-MMU-69239 Synthesis of DNA
Reactome:R-MMU-174417 Telomere C-strand (Lagging Strand) Synthesis
Reactome:R-MMU-73933 Resolution of Abasic Sites (AP sites)
Reactome:R-MMU-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Reactome:R-MMU-5685939 HDR through MMEJ (alt-NHEJ)
Reactome:R-MMU-5358508 MMR
Reactome:R-RNO-69190 DNA strand elongation
Reactome:R-RNO-69186 Lagging Strand Synthesis
Reactome:R-RNO-157579 Telomere Maintenance
Reactome:R-RNO-73894 DNA Repair
Reactome:R-RNO-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Reactome:R-RNO-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Reactome:R-SCE-1640170 Cell Cycle
Reactome:R-SCE-69239 Synthesis of DNA
Reactome:R-SCE-69186 Lagging Strand Synthesis
Reactome:R-SPO-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Reactome:R-CEL-69278 Cell Cycle, Mitotic
Reactome:R-CEL-69306 DNA Replication
Reactome:R-CEL-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Reactome:R-CEL-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Reactome:R-DDI-73933 Resolution of Abasic Sites (AP sites)
Reactome:R-DDI-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Reactome:R-DDI-5693532 DNA Double-Strand Break Repair
Reactome:R-DDI-5358508 MMR
Reactome:R-DDI-69306 DNA Replication
Reactome:R-DME-69242 S Phase
Reactome:R-DME-73894 DNA Repair
Reactome:R-DME-5358508 MMR
Reactome:R-HSA-1266738 Developmental Biology
Reactome:R-HSA-73884 Base Excision Repair
Reactome:R-HSA-73933 Resolution of Abasic Sites (AP sites)
Reactome:R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Reactome:R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
Reactome:R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Reactome:R-HSA-1640170 Cell Cycle
Reactome:R-HSA-157579 Telomere Maintenance
Reactome:R-HSA-162906 HIV Infection
Reactome:R-HSA-162592 Integration of provirus
Reactome:R-HSA-69306 DNA Replication
Reactome:R-MMU-174414 Processive synthesis on the C-strand of the telomere
Reactome:R-MMU-5651801 PCNA-Dependent Long Patch Base Excision Repair
Reactome:R-RNO-1640170 Cell Cycle
Reactome:R-RNO-69239 Synthesis of DNA
Reactome:R-RNO-174417 Telomere C-strand (Lagging Strand) Synthesis
Reactome:R-RNO-69306 DNA Replication
Reactome:R-RNO-73933 Resolution of Abasic Sites (AP sites)
Reactome:R-RNO-5358508 MMR
Reactome:R-SCE-73884 Base Excision Repair
Reactome:R-SCE-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Reactome:R-SCE-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Reactome:R-SPO-69306 DNA Replication
Reactome:R-SPO-1640170 Cell Cycle
Reactome:R-SPO-69242 S Phase
Reactome:R-SPO-73884 Base Excision Repair
Reactome:R-SPO-5651801 PCNA-Dependent Long Patch Base Excision Repair
Reactome:R-SPO-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Reactome:R-SPO-5358508 MMR
Reactome:R-CEL-1640170 Cell Cycle
Reactome:R-CEL-69239 Synthesis of DNA
Reactome:R-CEL-69186 Lagging Strand Synthesis
Reactome:R-CEL-73884 Base Excision Repair
Reactome:R-CEL-73933 Resolution of Abasic Sites (AP sites)
Reactome:R-CEL-5696398 Nucleotide Excision Repair
Reactome:R-CEL-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome:R-DDI-73884 Base Excision Repair
Reactome:R-DDI-110381 Resolution of AP sites via the single-nucleotide replacement pathway
Reactome:R-DDI-110362 POLB-Dependent Long Patch Base Excision Repair
Reactome:R-DDI-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Reactome:R-DDI-69183 Processive synthesis on the lagging strand
Reactome:R-DDI-1640170 Cell Cycle
Reactome:R-DME-69306 DNA Replication
Reactome:R-DME-69190 DNA strand elongation
Reactome:R-DME-69186 Lagging Strand Synthesis
Reactome:R-DME-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Reactome:R-GGA-1670466 DNA replication and repair
Reactome:R-GGA-353371 Double strand break repair
Reactome:R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway
Reactome:R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair
Reactome:R-HSA-69278 Cell Cycle, Mitotic
Reactome:R-HSA-69190 DNA strand elongation
Reactome:R-HSA-69186 Lagging Strand Synthesis
Reactome:R-HSA-174414 Processive synthesis on the C-strand of the telomere
Reactome:R-HSA-162594 Early Phase of HIV Life Cycle
Reactome:R-HSA-164843 2-LTR circle formation
Reactome:R-MMU-69190 DNA strand elongation
Reactome:R-MMU-69186 Lagging Strand Synthesis
Reactome:R-MMU-157579 Telomere Maintenance
Reactome:R-MMU-73894 DNA Repair
Reactome:R-MMU-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Reactome:R-MMU-5693571 Nonhomologous End-Joining (NHEJ)
Reactome:R-MMU-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Reactome:R-RNO-69278 Cell Cycle, Mitotic
Reactome:R-RNO-69242 S Phase
Reactome:R-RNO-69183 Processive synthesis on the lagging strand
Reactome:R-RNO-73886 Chromosome Maintenance
Reactome:R-RNO-180786 Extension of Telomeres
Reactome:R-RNO-73884 Base Excision Repair
Reactome:R-RNO-110362 POLB-Dependent Long Patch Base Excision Repair
Reactome:R-RNO-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Reactome:R-SCE-73933 Resolution of Abasic Sites (AP sites)
Reactome:R-SCE-5358508 MMR
Reactome:R-SCE-69190 DNA strand elongation
Reactome:R-SCE-69183 Processive synthesis on the lagging strand
Reactome:R-SPO-69239 Synthesis of DNA
Reactome:R-SPO-69186 Lagging Strand Synthesis
Reactome:R-SPO-73933 Resolution of Abasic Sites (AP sites)
Reactome:R-SPO-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Reactome:R-CEL-69190 DNA strand elongation
Reactome:R-CEL-69183 Processive synthesis on the lagging strand
Reactome:R-CEL-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Reactome:R-CEL-5358508 MMR
Reactome:R-DDI-5693571 Nonhomologous End-Joining (NHEJ)
Reactome:R-DDI-69278 Cell Cycle, Mitotic
Reactome:R-DDI-69242 S Phase
Reactome:R-DME-69183 Processive synthesis on the lagging strand
Reactome:R-DME-1640170 Cell Cycle
Reactome:R-DME-73933 Resolution of Abasic Sites (AP sites)
Reactome:R-DME-5651801 PCNA-Dependent Long Patch Base Excision Repair
Reactome:R-GGA-353377 DNA repair
Reactome:R-GGA-353423 Non-homologous end joining (NHEJ)
Reactome:R-HSA-73894 DNA Repair
Reactome:R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
Reactome:R-HSA-5685939 HDR through MMEJ (alt-NHEJ)
Reactome:R-HSA-5358508 MMR
Reactome:R-HSA-69242 S Phase
Reactome:R-HSA-69183 Processive synthesis on the lagging strand
Reactome:R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-MMU-69278 Cell Cycle, Mitotic
Reactome:R-MMU-69242 S Phase
Reactome:R-MMU-69183 Processive synthesis on the lagging strand
Reactome:R-MMU-73886 Chromosome Maintenance
Reactome:R-MMU-180786 Extension of Telomeres
Reactome:R-MMU-69306 DNA Replication
Reactome:R-MMU-73884 Base Excision Repair
Reactome:R-MMU-110381 Resolution of AP sites via the single-nucleotide replacement pathway
Reactome:R-MMU-110362 POLB-Dependent Long Patch Base Excision Repair
Reactome:R-MMU-5693532 DNA Double-Strand Break Repair
Reactome:R-MMU-5693538 Homology Directed Repair
Reactome:R-MMU-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Reactome:R-RNO-174414 Processive synthesis on the C-strand of the telomere
Reactome:R-RNO-5651801 PCNA-Dependent Long Patch Base Excision Repair
Reactome:R-SCE-73894 DNA Repair
Reactome:R-SCE-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Reactome:R-SCE-69278 Cell Cycle, Mitotic
Reactome:R-SCE-69242 S Phase
Reactome:R-SCE-69306 DNA Replication
Reactome:R-SPO-69190 DNA strand elongation
Reactome:R-SPO-69183 Processive synthesis on the lagging strand
Reactome:R-SPO-69278 Cell Cycle, Mitotic
Reactome:R-SPO-73894 DNA Repair
Reactome:R-SPO-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Reactome:R-SPO-5696398 Nucleotide Excision Repair
Reactome:R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
WikiPathways:WP5287 17q12 copy number variation syndrome
WikiPathways:WP5056 Burn wound healing