EC: 3.6.1.55

8-oxo-dGTP diphosphatase (8-oxo-dGTP diphosphohydrolase)

enzyme lambda metabolic reaction experiment
uniprot:Q12524 [8-oxo-dGTP diphosphatase(Enzyme) wildtype]

Coenzyme_A + H2O -> Adenosine_3',5'_bisphosphate + 4'_Phosphopantetheine
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM 1,3-bis[tris(hydroxymethyl)methylamino]propane-HCl, 5 mM MgCl2, 1 mM DTT
PH: 7
Temperature: 37
uniprot:Q12524 [8-oxo-dGTP diphosphatase(Enzyme) wildtype]

CoA_disulfide + H2O -> Adenosine_3',5'_bisphosphate + CoA_4'_Phosphopantetheine_disulfide
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM 1,3-bis[tris(hydroxymethyl)methylamino]propane-HCl, 5 mM MgCl2, 1 mM DTT
PH: 7
Temperature: 37
uniprot:P08337 [Mg2+]

H2O + dTTP -> dTMP + Diphosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

dCTP + H2O -> dCMP + Diphosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

H2O + dGTP -> dGMP + Diphosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

H2O + 8_oxo_dGTP -> 8_oxo_dGMP + Diphosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

8_oxo_dGDP + H2O -> 8_oxo_dGMP + Phosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

dTDP + H2O -> Phosphate + dTMP
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

GDP + H2O -> Phosphate + GMP
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

GTP + H2O -> GMP + Diphosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

H2O + dCDP -> dCMP + Phosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

H2O + dATP -> dAMP + Diphosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

8_oxo_GDP + H2O -> 8_oxo_GMP + Phosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

dADP + H2O -> dAMP + Phosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

H2O + dGDP -> dGMP + Phosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30
uniprot:P08337 [Mg2+]

8_oxo_GTP + H2O -> Diphosphate + 8_oxo_GMP
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 80 µg/ml BSA, 40 mM NaCl, 5 mM DTT, 2% glycerol
PH: 8
Temperature: 30

Pathways

pathway id name
BioCyc:ARA_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:ARA_PWY-6502 oxidized GTP and dGTP detoxification
BioCyc:ARA_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:ARA_PWY-5381 pyridine nucleotide cycling (plants)
BioCyc:MTBH37RV_PWY-6502 oxidized GTP and dGTP detoxification
BioCyc:BSUB_PWY-7177 UTP and CTP dephosphorylation II
BioCyc:META_PWY-6502 oxidized GTP and dGTP detoxification
BioCyc:META_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:ARA_PWY-3742 tetrahydrofolate biosynthesis II
BioCyc:META_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:META_PWY-7177 UTP and CTP dephosphorylation II
PlantCyc:ARA_PWY-3742 tetrahydrofolate biosynthesis II
PlantCyc:PLANT_PWY-6502 oxidized GTP and dGTP detoxification
PlantCyc:ARA_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:PLANT_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:ARA_PWY-6502 oxidized GTP and dGTP detoxification
PlantCyc:ARA_PWY-6612 superpathway of tetrahydrofolate biosynthesis
PlantCyc:PLANT_PWY-3742 tetrahydrofolate biosynthesis II
PlantCyc:PLANT_PWY-6612 superpathway of tetrahydrofolate biosynthesis
PathBank:SMP0012013 Pterin Biosynthesis (Folate Precursor)