EC: 4.1.1.1

pyruvate decarboxylase (2-oxo-acid carboxy-lyase (aldehyde-forming))

enzyme lambda metabolic reaction experiment
uniprot:P26263 [pyruvate decarboxylase(Enzyme) wildtype isozyme Pdc6p]

Pyruvate -> Acetaldehyde + CO2
(( (( (PDC6 * PDCPDC6kcat) ) * PYR) ) / (PDCPDC6Kpyr * (1 + (PYR / PDCPDC6Kpyr)))) buffer: *
PH: 7
Temperature: 36
uniprot:P16467 [pyruvate decarboxylase(Enzyme) wildtype isozyme Pdc5p]

Pyruvate -> Acetaldehyde + CO2
(( (( (PDC5 * PDCPDC5kcat) ) * PYR) ) / (PDCPDC5Kpyr * (1 + (PYR / PDCPDC5Kpyr)))) buffer: *
PH: 7
Temperature: 36
uniprot:P06169 [pyruvate decarboxylase(Enzyme) wildtype isozyme Pdc1p]

Pyruvate -> CO2 + Acetaldehyde
(( (( (PDC1 * PDCPDC1kcat) ) * PYR) ) / (PDCPDC1Kpyr * (1 + (PYR / PDCPDC1Kpyr)))) buffer: *
PH: 7
Temperature: 36
- [Mg2+]

Pyruvate -> Acetaldehyde + CO2
(( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 100 mM His-HCl, 0.26 mM NADH, 10 units/ml yeast ADH
PH: 5.8
Temperature: 25
- [Mg2+]

Pyruvate -> Acetaldehyde + CO2
(( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 100 mM His-HCl, 0.26 mM NADH, 10 units/ml yeast ADH
PH: 6.6
Temperature: 25
- [Mg2+]

Pyruvate -> CO2 + Acetaldehyde
(( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 100 mM His-HCl, 0.26 mM NADH, 10 units/ml yeast ADH
PH: 5.8
Temperature: 25
- [Mg2+]

Pyruvate -> CO2 + Acetaldehyde
(( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 100 mM His-HCl, 0.26 mM NADH, 10 units/ml yeast ADH
PH: 6.6
Temperature: 25
- [Thiamine diphosphate]

Pyruvate -> CO2 + Acetaldehyde
(( (Vmax * S) ) / (Km + S)) buffer: 300 mM potassium, 245 mM glutamate, 50 mM phosphate, 20 mM sodium, 2 mM magnesium, 2.5-10 mM sulphate, 0.5 mM calcium, 0.15 mM NADH
PH: 6.8
Temperature: 30
- [Mg2+]

Pyruvate -> CO2 + Acetaldehyde
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM His-HCl, 0.26 mM NADH, 10 units/ml yeast ADH
PH: 5.8
Temperature: 25
uniprot:A2XFI3 [Mg2+]

Pyruvate -> CO2 + Acetaldehyde
(( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM Mes/NaOH, 0.12 mM NADH, 600 nkat/ml yeast ADH
PH: 6.25
Temperature: 25
- [pyruvate decarboxylase(Enzyme) wildtype low-Mr PDC]

Pyruvate -> CO2 + Acetaldehyde
(( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: *
PH: 7
Temperature: 36
uniprot:P06169 [pyruvate decarboxylase(Enzyme) wildtype isozyme Pdc1p, C-terminal GST-tag]

Pyruvate -> Acetaldehyde + CO2
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 100 mM MES, 100 mM KCl, 0.2 mM thiamine pyrophosphate, 88 U/ml alcohol dehydrogenase, 0.15 mM NADH, 5 mM MgCl2
PH: 6.5
Temperature: 30
uniprot:P16467 [pyruvate decarboxylase(Enzyme) wildtype isozyme Pdc5p, C-terminal GST-tag]

Pyruvate -> Acetaldehyde + CO2
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 100 mM MES, 100 mM KCl, 0.2 mM thiamine pyrophosphate, 88 U/ml alcohol dehydrogenase, 0.15 mM NADH, 5 mM MgCl2
PH: 6.5
Temperature: 30
uniprot:P26263 [pyruvate decarboxylase(Enzyme) wildtype isozyme Pdc6p, C-terminal GST-tag]

Pyruvate -> CO2 + Acetaldehyde
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 100 mM MES, 100 mM KCl, 0.2 mM thiamine pyrophosphate, 88 U/ml alcohol dehydrogenase, 0.15 mM NADH, 5 mM MgCl2
PH: 6.5
Temperature: 30
- [pyruvate decarboxylase(Enzyme) wildtype]

Pyruvate -> Acetaldehyde + CO2
(( (( (cytosol * Vmax_12) ) * (( (PYR / Kpyr_12) ) ^ nH_12)) ) / (1 + (( (PYR / Kpyr_12) ) ^ nH_12))) buffer: *
PH: 7
Temperature: 36
uniprot:P06169 [pyruvate decarboxylase(Enzyme) wildtype isozyme PDC1]

Pyruvate -> Acetaldehyde + CO2
(( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 100 mM MES, 100 mM KCl, 5 mM MgCl2, 0.2 mM thiamine pyrophosphate, 88 U/ml alcohol dehydrogenase, 0.15 mM NADH
PH: 6.5
Temperature: 30
uniprot:P16467 [pyruvate decarboxylase(Enzyme) wildtype isozyme PDC5]

Pyruvate -> CO2 + Acetaldehyde
(( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 100 mM MES, 100 mM KCl, 5 mM MgCl2, 0.2 mM thiamine pyrophosphate, 88 U/ml alcohol dehydrogenase, 0.15 mM NADH
PH: 6.5
Temperature: 30
uniprot:P06169 [pyruvate decarboxylase(Enzyme) wildtype isozyme PDC1]

Pyruvate -> CO2 + Acetaldehyde
(( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 100 mM MES, 100 mM KCl, 5 mM MgCl2, 0.2 mM thiamine pyrophosphate, 88 U/ml alcohol dehydrogenase, 0.15 mM NADH
PH: 6.5
Temperature: 30
uniprot:P16467 [pyruvate decarboxylase(Enzyme) wildtype isozyme PDC5]

Pyruvate -> Acetaldehyde + CO2
(( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 100 mM MES, 100 mM KCl, 5 mM MgCl2, 0.2 mM thiamine pyrophosphate, 88 U/ml alcohol dehydrogenase, 0.15 mM NADH
PH: 6.5
Temperature: 30
uniprot:P26263 [pyruvate decarboxylase(Enzyme) wildtype isozyme PDC6]

Pyruvate -> Acetaldehyde + CO2
(( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 100 mM MES, 100 mM KCl, 5 mM MgCl2, 0.2 mM thiamine pyrophosphate, 88 U/ml alcohol dehydrogenase, 0.15 mM NADH
PH: 6.5
Temperature: 30
- [pyruvate decarboxylase(Enzyme) wildtype]

Pyruvate -> CO2 + Acetaldehyde
(( (( (( (cytosol * VmPDC) ) * (PYR ^ nPDC)) ) / (KmPDCPYR ^ nPDC)) ) / (1 + (( (PYR ^ nPDC) ) / (KmPDCPYR ^ nPDC)))) buffer: *
PH: 7
Temperature: 36
uniprot:P06169 [pyruvate decarboxylase(Enzyme) wildtype Pyruvate decarboxylase isozyme 1]

Pyruvate -> Acetaldehyde + CO2
(( (( (kcat * Et) ) * S) ) / (Ks + S)) buffer: 0.2 mM thiamine(1+) diphosphate chloride, 100.0 mM 2-(N-morpholino)ethanesulfonic acid, 5.0 mM magnesium dichloride, NADH, 100.0 mM potassium chloride
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) wildtype]

Pyruvate -> Acetaldehyde + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I476F]

Pyruvate -> CO2 + Acetaldehyde
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I472A]

Pyruvate -> CO2 + Acetaldehyde
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I472A/I476F]

Pyruvate -> Acetaldehyde + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I472A/I476F]

2_Oxobutyrate -> Propanal + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I476F]

2_Oxobutyrate -> CO2 + Propanal
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I472A]

2_Oxobutyrate -> CO2 + Propanal
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) wildtype]

2_Oxobutyrate -> CO2 + Propanal
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I472A]

2_Oxopentanoate -> Butanal + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I472A/I476F]

2_Oxopentanoate -> Butanal + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) wildtype]

2_Oxopentanoate -> Butanal + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I476F]

2_Oxopentanoate -> CO2 + Butanal
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I472A/I476F]

2_Oxohexanoate -> CO2 + Pentanal
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I472A]

2_Oxohexanoate -> Pentanal + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I476F]

2_Oxohexanoate -> CO2 + Pentanal
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I472A/I476F]

alpha_Oxo_benzeneacetic_acid -> Benzaldehyde + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I472A]

alpha_Oxo_benzeneacetic_acid -> Benzaldehyde + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) wildtype]

2_Oxohexanoate -> Pentanal + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I472A]

2_Keto_4_methylhexanoic_acid -> 3_Methylpentanal + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) mutant I472A/I476F]

2_Keto_4_methylhexanoic_acid -> 3_Methylpentanal + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P06672 [pyruvate decarboxylase(Enzyme) wildtype]

2_Keto_4_methylhexanoic_acid -> CO2 + 3_Methylpentanal
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mes-KOH or 50 mM potassium phosphate, 2 mM MgSO4, 0.1 mM ThDP, 0.18 mM NADH, 10 U/ml alcohol dehydrogenase from yeast
PH: 6.5
Temperature: 30
uniprot:P16467 [pyruvate decarboxylase(Enzyme) wildtype isozyme 2]

Pyruvate -> CO2 + Acetaldehyde
(( (( (kcat * Et) ) * S) ) / (Ks + S)) buffer: 0.2 mM thiamine(1+) diphosphate chloride, 0.0 mM Alcohol dehydrogenase, 100.0 mM 2-(N-morpholino)ethanesulfonic acid, 5.0 mM magnesium dichloride, 0.15 mM NADH, 100.0 mM potassium chloride
PH: 6.5
Temperature: 30
uniprot:Q8L388 [pyruvate decarboxylase(Enzyme) wildtype]

Pyruvate -> Acetaldehyde + CO2
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM sodium citrate, 0.15 mM NADH, 5 mM MgCl2, 0.1 mM thiamine pyrophosphate, 10 U Alcohol dehydrogenase from Saccharomyces cerevisae
PH: 5
Temperature: 25
uniprot:Q8L388 [pyruvate decarboxylase(Enzyme) wildtype]

Pyruvate -> CO2 + Acetaldehyde
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM sodium citrate, 0.15 mM NADH, 5 mM MgCl2, 0.1 mM thiamine pyrophosphate, 10 U Alcohol dehydrogenase from Saccharomyces cerevisae
PH: 7
Temperature: 25
uniprot:P06672 [pyruvate decarboxylase(Enzyme) wildtype]

Pyruvate -> Acetaldehyde + CO2
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM sodium citrate, 0.15 mM NADH, 5 mM MgCl2, 0.1 mM thiamine pyrophosphate, 10 U Alcohol dehydrogenase from Saccharomyces cerevisae
PH: 7
Temperature: 25
uniprot:P06672 [pyruvate decarboxylase(Enzyme) wildtype]

Pyruvate -> CO2 + Acetaldehyde
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM sodium citrate, 0.15 mM NADH, 5 mM MgCl2, 0.1 mM thiamine pyrophosphate, 10 U Alcohol dehydrogenase from Saccharomyces cerevisae
PH: 6
Temperature: 25
uniprot:Q8KTX6 [pyruvate decarboxylase(Enzyme) wildtype]

Pyruvate -> CO2 + Acetaldehyde
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM sodium citrate, 0.15 mM NADH, 5 mM MgCl2, 0.1 mM thiamine pyrophosphate, 10 U Alcohol dehydrogenase from Saccharomyces cerevisae
PH: 7
Temperature: 25
uniprot:Q8KTX6 [pyruvate decarboxylase(Enzyme) wildtype]

Pyruvate -> CO2 + Acetaldehyde
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM sodium citrate, 0.15 mM NADH, 5 mM MgCl2, 0.1 mM thiamine pyrophosphate, 10 U Alcohol dehydrogenase from Saccharomyces cerevisae
PH: 6
Temperature: 25

Pathways

pathway id name
BioCyc:META_PWY-7345 superpathway of anaerobic sucrose degradation
PlantCyc:PLANT_PWY-7345 superpathway of anaerobic sucrose degradation
PathBank:SMP0002442 Phenylalanine Metabolism
PathBank:SMP0002457 Tyrosine Metabolism