EC: 2.4.1.83

dolichyl-phosphate beta-D-mannosyltransferase (GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase)

enzyme lambda metabolic reaction experiment
uniprot:P14020 [dolichyl-phosphate beta-D-mannosyltransferase(Enzyme) wildtype]

GDPmannose + Dolichyl_phosphate -> Dolichyl_phosphate_D_mannose + GDP		 (( (Vmax * A) ) / (Km + A)) buffer: 30 mM Hepes, 150 µM EDTA, 30 µM dithiothreitol, 3% glycerol, 90 mM NaCl, 0.25% Triton X-100, 10 mM MnCl2, 1% Me2SO
PH: 7
Temperature: 37
uniprot:P14020 [dolichyl-phosphate beta-D-mannosyltransferase(Enzyme) wildtype phosphorylated by cAMP-dependent protein kinase]

GDPmannose + Dolichyl_phosphate -> GDP + Dolichyl_phosphate_D_mannose		 (( (Vmax * A) ) / (Km + A)) buffer: 30 mM Hepes, 150 µM EDTA, 30 µM dithiothreitol, 3% glycerol, 90 mM NaCl, 0.25% Triton X-100, 10 mM MnCl2, 1% Me2SO
PH: 7
Temperature: 37

Pathways

pathway id name
BioCyc:META_MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS protein N-glycosylation initial phase (eukaryotic)
BioCyc:YEAST_PWY3O-123 dolichyl phosphate D-mannose biosynthesis
BioCyc:YEAST_MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS protein N-glycosylation (eukaryotic) initial steps
BioCyc:ARA_MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS protein N-glycosylation (eukaryotic, high mannose)
BioCyc:HUMAN_MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis
BioCyc:HUMAN_PWY-7979 protein O-mannosylation III (mammals, core M3)
BioCyc:META_PWY-7885 phosphatidylinositol mannoside biosynthesis
BioCyc:META_PWY-7979 protein O-mannosylation III (mammals, core M3)
BioCyc:YEAST_PWY-7921 protein O-mannosylation I (yeast)
BioCyc:MTBH37RV_PWY-7885 phosphatidylinositol mannoside biosynthesis
BioCyc:MOUSE_MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis
BioCyc:META_PWY-7921 protein O-mannosylation I (yeast)
BioCyc:META_PWY-7922 protein O-mannosylation II (mammals, core M1 and core M2)
PlantCyc:ARA_MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS protein N-glycosylation initial phase (eukaryotic)
PlantCyc:PLANT_MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS protein N-glycosylation initial phase (eukaryotic)
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-HSA-9918432 Maturation of DENV proteins
Reactome:R-HSA-9918487 Dengue Virus Genome Translation and Replication
Reactome:R-HSA-9839923 Dengue Virus Infection
Reactome:R-SPO-162699 Synthesis of dolichyl-phosphate mannose
Reactome:R-DME-162699 Synthesis of dolichyl-phosphate mannose
Reactome:R-DDI-597592 Post-translational protein modification
Reactome:R-DDI-163125 Post-translational modification: synthesis of GPI-anchored proteins
Reactome:R-DDI-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-DME-597592 Post-translational protein modification
Reactome:R-DME-163125 Post-translational modification: synthesis of GPI-anchored proteins
Reactome:R-DME-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-HSA-392499 Metabolism of proteins
Reactome:R-HSA-597592 Post-translational protein modification
Reactome:R-HSA-1643685 Disease
Reactome:R-MMU-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-SPO-446203 Asparagine N-linked glycosylation
Reactome:R-SSC-162699 Synthesis of dolichyl-phosphate mannose
Reactome:R-SSC-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-DDI-392499 Metabolism of proteins
Reactome:R-DDI-446203 Asparagine N-linked glycosylation
Reactome:R-DME-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-HSA-3781865 Diseases of glycosylation
Reactome:R-HSA-4719360 Defective DPM3 causes CDG-1o
Reactome:R-MMU-162699 Synthesis of dolichyl-phosphate mannose
Reactome:R-MMU-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-SSC-392499 Metabolism of proteins
Reactome:R-SSC-163125 Post-translational modification: synthesis of GPI-anchored proteins
Reactome:R-SSC-446203 Asparagine N-linked glycosylation
Reactome:R-DDI-162699 Synthesis of dolichyl-phosphate mannose
Reactome:R-DDI-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-DME-392499 Metabolism of proteins
Reactome:R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
Reactome:R-HSA-446203 Asparagine N-linked glycosylation
Reactome:R-HSA-5668914 Diseases of metabolism
Reactome:R-MMU-392499 Metabolism of proteins
Reactome:R-MMU-597592 Post-translational protein modification
Reactome:R-SPO-392499 Metabolism of proteins
Reactome:R-SPO-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-SSC-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-DME-446203 Asparagine N-linked glycosylation
Reactome:R-HSA-162699 Synthesis of dolichyl-phosphate mannose
Reactome:R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis
Reactome:R-HSA-4719377 Defective DPM2 causes CDG-1u
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
Reactome:R-MMU-446203 Asparagine N-linked glycosylation
Reactome:R-SPO-597592 Post-translational protein modification
Reactome:R-SPO-163125 Post-translational modification: synthesis of GPI-anchored proteins
Reactome:R-SPO-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-SSC-597592 Post-translational protein modification
WikiPathways:WP4521 Glycosylation and related congenital defects
PathBank:SMP0002400 N-Glycan Biosynthesis